sp3_17923686_e12dot5_heart_lof_mouse_gpl1261_gds3058 Gene Set

Dataset GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations
Category transcriptomics
Type transcription factor perturbation
Description transcription factor perturbation identified as [TF gene symbol]_[publication PMID]_[cell or tissue]_[perturbation]_[organism]_[GEO platform]_[GEO accession] (Gene Expression Omnibus)
External Link http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GDS3058
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Genes

577 genes differentially expressed following the sp3_17923686_e12dot5_heart_lof_mouse_gpl1261_gds3058 transcription factor perturbation from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.

increased expression

Symbol Name Standardized Value
RBM45 RNA binding motif protein 45 0.21355
TEX33 testis expressed 33 0.213494
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) 0.212987
CD47 CD47 molecule 0.212776
SLC9A9 solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9 0.212524
DMC1 DNA meiotic recombinase 1 0.212425
SHE Src homology 2 domain containing E 0.21171
PCP2 Purkinje cell protein 2 0.207709
SYNC syncoilin, intermediate filament protein 0.207242
NEIL1 nei endonuclease VIII-like 1 (E. coli) 0.207213
ABCC12 ATP-binding cassette, sub-family C (CFTR/MRP), member 12 0.205909
OGFOD2 2-oxoglutarate and iron-dependent oxygenase domain containing 2 0.205463
PARG poly (ADP-ribose) glycohydrolase 0.205089
DBP D site of albumin promoter (albumin D-box) binding protein 0.204313
CWH43 cell wall biogenesis 43 C-terminal homolog (S. cerevisiae) 0.204285
C20ORF141 chromosome 20 open reading frame 141 0.202538
RNF2 ring finger protein 2 0.201723
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 0.200953
TMEM218 transmembrane protein 218 0.198763
COL5A2 collagen, type V, alpha 2 0.196869
POFUT2 protein O-fucosyltransferase 2 0.196839
ZC3H12C zinc finger CCCH-type containing 12C 0.196546
HSPB3 heat shock 27kDa protein 3 0.195631
MAP2K7 mitogen-activated protein kinase kinase 7 0.19333
B4GALNT4 beta-1,4-N-acetyl-galactosaminyl transferase 4 0.193079
KANK3 KN motif and ankyrin repeat domains 3 0.192458
AP5B1 adaptor-related protein complex 5, beta 1 subunit 0.191152
FKBP11 FK506 binding protein 11, 19 kDa 0.190553
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase 0.189133
R3HCC1L R3H domain and coiled-coil containing 1-like 0.188835
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 0.188442
HDAC4 histone deacetylase 4 0.186959
MAGEB3 melanoma antigen family B3 0.184526
ZMIZ1 zinc finger, MIZ-type containing 1 0.180181
SYCE2 synaptonemal complex central element protein 2 0.178205
CLDN2 claudin 2 0.177732
NID2 nidogen 2 (osteonidogen) 0.177286
ADGRL3 adhesion G protein-coupled receptor L3 0.175387
PNLIPRP2 pancreatic lipase-related protein 2 0.173476
GID4 GID complex subunit 4 0.173088
PEG3 paternally expressed 3 0.172653
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 0.171211
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 0.170561
COMMD3 COMM domain containing 3 0.168382
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.159973
IFT81 intraflagellar transport 81 0.159566
VSTM2L V-set and transmembrane domain containing 2 like 0.156047
BUB3 BUB3 mitotic checkpoint protein 0.154698
NEK1 NIMA-related kinase 1 0.147591
HEXA hexosaminidase A (alpha polypeptide) 0.144059
MYADML2 myeloid-associated differentiation marker-like 2 0.138876
TMIGD1 transmembrane and immunoglobulin domain containing 1 0.137787
ARSK arylsulfatase family, member K 0.137503
ACTRT1 actin-related protein T1 0.137156
PAQR8 progestin and adipoQ receptor family member VIII 0.136527
FGFRL1 fibroblast growth factor receptor-like 1 0.133397
RFX4 regulatory factor X, 4 (influences HLA class II expression) 0.132847
BMI1 BMI1 proto-oncogene, polycomb ring finger 0.131531
SKOR1 SKI family transcriptional corepressor 1 0.130871
CCL25 chemokine (C-C motif) ligand 25 0.130022
SLAMF1 signaling lymphocytic activation molecule family member 1 0.129818
EPC2 enhancer of polycomb homolog 2 (Drosophila) 0.123797
TIGD5 tigger transposable element derived 5 0.122969
ZNF442 zinc finger protein 442 0.116336
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta) 0.114587
CLIP1 CAP-GLY domain containing linker protein 1 0.113538
ZSWIM6 zinc finger, SWIM-type containing 6 0.106878
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.105597
KIAA0825 KIAA0825 0.102602
EID3 EP300 interacting inhibitor of differentiation 3 0.102193
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase 0.101255
SLC13A1 solute carrier family 13 (sodium/sulfate symporter), member 1 0.100484
PVT1 Pvt1 oncogene (non-protein coding) 0.098254
DVL2 dishevelled segment polarity protein 2 0.098119
ENDOU endonuclease, polyU-specific 0.097623
MAST4 microtubule associated serine/threonine kinase family member 4 0.096767
AMER2 APC membrane recruitment protein 2 0.095165
ACAD10 acyl-CoA dehydrogenase family, member 10 0.094911
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1 0.090407
CPD carboxypeptidase D 0.09017
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 0.082228
APLN apelin 0.081518
SRR serine racemase 0.081387
ZNF628 zinc finger protein 628 0.079033
SPRED1 sprouty-related, EVH1 domain containing 1 0.076079
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 0.07585
RHOH ras homolog family member H 0.074938
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3 0.073531
MID2 midline 2 0.07227
SATB1 SATB homeobox 1 0.071805
CYS1 cystin 1 0.069497
PLXNA3 plexin A3 0.069469
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 0.069217
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.067554
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.066315
SEMA5B sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B 0.061311
FAM65B family with sequence similarity 65, member B 0.061078
XPOT exportin, tRNA 0.059715
SFI1 Sfi1 homolog, spindle assembly associated (yeast) 0.058518
GNPDA2 glucosamine-6-phosphate deaminase 2 0.058072
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 0.056183
SSR4 signal sequence receptor, delta 0.054049
SLC39A6 solute carrier family 39 (zinc transporter), member 6 0.048342
RPTOR regulatory associated protein of MTOR, complex 1 0.04814
PHIP pleckstrin homology domain interacting protein 0.046899
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.046611
ZBTB26 zinc finger and BTB domain containing 26 0.045719
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.045403
R3HDM4 R3H domain containing 4 0.039957
ZBTB20 zinc finger and BTB domain containing 20 0.039704
ST8SIA2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 0.037999
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 0.035862
ARMCX5 armadillo repeat containing, X-linked 5 0.035228
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 0.034622
PLCB4 phospholipase C, beta 4 0.031292
MIOS missing oocyte, meiosis regulator, homolog (Drosophila) 0.031238
DCAF5 DDB1 and CUL4 associated factor 5 0.030261
LZTFL1 leucine zipper transcription factor-like 1 0.029051
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 0.029024
DTNA dystrobrevin, alpha 0.02873
GNAQ guanine nucleotide binding protein (G protein), q polypeptide 0.028327
APOOL apolipoprotein O-like 0.0254
SEBOX SEBOX homeobox 0.025109
EID2 EP300 interacting inhibitor of differentiation 2 0.025003
DDO D-aspartate oxidase 0.023949
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta 0.023923
SEPT11 septin 11 0.02387
NCAM1 neural cell adhesion molecule 1 0.021624
NUDT17 nudix (nucleoside diphosphate linked moiety X)-type motif 17 0.021571
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.021233
CAAP1 caspase activity and apoptosis inhibitor 1 0.021129
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa 0.020742
LIMS2 LIM and senescent cell antigen-like domains 2 0.020535
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.016766
SOCS7 suppressor of cytokine signaling 7 0.013563
HOXD8 homeobox D8 0.012887
SH3BGRL2 SH3 domain binding glutamate-rich protein like 2 0.012043
MAEA macrophage erythroblast attacher 0.011794
FGF12 fibroblast growth factor 12 0.011745
LPPR5 lipid phosphate phosphatase-related protein type 5 0.011051
DBNDD2 dysbindin (dystrobrevin binding protein 1) domain containing 2 0.008718
CXCR6 chemokine (C-X-C motif) receptor 6 0.008645
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 0.00716
UBAC2 UBA domain containing 2 0.006196
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.001439
ZNF605 zinc finger protein 605 0.001368

decreased expression

Symbol Name Standardized Value
ZDHHC2 zinc finger, DHHC-type containing 2 -1.20417
GTF3C1 general transcription factor IIIC, polypeptide 1, alpha 220kDa -1.19741
PARP16 poly (ADP-ribose) polymerase family, member 16 -1.19717
IQGAP1 IQ motif containing GTPase activating protein 1 -1.19566
C10ORF120 chromosome 10 open reading frame 120 -1.19265
KRT222 keratin 222, type II -1.19163
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -1.19131
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase -1.18943
PAQR7 progestin and adipoQ receptor family member VII -1.18786
NT5C3B 5'-nucleotidase, cytosolic IIIB -1.18646
CACNG5 calcium channel, voltage-dependent, gamma subunit 5 -1.18498
CTSZ cathepsin Z -1.18188
UPB1 ureidopropionase, beta -1.1788
TPD52 tumor protein D52 -1.17534
EBPL emopamil binding protein-like -1.17324
ATP6V1F ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F -1.17052
C2CD5 C2 calcium-dependent domain containing 5 -1.16937
NINJ1 ninjurin 1 -1.16767
NLN neurolysin (metallopeptidase M3 family) -1.16246
PSMD5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 -1.16145
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma -1.15703
PDK1 pyruvate dehydrogenase kinase, isozyme 1 -1.15227
PPAP2C phosphatidic acid phosphatase type 2C -1.15113
TK1 thymidine kinase 1, soluble -1.14561
CCDC77 coiled-coil domain containing 77 -1.14531
SLC30A6 solute carrier family 30 (zinc transporter), member 6 -1.13997
BPHL biphenyl hydrolase-like (serine hydrolase) -1.13928
CLCC1 chloride channel CLIC-like 1 -1.13761
TM2D2 TM2 domain containing 2 -1.13565
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8 -1.13234
CMBL carboxymethylenebutenolidase homolog (Pseudomonas) -1.13197
OLA1 Obg-like ATPase 1 -1.13167
NEK7 NIMA-related kinase 7 -1.12742
CPNE3 copine III -1.12676
IL17RC interleukin 17 receptor C -1.12527
ZNF287 zinc finger protein 287 -1.12466
ITGA6 integrin, alpha 6 -1.12218
SMIM7 small integral membrane protein 7 -1.12135
AES amino-terminal enhancer of split -1.12135
SH3BGRL SH3 domain binding glutamate-rich protein like -1.11238
STK26 serine/threonine protein kinase 26 -1.10996
GDF15 growth differentiation factor 15 -1.10901
RABEPK Rab9 effector protein with kelch motifs -1.10548
KPNA3 karyopherin alpha 3 (importin alpha 4) -1.10333
MOGAT2 monoacylglycerol O-acyltransferase 2 -1.10106
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -1.09545
TUBB4B tubulin, beta 4B class IVb -1.08976
NRBP1 nuclear receptor binding protein 1 -1.08707
PTGR1 prostaglandin reductase 1 -1.08678
SPRYD3 SPRY domain containing 3 -1.08345
GFAP glial fibrillary acidic protein -1.08201
GIPC2 GIPC PDZ domain containing family, member 2 -1.08072
IFI30 interferon, gamma-inducible protein 30 -1.07715
MCUR1 mitochondrial calcium uniporter regulator 1 -1.07326
ANXA8 annexin A8 -1.07063
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 -1.0636
DNTTIP1 deoxynucleotidyltransferase, terminal, interacting protein 1 -1.06142
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein -1.0587
CSTB cystatin B (stefin B) -1.05821
C19ORF12 chromosome 19 open reading frame 12 -1.05221
GRM2 glutamate receptor, metabotropic 2 -1.04949
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4 -1.04844
RNH1 ribonuclease/angiogenin inhibitor 1 -1.04796
DMRT3 doublesex and mab-3 related transcription factor 3 -1.04595
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -1.0445
ZC3H7B zinc finger CCCH-type containing 7B -1.04203
CMTM7 CKLF-like MARVEL transmembrane domain containing 7 -1.04162
ECHS1 enoyl CoA hydratase, short chain, 1, mitochondrial -1.04026
DHRS7 dehydrogenase/reductase (SDR family) member 7 -1.03788
SSSCA1 Sjogren syndrome/scleroderma autoantigen 1 -1.03068
TTC39A tetratricopeptide repeat domain 39A -1.02823
EIF4A1 eukaryotic translation initiation factor 4A1 -1.02386
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -1.02132
SP3 Sp3 transcription factor -1.01821
STAG1 stromal antigen 1 -1.0166
CDO1 cysteine dioxygenase type 1 -1.0166
ACO1 aconitase 1, soluble -1.00626
TOP1MT topoisomerase (DNA) I, mitochondrial -1.0021
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) -0.999203
PRPS2 phosphoribosyl pyrophosphate synthetase 2 -0.997043
ARSB arylsulfatase B -0.993596
ISM1 isthmin 1, angiogenesis inhibitor -0.990756
ANLN anillin, actin binding protein -0.98552
DNAI2 dynein, axonemal, intermediate chain 2 -0.981723
ADA adenosine deaminase -0.981531
GCAT glycine C-acetyltransferase -0.978785
ACTL9 actin-like 9 -0.973094
RC3H1 ring finger and CCCH-type domains 1 -0.970994
RASAL1 RAS protein activator like 1 (GAP1 like) -0.969473
ILVBL ilvB (bacterial acetolactate synthase)-like -0.968083
RBP1 retinol binding protein 1, cellular -0.962569
MAOA monoamine oxidase A -0.960892
NADK NAD kinase -0.958356
FAM114A1 family with sequence similarity 114, member A1 -0.955062
SLC35F5 solute carrier family 35, member F5 -0.950984
NIPSNAP1 nipsnap homolog 1 (C. elegans) -0.947492
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7 -0.946578
WDR37 WD repeat domain 37 -0.941113
GOLM1 golgi membrane protein 1 -0.940991
TMEM205 transmembrane protein 205 -0.936447
USP46 ubiquitin specific peptidase 46 -0.932129
SAA4 serum amyloid A4, constitutive -0.927912
CBR3 carbonyl reductase 3 -0.926359
ANXA7 annexin A7 -0.923507
ZFR zinc finger RNA binding protein -0.923507
ANXA4 annexin A4 -0.913087
C1QB complement component 1, q subcomponent, B chain -0.91297
SEPP1 selenoprotein P, plasma, 1 -0.910638
MERTK MER proto-oncogene, tyrosine kinase -0.906702
NXF3 nuclear RNA export factor 3 -0.903544
KRT8 keratin 8, type II -0.903201
ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain -0.901945
UTP6 UTP6, small subunit (SSU) processome component, homolog (yeast) -0.901831
TMEM57 transmembrane protein 57 -0.901831
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit -0.900693
GSTM5 glutathione S-transferase mu 5 -0.898416
CAPN7 calpain 7 -0.889484
ADGRV1 adhesion G protein-coupled receptor V1 -0.889148
HADH hydroxyacyl-CoA dehydrogenase -0.886806
M6PR mannose-6-phosphate receptor (cation dependent) -0.885361
PLP2 proteolipid protein 2 (colonic epithelium-enriched) -0.879747
SLC30A10 solute carrier family 30, member 10 -0.87936
MVD mevalonate (diphospho) decarboxylase -0.876117
TCAIM T cell activation inhibitor, mitochondrial -0.870826
GRAP2 GRB2-related adaptor protein 2 -0.868703
ARHGEF39 Rho guanine nucleotide exchange factor (GEF) 39 -0.868703
CKLF chemokine-like factor -0.862556
SH3TC2 SH3 domain and tetratricopeptide repeats 2 -0.862556
NMRAL1 NmrA-like family domain containing 1 -0.862556
PYCRL pyrroline-5-carboxylate reductase-like -0.862289
DSCR3 Down syndrome critical region 3 -0.862182
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae) -0.861487
S100A10 S100 calcium binding protein A10 -0.85388
FUOM fucose mutarotase -0.852243
SIN3B SIN3 transcription regulator family member B -0.852033
PITPNM3 PITPNM family member 3 -0.845133
ECH1 enoyl CoA hydratase 1, peroxisomal -0.836302
FAM109B family with sequence similarity 109, member B -0.833041
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.82395
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor -0.820164
AGPAT6 1-acylglycerol-3-phosphate O-acyltransferase 6 -0.818623
MMD2 monocyte to macrophage differentiation-associated 2 -0.815015
FAM45A family with sequence similarity 45, member A -0.811291
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase -0.786177
DDX55 DEAD (Asp-Glu-Ala-Asp) box polypeptide 55 -0.785063
PQLC3 PQ loop repeat containing 3 -0.783118
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 -0.782287
DNPEP aspartyl aminopeptidase -0.775875
LGALS2 lectin, galactoside-binding, soluble, 2 -0.774967
JKAMP JNK1/MAPK8-associated membrane protein -0.764326
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7 -0.759117
RGS7BP regulator of G-protein signaling 7 binding protein -0.758898
FADS1 fatty acid desaturase 1 -0.757934
KCNQ2 potassium channel, voltage gated KQT-like subfamily Q, member 2 -0.755925
NCEH1 neutral cholesterol ester hydrolase 1 -0.753362
STARD5 StAR-related lipid transfer (START) domain containing 5 -0.752021
MYL12B myosin, light chain 12B, regulatory -0.751373
EPS15 epidermal growth factor receptor pathway substrate 15 -0.747977
FKBP9 FK506 binding protein 9, 63 kDa -0.746395
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 -0.745798
NUPL1 nucleoporin like 1 -0.74533
SAFB scaffold attachment factor B -0.739034
BCL2L2 BCL2-like 2 -0.737025
MARVELD1 MARVEL domain containing 1 -0.734277
KHK ketohexokinase (fructokinase) -0.733987
LONP2 lon peptidase 2, peroxisomal -0.732827
GM2A GM2 ganglioside activator -0.729039
GPX7 glutathione peroxidase 7 -0.723825
PYGB phosphorylase, glycogen; brain -0.723379
SPERT spermatid associated -0.723379
SIX4 SIX homeobox 4 -0.713666
SET SET nuclear proto-oncogene -0.713468
KIF2C kinesin family member 2C -0.713231
MSH3 mutS homolog 3 -0.713152
PEA15 phosphoprotein enriched in astrocytes 15 -0.712442
FASTKD2 FAST kinase domains 2 -0.710361
SLCO2A1 solute carrier organic anion transporter family, member 2A1 -0.708056
MIS18BP1 MIS18 binding protein 1 -0.707628
ZNF638 zinc finger protein 638 -0.705764
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha -0.703792
PLRG1 pleiotropic regulator 1 -0.702867
ATL3 atlastin GTPase 3 -0.701792
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.699346
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 -0.69866
CHID1 chitinase domain containing 1 -0.697672
RRM2B ribonucleotide reductase M2 B (TP53 inducible) -0.696005
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 -0.695514
CDADC1 cytidine and dCMP deaminase domain containing 1 -0.690153
PDLIM1 PDZ and LIM domain 1 -0.688444
RTCB RNA 2',3'-cyclic phosphate and 5'-OH ligase -0.686595
BCL7C B-cell CLL/lymphoma 7C -0.684092
NFU1 NFU1 iron-sulfur cluster scaffold -0.684019
VKORC1 vitamin K epoxide reductase complex, subunit 1 -0.682156
MYNN myoneurin -0.680956
BUB1 BUB1 mitotic checkpoint serine/threonine kinase -0.671057
TRPM2 transient receptor potential cation channel, subfamily M, member 2 -0.670739
BLOC1S2 biogenesis of lysosomal organelles complex-1, subunit 2 -0.66894
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 -0.668623
NDUFC1 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa -0.665262
TRAPPC13 trafficking protein particle complex 13 -0.663734
OSTF1 osteoclast stimulating factor 1 -0.661912
LEFTY1 left-right determination factor 1 -0.661763
FZD9 frizzled class receptor 9 -0.656051
CLCN4 chloride channel, voltage-sensitive 4 -0.654271
MVB12A multivesicular body subunit 12A -0.651609
TMEM135 transmembrane protein 135 -0.647514
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2 -0.6465
FAM20C family with sequence similarity 20, member C -0.646064
TPMT thiopurine S-methyltransferase -0.645992
IPO5 importin 5 -0.642174
SLC39A5 solute carrier family 39 (zinc transporter), member 5 -0.640105
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.639255
NSUN3 NOP2/Sun domain family, member 3 -0.633831
PHYH phytanoyl-CoA 2-hydroxylase -0.62754
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) -0.619291
CDCA4 cell division cycle associated 4 -0.61789
TMEM50A transmembrane protein 50A -0.611637
NME4 NME/NM23 nucleoside diphosphate kinase 4 -0.610466
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4 -0.605066
KATNBL1 katanin p80 subunit B-like 1 -0.603536
TYMS thymidylate synthetase -0.60202
CALY calcyon neuron-specific vesicular protein -0.598882
NASP nuclear autoantigenic sperm protein (histone-binding) -0.598694
TXNRD3 thioredoxin reductase 3 -0.596142
SLC16A6 solute carrier family 16, member 6 -0.592088
NUDT7 nudix (nucleoside diphosphate linked moiety X)-type motif 7 -0.590989
RILPL2 Rab interacting lysosomal protein-like 2 -0.58911
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 -0.58899
RAP1A RAP1A, member of RAS oncogene family -0.586228
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 -0.58396
TOR2A torsin family 2, member A -0.583721
SYNGR2 synaptogyrin 2 -0.579725
UBIAD1 UbiA prenyltransferase domain containing 1 -0.579608
ACTR1A ARP1 actin-related protein 1 homolog A, centractin alpha (yeast) -0.57809
BRK1 BRICK1, SCAR/WAVE actin-nucleating complex subunit -0.577101
NHP2 NHP2 ribonucleoprotein -0.576177
ETFB electron-transfer-flavoprotein, beta polypeptide -0.573311
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 -0.570805
ZBTB8OS zinc finger and BTB domain containing 8 opposite strand -0.570409
PAOX polyamine oxidase (exo-N4-amino) -0.563989
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) -0.562019
GINS2 GINS complex subunit 2 (Psf2 homolog) -0.560819
ANAPC1 anaphase promoting complex subunit 1 -0.559678
PEX12 peroxisomal biogenesis factor 12 -0.557461
ABHD14B abhydrolase domain containing 14B -0.557193
ZC2HC1B zinc finger, C2HC-type containing 1B -0.553889
GSTP1 glutathione S-transferase pi 1 -0.55099
KRT20 keratin 20, type I -0.546732
OCIAD2 OCIA domain containing 2 -0.545397
EMP3 epithelial membrane protein 3 -0.54372
GPR155 G protein-coupled receptor 155 -0.543414
VDAC1 voltage-dependent anion channel 1 -0.542553
APRT adenine phosphoribosyltransferase -0.54139
MTHFS 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase) -0.535036
TMEM223 transmembrane protein 223 -0.534401
ALDH16A1 aldehyde dehydrogenase 16 family, member A1 -0.534158
CEP55 centrosomal protein 55kDa -0.531257
GALE UDP-galactose-4-epimerase -0.531209
SEC23A Sec23 homolog A (S. cerevisiae) -0.529715
ANAPC4 anaphase promoting complex subunit 4 -0.527253
QPRT quinolinate phosphoribosyltransferase -0.526215
TXN2 thioredoxin 2 -0.525885
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 -0.521797
DCUN1D1 DCN1, defective in cullin neddylation 1, domain containing 1 -0.51451
YDJC YdjC homolog (bacterial) -0.514152
TXN thioredoxin -0.51257
EREG epiregulin -0.510208
PHKA1 phosphorylase kinase, alpha 1 (muscle) -0.506981
ZGPAT zinc finger, CCCH-type with G patch domain -0.506853
UBP1 upstream binding protein 1 (LBP-1a) -0.506086
ASIP agouti signaling protein -0.501677
NME1 NME/NM23 nucleoside diphosphate kinase 1 -0.500267
ACSL1 acyl-CoA synthetase long-chain family member 1 -0.499078
KCTD14 potassium channel tetramerization domain containing 14 -0.49851
CENPW centromere protein W -0.498266
GALM galactose mutarotase (aldose 1-epimerase) -0.49778
NSMCE1 non-SMC element 1 homolog (S. cerevisiae) -0.496727
TOM1L1 target of myb1 (chicken)-like 1 -0.496161
LAX1 lymphocyte transmembrane adaptor 1 -0.495355
ABRACL ABRA C-terminal like -0.492624
MRPS7 mitochondrial ribosomal protein S7 -0.492191
TXNDC17 thioredoxin domain containing 17 -0.491876
GNG10 guanine nucleotide binding protein (G protein), gamma 10 -0.491483
TSPO translocator protein (18kDa) -0.491129
CHCHD10 coiled-coil-helix-coiled-coil-helix domain containing 10 -0.490043
UQCRC2 ubiquinol-cytochrome c reductase core protein II -0.489043
CADM3 cell adhesion molecule 3 -0.488468
IL1A interleukin 1, alpha -0.488429
GPAT2 glycerol-3-phosphate acyltransferase 2, mitochondrial -0.484752
SLC26A5 solute carrier family 26 (anion exchanger), member 5 -0.482999
NUP107 nucleoporin 107kDa -0.48211
IVD isovaleryl-CoA dehydrogenase -0.480071
NXPE2 neurexophilin and PC-esterase domain family, member 2 -0.479454
OSTM1 osteopetrosis associated transmembrane protein 1 -0.478729
WDR48 WD repeat domain 48 -0.478258
ACOT7 acyl-CoA thioesterase 7 -0.476523
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 -0.475498
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast) -0.475111
TSC22D1 TSC22 domain family, member 1 -0.475005
CFP complement factor properdin -0.474513
BCL2L15 BCL2-like 15 -0.472237
PTHLH parathyroid hormone-like hormone -0.470525
ITGB5 integrin, beta 5 -0.469889
SRP9 signal recognition particle 9kDa -0.468986
BMP15 bone morphogenetic protein 15 -0.468618
TAF6 TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa -0.46782
NXF2 nuclear RNA export factor 2 -0.46772
TPCN1 two pore segment channel 1 -0.466789
EVC2 Ellis van Creveld syndrome 2 -0.465847
MIER1 mesoderm induction early response 1, transcriptional regulator -0.464196
HINT1 histidine triad nucleotide binding protein 1 -0.463164
CIB1 calcium and integrin binding 1 (calmyrin) -0.46247
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) -0.462312
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase) -0.462186
SPAG5 sperm associated antigen 5 -0.459524
AMACR alpha-methylacyl-CoA racemase -0.458304
LEPR leptin receptor -0.457817
DCLK2 doublecortin-like kinase 2 -0.457421
KRT81 keratin 81, type II -0.454465
NAAA N-acylethanolamine acid amidase -0.453083
HSPA13 heat shock protein 70kDa family, member 13 -0.452563
PDIA3 protein disulfide isomerase family A, member 3 -0.451733
CTSO cathepsin O -0.451676
KNSTRN kinetochore-localized astrin/SPAG5 binding protein -0.450564
CCDC12 coiled-coil domain containing 12 -0.450535
DNAJC11 DnaJ (Hsp40) homolog, subfamily C, member 11 -0.450478
MTAP methylthioadenosine phosphorylase -0.448438
CTSD cathepsin D -0.447251
APAF1 apoptotic peptidase activating factor 1 -0.446217
CMC1 C-x(9)-C motif containing 1 -0.446056
SACS sacsin molecular chaperone -0.444428
USP38 ubiquitin specific peptidase 38 -0.444109
UBFD1 ubiquitin family domain containing 1 -0.443087
ACADL acyl-CoA dehydrogenase, long chain -0.442752
USP9X ubiquitin specific peptidase 9, X-linked -0.442338
EVI2A ecotropic viral integration site 2A -0.441566
ABI1 abl-interactor 1 -0.44154
NIPBL Nipped-B homolog (Drosophila) -0.441308
MYD88 myeloid differentiation primary response 88 -0.441129
CGRRF1 cell growth regulator with ring finger domain 1 -0.44002
UFD1L ubiquitin fusion degradation 1 like (yeast) -0.438181
IRAK1 interleukin-1 receptor-associated kinase 1 -0.438056
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -0.438007
PNPLA2 patatin-like phospholipase domain containing 2 -0.436899
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1 -0.435342
GALK2 galactokinase 2 -0.43372
SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 -0.433166
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal -0.431301
CRTAP cartilage associated protein -0.429225
SPIC Spi-C transcription factor (Spi-1/PU.1 related) -0.429204
RPL35 ribosomal protein L35 -0.428904
LYSMD3 LysM, putative peptidoglycan-binding, domain containing 3 -0.428455
SCAND1 SCAN domain containing 1 -0.428434
PPP1R21 protein phosphatase 1, regulatory subunit 21 -0.428306
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 -0.42769
TBL2 transducin (beta)-like 2 -0.426928
CR1L complement component (3b/4b) receptor 1-like -0.426908
PCTP phosphatidylcholine transfer protein -0.426805
C2 complement component 2 -0.426476
CEP89 centrosomal protein 89kDa -0.426044
CERS5 ceramide synthase 5 -0.425253
STARD10 StAR-related lipid transfer (START) domain containing 10 -0.425233
CASP12 caspase 12 (gene/pseudogene) -0.424996
SCO2 SCO2 cytochrome c oxidase assembly protein -0.424877
ZNF25 zinc finger protein 25 -0.423752
IMPA1 inositol(myo)-1(or 4)-monophosphatase 1 -0.423633
RPP40 ribonuclease P/MRP 40kDa subunit -0.421423
MAP3K12 mitogen-activated protein kinase kinase kinase 12 -0.065249
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.065213
TCAF1 TRPM8 channel-associated factor 1 -0.064343
INHBA inhibin, beta A -0.062325
DAAM2 dishevelled associated activator of morphogenesis 2 -0.059978
YPEL1 yippee-like 1 (Drosophila) -0.059679
SPATS2 spermatogenesis associated, serine-rich 2 -0.058856
CIC capicua transcriptional repressor -0.058726
TEX15 testis expressed 15 -0.058558
ARL2 ADP-ribosylation factor-like 2 -0.058202
SLC17A2 solute carrier family 17, member 2 -0.057392
CADPS2 Ca++-dependent secretion activator 2 -0.055872
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle) -0.055315
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.05491
CAMK2D calcium/calmodulin-dependent protein kinase II delta -0.054428
TRDMT1 tRNA aspartic acid methyltransferase 1 -0.05439
CHMP2B charged multivesicular body protein 2B -0.05362
PDCD2L programmed cell death 2-like -0.052758
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae) -0.050178
RFTN1 raftlin, lipid raft linker 1 -0.048986
SOX18 SRY (sex determining region Y)-box 18 -0.047378
JARID2 jumonji, AT rich interactive domain 2 -0.04145
ADAM11 ADAM metallopeptidase domain 11 -0.040845
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha -0.040617
NKAIN1 Na+/K+ transporting ATPase interacting 1 -0.040387
CCND3 cyclin D3 -0.037926
AMN1 antagonist of mitotic exit network 1 homolog (S. cerevisiae) -0.03563
MMRN2 multimerin 2 -0.034493
SENP7 SUMO1/sentrin specific peptidase 7 -0.034385
BTBD9 BTB (POZ) domain containing 9 -0.032925
XXYLT1 xyloside xylosyltransferase 1 -0.030973
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit -0.03054
NDUFV3 NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa -0.029729
SCAPER S-phase cyclin A-associated protein in the ER -0.02938
BFSP1 beaded filament structural protein 1, filensin -0.027891
BICD1 bicaudal D homolog 1 (Drosophila) -0.026591
ZBTB43 zinc finger and BTB domain containing 43 -0.026502
OR51B4 olfactory receptor, family 51, subfamily B, member 4 -0.023534
GATAD2B GATA zinc finger domain containing 2B -0.023446
TAGLN3 transgelin 3 -0.022484
PGBD1 piggyBac transposable element derived 1 -0.022328
MKX mohawk homeobox -0.021926
STEAP2 STEAP family member 2, metalloreductase -0.021345
KCTD15 potassium channel tetramerization domain containing 15 -0.021055
RAB2B RAB2B, member RAS oncogene family -0.019593
PRLR prolactin receptor -0.019571
RNF17 ring finger protein 17 -0.01761
FREM1 FRAS1 related extracellular matrix 1 -0.01761
ADAM1B ADAM metallopeptidase domain 1B (pseudogene) -0.01623
NR2C1 nuclear receptor subfamily 2, group C, member 1 -0.01571
FNDC4 fibronectin type III domain containing 4 -0.013069
GAS1 growth arrest-specific 1 -0.012291
TCOF1 Treacher Collins-Franceschetti syndrome 1 -0.010599
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1 -0.009978
CEP57L1 centrosomal protein 57kDa-like 1 -0.009564
PPP1R32 protein phosphatase 1, regulatory subunit 32 -0.008738
FAM160B1 family with sequence similarity 160, member B1 -0.007863
ALKBH5 AlkB family member 5, RNA demethylase -0.005487
NRXN2 neurexin 2 -0.005302
GTPBP4 GTP binding protein 4 -0.005047
BTN1A1 butyrophilin, subfamily 1, member A1 -0.004862
PLCH2 phospholipase C, eta 2 -0.003865
ZFHX3 zinc finger homeobox 3 -0.002545
IL1RL2 interleukin 1 receptor-like 2 -0.002033
Funding