sox2 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description SRY (sex determining region Y)-box 2|This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 6657)
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Genes

119 genes co-occuring with the biological term sox2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AMELX amelogenin, X-linked
AR androgen receptor
ASCL1 achaete-scute family bHLH transcription factor 1
ASXL1 additional sex combs like transcriptional regulator 1
BCL2L2 BCL2-like 2
BMI1 BMI1 proto-oncogene, polycomb ring finger
BMP2 bone morphogenetic protein 2
BMP4 bone morphogenetic protein 4
BRAF B-Raf proto-oncogene, serine/threonine kinase
CARM1 coactivator-associated arginine methyltransferase 1
CCND1 cyclin D1
CCNE1 cyclin E1
CD44 CD44 molecule (Indian blood group)
CDX1 caudal type homeobox 1
CDX2 caudal type homeobox 2
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTSB cathepsin B
DAZL deleted in azoospermia-like
DKK1 dickkopf WNT signaling pathway inhibitor 1
EED embryonic ectoderm development
EGFR epidermal growth factor receptor
ELF4 E74-like factor 4 (ets domain transcription factor)
ENG endoglin
ESR1 estrogen receptor 1
EWSR1 EWS RNA-binding protein 1
FGF4 fibroblast growth factor 4
FGFR1 fibroblast growth factor receptor 1
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FOXA1 forkhead box A1
FOXO1 forkhead box O1
GJA1 gap junction protein, alpha 1, 43kDa
HESX1 HESX homeobox 1
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HIST3H3 histone cluster 3, H3
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGF1R insulin-like growth factor 1 receptor
IL6 interleukin 6
ITGA6 integrin, alpha 6
JAG1 jagged 1
JUN jun proto-oncogene
KDM1A lysine (K)-specific demethylase 1A
KLF4 Kruppel-like factor 4 (gut)
LHX2 LIM homeobox 2
LHX3 LIM homeobox 3
LIN28A lin-28 homolog A (C. elegans)
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MAS1 MAS1 proto-oncogene, G protein-coupled receptor
MET MET proto-oncogene, receptor tyrosine kinase
MIR126 microRNA 126
MIR140 microRNA 140
MIR142 microRNA 142
MIR145 microRNA 145
MIR200C microRNA 200c
MIR21 microRNA 21
MIR378A microRNA 378a
MIR638 microRNA 638
MIRLET7A1 microRNA let-7a-1
MITF microphthalmia-associated transcription factor
MMP2 matrix metallopeptidase 2
MMP3 matrix metallopeptidase 3
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MYC v-myc avian myelocytomatosis viral oncogene homolog
NANOG Nanog homeobox
NES nestin
NOTCH1 notch 1
NTRK3 neurotrophic tyrosine kinase, receptor, type 3
OTX2 orthodenticle homeobox 2
PARP1 poly (ADP-ribose) polymerase 1
PAX6 paired box 6
PDPN podoplanin
PLAUR plasminogen activator, urokinase receptor
PLK1 polo-like kinase 1
POU2F1 POU class 2 homeobox 1
POU5F1 POU class 5 homeobox 1
PRKCI protein kinase C, iota
PROM1 prominin 1
PTN pleiotrophin
RCOR2 REST corepressor 2
RHOA ras homolog family member A
RMST rhabdomyosarcoma 2 associated transcript (non-protein coding)
S100B S100 calcium binding protein B
SALL4 spalt-like transcription factor 4
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SETD7 SET domain containing (lysine methyltransferase) 7
SHH sonic hedgehog
SLC22A1 solute carrier family 22 (organic cation transporter), member 1
SLC22A2 solute carrier family 22 (organic cation transporter), member 2
SMAD1 SMAD family member 1
SMAD2 SMAD family member 2
SMAD3 SMAD family member 3
SMAD5 SMAD family member 5
SNAI2 snail family zinc finger 2
SOX1 SRY (sex determining region Y)-box 1
SOX11 SRY (sex determining region Y)-box 11
SOX17 SRY (sex determining region Y)-box 17
SOX2 SRY (sex determining region Y)-box 2
SOX21 SRY (sex determining region Y)-box 21
SOX3 SRY (sex determining region Y)-box 3
SOX4 SRY (sex determining region Y)-box 4
SOX8 SRY (sex determining region Y)-box 8
SOX9 SRY (sex determining region Y)-box 9
SRRD SRR1 domain containing
SRY sex determining region Y
SS18 synovial sarcoma translocation, chromosome 18
SSX1 synovial sarcoma, X breakpoint 1
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TERT telomerase reverse transcriptase
TP53 tumor protein p53
TP63 tumor protein p63
TWIST1 twist family bHLH transcription factor 1
VIM vimentin
VSX2 visual system homeobox 2
YBX1 Y box binding protein 1
ZNF274 zinc finger protein 274