socs3 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description suppressor of cytokine signaling 3|This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 9021)
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Genes

104 genes co-occuring with the biological term socs3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACKR3 atypical chemokine receptor 3
AGRP agouti related neuropeptide
AKT1 v-akt murine thymoma viral oncogene homolog 1
BCL2 B-cell CLL/lymphoma 2
BCR breakpoint cluster region
CCL11 chemokine (C-C motif) ligand 11
CCL2 chemokine (C-C motif) ligand 2
CIITA class II, major histocompatibility complex, transactivator
CISH cytokine inducible SH2-containing protein
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CUEDC2 CUE domain containing 2
CXCR2 chemokine (C-X-C motif) receptor 2
CXCR4 chemokine (C-X-C motif) receptor 4
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DNMT1 DNA (cytosine-5-)-methyltransferase 1
EGFR epidermal growth factor receptor
EPOR erythropoietin receptor
FAM20A family with sequence similarity 20, member A
FGF2 fibroblast growth factor 2 (basic)
FGFR3 fibroblast growth factor receptor 3
FOXO3 forkhead box O3
FOXP3 forkhead box P3
GH1 growth hormone 1
HDAC8 histone deacetylase 8
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
IFNA1 interferon, alpha 1
IFNA2 interferon, alpha 2
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFNB1 interferon, beta 1, fibroblast
IFNG interferon, gamma
IFNL3 interferon, lambda 3
IL10 interleukin 10
IL10RA interleukin 10 receptor, alpha
IL11 interleukin 11
IL12A interleukin 12A
IL17A interleukin 17A
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL22 interleukin 22
IL4 interleukin 4
IL6 interleukin 6
IL6R interleukin 6 receptor
IL6ST interleukin 6 signal transducer
IRF2 interferon regulatory factor 2
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
JAK1 Janus kinase 1
JAK2 Janus kinase 2
JUN jun proto-oncogene
KDM1A lysine (K)-specific demethylase 1A
LCK LCK proto-oncogene, Src family tyrosine kinase
LEP leptin
LEPR leptin receptor
MAP1S microtubule-associated protein 1S
MAP2K6 mitogen-activated protein kinase kinase 6
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MIR122 microRNA 122
MIR19A microRNA 19a
MIR221 microRNA 221
MSTN myostatin
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MUC8 mucin 8
NCAM1 neural cell adhesion molecule 1
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NONO non-POU domain containing, octamer-binding
NPY5R neuropeptide Y receptor Y5
PCM1 pericentriolar material 1
PIAS1 protein inhibitor of activated STAT, 1
PIAS3 protein inhibitor of activated STAT, 3
PPARG peroxisome proliferator-activated receptor gamma
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRL prolactin
PTEN phosphatase and tensin homolog
PTK2 protein tyrosine kinase 2
PTK2B protein tyrosine kinase 2 beta
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3
RETN resistin
SETD7 SET domain containing (lysine methyltransferase) 7
SOCS1 suppressor of cytokine signaling 1
SOCS2 suppressor of cytokine signaling 2
SOCS3 suppressor of cytokine signaling 3
SOCS5 suppressor of cytokine signaling 5
SP3 Sp3 transcription factor
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5A signal transducer and activator of transcription 5A
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1
TFDP1 transcription factor Dp-1
TGFB1 transforming growth factor, beta 1
TLR2 toll-like receptor 2
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TNF tumor necrosis factor
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b
TP53 tumor protein p53
TPO thyroid peroxidase