sod2 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description superoxide dismutase 2, mitochondrial|This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 6648)
Similar Terms
Downloads & Tools

Genes

64 genes co-occuring with the biological term sod2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANXA2 annexin A2
AR androgen receptor
ARG1 arginase 1
ATM ATM serine/threonine kinase
ATXN3 ataxin 3
CAT catalase
CXCL8 chemokine (C-X-C motif) ligand 8
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDB2 damage-specific DNA binding protein 2, 48kDa
ERCC2 excision repair cross-complementation group 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FOXO4 forkhead box O4
GPX1 glutathione peroxidase 1
GPX3 glutathione peroxidase 3
GSTM1 glutathione S-transferase mu 1
GSTP1 glutathione S-transferase pi 1
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HOXA13 homeobox A13
IL1B interleukin 1, beta
IL6 interleukin 6
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MBP myelin basic protein
MGST1 microsomal glutathione S-transferase 1
MIR222 microRNA 222
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
MT-ATP6 ATP synthase F0 subunit 6
NAMPT nicotinamide phosphoribosyltransferase
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOS3 nitric oxide synthase 3 (endothelial cell)
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NQO1 NAD(P)H dehydrogenase, quinone 1
NQO2 NAD(P)H dehydrogenase, quinone 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
PINK1 PTEN induced putative kinase 1
PON1 paraoxonase 1
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PTEN phosphatase and tensin homolog
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
S100A8 S100 calcium binding protein A8
SIRT1 sirtuin 1
SIRT3 sirtuin 3
SOD1 superoxide dismutase 1, soluble
SOD2 superoxide dismutase 2, mitochondrial
SOD3 superoxide dismutase 3, extracellular
SP1 Sp1 transcription factor
SP3 Sp3 transcription factor
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TDRP testis development related protein
TGFB1 transforming growth factor, beta 1
TNF tumor necrosis factor
USP36 ubiquitin specific peptidase 36
VASH1 vasohibin 1
VEGFA vascular endothelial growth factor A
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3