socs1 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description suppressor of cytokine signaling 1|This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 8651)
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Genes

83 genes co-occuring with the biological term socs1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB5 ATP-binding cassette, sub-family B (MDR/TAP), member 5
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACKR3 atypical chemokine receptor 3
BCL2A1 BCL2-related protein A1
BCR breakpoint cluster region
CCL11 chemokine (C-C motif) ligand 11
CCL2 chemokine (C-C motif) ligand 2
CISH cytokine inducible SH2-containing protein
CLEC16A C-type lectin domain family 16, member A
CLEC4M C-type lectin domain family 4, member M
COMMD1 copper metabolism (Murr1) domain containing 1
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CXCR4 chemokine (C-X-C motif) receptor 4
CYTIP cytohesin 1 interacting protein
DDX43 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DEXI Dexi homolog (mouse)
EGR1 early growth response 1
EXOSC5 exosome component 5
FAS Fas cell surface death receptor
FGFR3 fibroblast growth factor receptor 3
FN1 fibronectin 1
GFI1 growth factor independent 1 transcription repressor
GLI1 GLI family zinc finger 1
GLI2 GLI family zinc finger 2
HDAC8 histone deacetylase 8
IFNA1 interferon, alpha 1
IFNA2 interferon, alpha 2
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFNB1 interferon, beta 1, fibroblast
IFNG interferon, gamma
IFNGR1 interferon gamma receptor 1
IFNL1 interferon, lambda 1
IFNL2 interferon, lambda 2
IGHE immunoglobulin heavy constant epsilon
IL10 interleukin 10
IL12B interleukin 12B
IL13 interleukin 13
IL18R1 interleukin 18 receptor 1
IL1B interleukin 1, beta
IL22 interleukin 22
IL27 interleukin 27
IL4 interleukin 4
IL6 interleukin 6
JAK2 Janus kinase 2
LCK LCK proto-oncogene, Src family tyrosine kinase
LIF leukemia inhibitory factor
MAPK14 mitogen-activated protein kinase 14
MIR122 microRNA 122
MIR150 microRNA 150
MIR155 microRNA 155
MIR19A microRNA 19a
MIR221 microRNA 221
MIR30D microRNA 30d
MX1 MX dynamin-like GTPase 1
NDRG2 NDRG family member 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NR0B2 nuclear receptor subfamily 0, group B, member 2
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
PDCD1 programmed cell death 1
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
SHH sonic hedgehog
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
SOCS1 suppressor of cytokine signaling 1
SOCS2 suppressor of cytokine signaling 2
SOCS3 suppressor of cytokine signaling 3
SOCS4 suppressor of cytokine signaling 4
SOCS5 suppressor of cytokine signaling 5
SOCS7 suppressor of cytokine signaling 7
SP2 Sp2 transcription factor
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT2 signal transducer and activator of transcription 2, 113kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5A signal transducer and activator of transcription 5A
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
TGFB1 transforming growth factor, beta 1
TLR2 toll-like receptor 2
TLR3 toll-like receptor 3
TNF tumor necrosis factor
TRIM8 tripartite motif containing 8
TYK2 tyrosine kinase 2