sox4_16636670_acc3_lof_human_gpl96_gds2193 Gene Set

Dataset GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations
Category transcriptomics
Type transcription factor perturbation
Description transcription factor perturbation identified as [TF gene symbol]_[publication PMID]_[cell or tissue]_[perturbation]_[organism]_[GEO platform]_[GEO accession] (Gene Expression Omnibus)
External Link http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GDS2193
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Genes

302 genes differentially expressed following the sox4_16636670_acc3_lof_human_gpl96_gds2193 transcription factor perturbation from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.

increased expression

Symbol Name Standardized Value
PLIN2 perilipin 2 0.212046
SMNDC1 survival motor neuron domain containing 1 0.210828
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.210338
BANP BTG3 associated nuclear protein 0.209869
CLN5 ceroid-lipofuscinosis, neuronal 5 0.208674
ZBTB17 zinc finger and BTB domain containing 17 0.208518
ELF4 E74-like factor 4 (ets domain transcription factor) 0.208262
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2) 0.205708
NSFL1C NSFL1 (p97) cofactor (p47) 0.202232
HMHA1 histocompatibility (minor) HA-1 0.201941
GSTT1 glutathione S-transferase theta 1 0.198999
TNIP2 TNFAIP3 interacting protein 2 0.197631
ING2 inhibitor of growth family, member 2 0.197015
PDZK1 PDZ domain containing 1 0.195914
ABI3BP ABI family, member 3 (NESH) binding protein 0.194903
PPP4R1 protein phosphatase 4, regulatory subunit 1 0.192308
AMPD3 adenosine monophosphate deaminase 3 0.191242
KCMF1 potassium channel modulatory factor 1 0.186084
JUND jun D proto-oncogene 0.185557
ZNF79 zinc finger protein 79 0.184313
VCPKMT valosin containing protein lysine (K) methyltransferase 0.177317
PAPOLA poly(A) polymerase alpha 0.177178
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 0.17256
HRH1 histamine receptor H1 0.171986
STC2 stanniocalcin 2 0.170809
FAM47E family with sequence similarity 47, member E 0.168445
GTPBP2 GTP binding protein 2 0.167759
FLJ11292 0.164545
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.157714
RIOK3 RIO kinase 3 0.157462
CCDC130 coiled-coil domain containing 130 0.157399
SETD4 SET domain containing 4 0.1526
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 0.150966
CCNT2 cyclin T2 0.148094
LONRF3 LON peptidase N-terminal domain and ring finger 3 0.146916
ASXL1 additional sex combs like transcriptional regulator 1 0.145446
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.141394
APOL2 apolipoprotein L, 2 0.140118
NAMPT nicotinamide phosphoribosyltransferase 0.137109
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.136276
MARCH5 membrane-associated ring finger (C3HC4) 5 0.135271
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.134956
WDR47 WD repeat domain 47 0.134925
TRIM8 tripartite motif containing 8 0.13211
NCKIPSD NCK interacting protein with SH3 domain 0.130305
GRB10 growth factor receptor-bound protein 10 0.12797
RNF103 ring finger protein 103 0.12797
RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae) 0.126138
AK4 adenylate kinase 4 0.123313
CDK13 cyclin-dependent kinase 13 0.122485
KDM4B lysine (K)-specific demethylase 4B 0.121613
OAZ3 ornithine decarboxylase antizyme 3 0.12155
ALOX5 arachidonate 5-lipoxygenase 0.120788
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 0.116058
NOL7 nucleolar protein 7, 27kDa 0.114109
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F 0.112845
UBE2G1 ubiquitin-conjugating enzyme E2G 1 0.110875
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.107336
CASP5 caspase 5, apoptosis-related cysteine peptidase 0.106862
FAM131A family with sequence similarity 131, member A 0.104821
TXNL1 thioredoxin-like 1 0.104379
SIK3 SIK family kinase 3 0.102693
VEGFA vascular endothelial growth factor A 0.101951
ZEB1 zinc finger E-box binding homeobox 1 0.09988
BTN2A1 butyrophilin, subfamily 2, member A1 0.099458
SMAP1 small ArfGAP 1 0.098284
TXNDC9 thioredoxin domain containing 9 0.097128
TMBIM1 transmembrane BAX inhibitor motif containing 1 0.094538
IMP3 IMP3, U3 small nucleolar ribonucleoprotein 0.091414
ANKLE2 ankyrin repeat and LEM domain containing 2 0.089446
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.088797
IL1B interleukin 1, beta 0.084834
TENM4 teneurin transmembrane protein 4 0.083959
INSIG2 insulin induced gene 2 0.077124
BRPF1 bromodomain and PHD finger containing, 1 0.075323
CEP72 centrosomal protein 72kDa 0.074625
CFLAR CASP8 and FADD-like apoptosis regulator 0.073872
CXCR4 chemokine (C-X-C motif) receptor 4 0.072681
SYT13 synaptotagmin XIII 0.072553
OSER1 oxidative stress responsive serine-rich 1 0.070903
ZSCAN16 zinc finger and SCAN domain containing 16 0.069525
AKTIP AKT interacting protein 0.067986
CCNG2 cyclin G2 0.063356
SOD2 superoxide dismutase 2, mitochondrial 0.061229
ZNF444 zinc finger protein 444 0.056722
ZNF394 zinc finger protein 394 0.053074
RASSF1 Ras association (RalGDS/AF-6) domain family member 1 0.052309
RPL26 ribosomal protein L26 0.052132
BBC3 BCL2 binding component 3 0.051078
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.045002
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.043604
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme 0.042893
PELI1 pellino E3 ubiquitin protein ligase 1 0.041506
SMPX small muscle protein, X-linked 0.041365
ZNF443 zinc finger protein 443 0.04066
UBN1 ubinuclein 1 0.039844
SP2 Sp2 transcription factor 0.038781
ZFP36L2 ZFP36 ring finger protein-like 2 0.037721
SCG5 secretogranin V 0.037582
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.036554
KRTAP2-4 keratin associated protein 2-4 0.036082
BCL10 B-cell CLL/lymphoma 10 0.035146
SNW1 SNW domain containing 1 0.03227
CLCN6 chloride channel, voltage-sensitive 6 0.030397
TTYH1 tweety family member 1 0.029697
COMT catechol-O-methyltransferase 0.0279
PFDN4 prefoldin subunit 4 0.027151
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa 0.022486
FBXO17 F-box protein 17 0.020485
BCOR BCL6 corepressor 0.019814
HEMK1 HemK methyltransferase family member 1 0.016438
MYD88 myeloid differentiation primary response 88 0.014042
KDM3A lysine (K)-specific demethylase 3A 0.013816
FEM1B fem-1 homolog b (C. elegans) 0.009821
CRBN cereblon 0.00943
TMEM158 transmembrane protein 158 (gene/pseudogene) 0.007648
UBC ubiquitin C 0.007284
TOM1L2 target of myb1-like 2 (chicken) 0.006126
ZFP36L1 ZFP36 ring finger protein-like 1 0.005838
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.00579
FGD6 FYVE, RhoGEF and PH domain containing 6 0.005188
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.004375
PGS1 phosphatidylglycerophosphate synthase 1 0.004352
TTC4 tetratricopeptide repeat domain 4 0.003828
INTS6 integrator complex subunit 6 0.002146
RIT1 Ras-like without CAAX 1 9.04E-4

decreased expression

Symbol Name Standardized Value
FAHD2A fumarylacetoacetate hydrolase domain containing 2A -1.22737
COMMD4 COMM domain containing 4 -1.22066
CALD1 caldesmon 1 -1.21074
MCCC2 methylcrotonoyl-CoA carboxylase 2 (beta) -1.21002
TRIM29 tripartite motif containing 29 -1.2097
MIR1244-2 microRNA 1244-2 -1.19534
PDHA1 pyruvate dehydrogenase (lipoamide) alpha 1 -1.18125
KIF20A kinesin family member 20A -1.1788
KATNB1 katanin p80 (WD repeat containing) subunit B 1 -1.1748
TUFM Tu translation elongation factor, mitochondrial -1.17448
DMPK dystrophia myotonica-protein kinase -1.15495
ZC3H4 zinc finger CCCH-type containing 4 -1.14372
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 -1.13069
ACOT7 acyl-CoA thioesterase 7 -1.12809
DIMT1 DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae) -1.11837
CLN3 ceroid-lipofuscinosis, neuronal 3 -1.11414
LOC100506699 uncharacterized LOC100506699 -1.11282
NCAPD2 non-SMC condensin I complex, subunit D2 -1.10474
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0 -1.0722
HMOX2 heme oxygenase 2 -1.06494
HSPA8 heat shock 70kDa protein 8 -1.0571
TDP1 tyrosyl-DNA phosphodiesterase 1 -1.05557
DGCR8 DGCR8 microprocessor complex subunit -1.04754
GLUL glutamate-ammonia ligase -1.01173
PCDH17 protocadherin 17 -0.997958
TLR4 toll-like receptor 4 -0.992238
FLOT2 flotillin 2 -0.98352
LIMK1 LIM domain kinase 1 -0.938138
TBCCD1 TBCC domain containing 1 -0.931294
ALG3 ALG3, alpha-1,3- mannosyltransferase -0.926061
HFE hemochromatosis -0.920674
CCNB1 cyclin B1 -0.906241
PTBP1 polypyrimidine tract binding protein 1 -0.893023
MTCH2 mitochondrial carrier 2 -0.884411
TUBB tubulin, beta class I -0.883185
PEG10 paternally expressed 10 -0.882573
PARVB parvin, beta -0.873495
GPD1L glycerol-3-phosphate dehydrogenase 1-like -0.856904
ATP5D ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit -0.852085
CDK14 cyclin-dependent kinase 14 -0.84555
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 -0.842999
TMX2 thioredoxin-related transmembrane protein 2 -0.835893
PROSC proline synthetase co-transcribed homolog (bacterial) -0.832837
UBE2S ubiquitin-conjugating enzyme E2S -0.830497
TNNI2 troponin I type 2 (skeletal, fast) -0.8235
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1 -0.8235
SIGMAR1 sigma non-opioid intracellular receptor 1 -0.823051
BIN1 bridging integrator 1 -0.806914
TRAF3IP3 TRAF3 interacting protein 3 -0.796178
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B -0.790468
SRI sorcin -0.789205
TUBB3 tubulin, beta 3 class III -0.785806
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8 -0.770312
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase -0.76026
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 -0.760128
ANAPC5 anaphase promoting complex subunit 5 -0.754185
NACAD NAC alpha domain containing -0.737401
IFITM3 interferon induced transmembrane protein 3 -0.733987
GM2A GM2 ganglioside activator -0.732703
H2AFY H2A histone family, member Y -0.732083
SDHAF3 succinate dehydrogenase complex assembly factor 3 -0.724311
PRPF31 pre-mRNA processing factor 31 -0.72104
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2 -0.709696
TMEM97 transmembrane protein 97 -0.705648
HPSE heparanase -0.702022
GUCY2D guanylate cyclase 2D, membrane (retina-specific) -0.700643
MTMR7 myotubularin related protein 7 -0.694232
MARC1 mitochondrial amidoxime reducing component 1 -0.691159
POLR2F polymerase (RNA) II (DNA directed) polypeptide F -0.687963
TTPA tocopherol (alpha) transfer protein -0.68726
VSTM4 V-set and transmembrane domain containing 4 -0.681756
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -0.636843
SPCS3 signal peptidase complex subunit 3 homolog (S. cerevisiae) -0.623137
CELP carboxyl ester lipase pseudogene -0.622258
POLD1 polymerase (DNA directed), delta 1, catalytic subunit -0.621246
CCDC102B coiled-coil domain containing 102B -0.62057
EEA1 early endosome antigen 1 -0.619428
GRK6 G protein-coupled receptor kinase 6 -0.616164
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha -0.608305
HACD3 3-hydroxyacyl-CoA dehydratase 3 -0.606437
CENPI centromere protein I -0.604959
MSTO2P misato family member 2, pseudogene -0.603553
BIRC5 baculoviral IAP repeat containing 5 -0.601149
TMA7 translation machinery associated 7 homolog (S. cerevisiae) -0.592004
PTN pleiotrophin -0.572259
PTGES prostaglandin E synthase -0.565106
DLAT dihydrolipoamide S-acetyltransferase -0.564494
HNRNPL heterogeneous nuclear ribonucleoprotein L -0.562345
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8 -0.560868
RRP7A ribosomal RNA processing 7 homolog A (S. cerevisiae) -0.549592
ADAM19 ADAM metallopeptidase domain 19 -0.549175
TMEM144 transmembrane protein 144 -0.541473
TMEM14A transmembrane protein 14A -0.531448
MCM7 minichromosome maintenance complex component 7 -0.531255
NDUFS7 NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) -0.524924
PTCH1 patched 1 -0.522504
CTSC cathepsin C -0.513742
FABP7 fatty acid binding protein 7, brain -0.508319
NPRL3 nitrogen permease regulator-like 3 (S. cerevisiae) -0.504176
BTN3A3 butyrophilin, subfamily 3, member A3 -0.503212
GCDH glutaryl-CoA dehydrogenase -0.502336
SNRPF small nuclear ribonucleoprotein polypeptide F -0.49723
COMP cartilage oligomeric matrix protein -0.495568
ACTBP9 actin, beta pseudogene 9 -0.493972
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -0.490269
SYMPK symplekin -0.48612
MID1 midline 1 -0.483007
HRSP12 heat-responsive protein 12 -0.480909
PTPRJ protein tyrosine phosphatase, receptor type, J -0.473728
ABHD6 abhydrolase domain containing 6 -0.470698
DKFZP564C152 DKFZP564C152 protein -0.463724
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein -0.462889
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -0.45894
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -0.458512
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) -0.455484
PRDX6 peroxiredoxin 6 -0.454772
QKI QKI, KH domain containing, RNA binding -0.454418
TNMD tenomodulin -0.453384
UBAP2L ubiquitin associated protein 2-like -0.450905
MAP2K6 mitogen-activated protein kinase kinase 6 -0.450734
DACH1 dachshund family transcription factor 1 -0.445933
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast) -0.444835
ADSL adenylosuccinate lyase -0.443425
MRPS12 mitochondrial ribosomal protein S12 -0.440662
FGFR4 fibroblast growth factor receptor 4 -0.440487
GAA glucosidase, alpha; acid -0.439261
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A -0.433668
HTATSF1 HIV-1 Tat specific factor 1 -0.431847
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2 -0.431221
CEP55 centrosomal protein 55kDa -0.429895
AGO2 argonaute RISC catalytic component 2 -0.065668
CAMTA2 calmodulin binding transcription activator 2 -0.062029
BNIP1 BCL2/adenovirus E1B 19kDa interacting protein 1 -0.061073
NCK1 NCK adaptor protein 1 -0.060926
NLRP3 NLR family, pyrin domain containing 3 -0.059616
RAE1 ribonucleic acid export 1 -0.059447
ZNF212 zinc finger protein 212 -0.059242
HMP19 HMP19 protein -0.054941
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 -0.053122
ZFAND5 zinc finger, AN1-type domain 5 -0.050985
PKD1 polycystic kidney disease 1 (autosomal dominant) -0.050448
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D -0.04908
NEK1 NIMA-related kinase 1 -0.048194
DUSP4 dual specificity phosphatase 4 -0.047652
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 -0.0465
ACBD3 acyl-CoA binding domain containing 3 -0.044994
ZNF668 zinc finger protein 668 -0.041068
LONP1 lon peptidase 1, mitochondrial -0.040506
EIF5 eukaryotic translation initiation factor 5 -0.036814
MAP3K9 mitogen-activated protein kinase kinase kinase 9 -0.036538
SEPT4 septin 4 -0.036368
IGFBP7 insulin-like growth factor binding protein 7 -0.034122
MAP3K4 mitogen-activated protein kinase kinase kinase 4 -0.033392
PARP8 poly (ADP-ribose) polymerase family, member 8 -0.032506
PPARD peroxisome proliferator-activated receptor delta -0.032116
IST1 increased sodium tolerance 1 homolog (yeast) -0.03038
FOXJ3 forkhead box J3 -0.029374
C1ORF116 chromosome 1 open reading frame 116 -0.026057
LIF leukemia inhibitory factor -0.026013
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.025171
U2SURP U2 snRNP-associated SURP domain containing -0.022837
COA4 cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae) -0.020151
GPATCH8 G patch domain containing 8 -0.019408
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 -0.018825
SWAP70 SWAP switching B-cell complex 70kDa subunit -0.018757
ANGPT2 angiopoietin 2 -0.017514
PEA15 phosphoprotein enriched in astrocytes 15 -0.016971
IRF9 interferon regulatory factor 9 -0.016948
ATAD2B ATPase family, AAA domain containing 2B -0.016
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G -0.015841
LRP12 low density lipoprotein receptor-related protein 12 -0.012515
TRO trophinin -0.012423
MPPED2 metallophosphoesterase domain containing 2 -0.004788
OXR1 oxidation resistance 1 -0.002867
CTBP2 C-terminal binding protein 2 -0.001983
TMUB2 transmembrane and ubiquitin-like domain containing 2 -0.001518
Funding