sparc Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description secreted protein, acidic, cysteine-rich (osteonectin)|This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene product has been associated with tumor suppression but has also been correlated with metastasis based on changes to cell shape which can promote tumor cell invasion. [provided by RefSeq, Dec 2011] (NCBI Entrez Gene Database, 6678)
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Genes

70 genes co-occuring with the biological term sparc in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AKT1 v-akt murine thymoma viral oncogene homolog 1
ANPEP alanyl (membrane) aminopeptidase
APAF1 apoptotic peptidase activating factor 1
CAV1 caveolin 1, caveolae protein, 22kDa
CD8A CD8a molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
COL1A1 collagen, type I, alpha 1
CTGF connective tissue growth factor
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTSB cathepsin B
CTSK cathepsin K
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DAPK1 death-associated protein kinase 1
DCN decorin
DCX doublecortin
EDN3 endothelin 3
ERN1 endoplasmic reticulum to nucleus signaling 1
FGA fibrinogen alpha chain
FGFR1 fibroblast growth factor receptor 1
FHIT fragile histidine triad
FN1 fibronectin 1
FOXP3 forkhead box P3
FYN FYN proto-oncogene, Src family tyrosine kinase
GPC3 glypican 3
HSPB1 heat shock 27kDa protein 1
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB4 integrin, beta 4
KLF4 Kruppel-like factor 4 (gut)
LAMC1 laminin, gamma 1 (formerly LAMB2)
MAPK1 mitogen-activated protein kinase 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MIR145 microRNA 145
MIR29A microRNA 29a
MME membrane metallo-endopeptidase
MMP2 matrix metallopeptidase 2
MMP3 matrix metallopeptidase 3
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
MYOC myocilin, trabecular meshwork inducible glucocorticoid response
NLRP2 NLR family, pyrin domain containing 2
PCDH10 protocadherin 10
PTEN phosphatase and tensin homolog
PTPRC protein tyrosine phosphatase, receptor type, C
S100A4 S100 calcium binding protein A4
SATB1 SATB homeobox 1
SFN stratifin
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SLPI secretory leukocyte peptidase inhibitor
SMOC1 SPARC related modular calcium binding 1
SNAI2 snail family zinc finger 2
SOD1 superoxide dismutase 1, soluble
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPP1 secreted phosphoprotein 1
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
STAB1 stabilin 1
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
SULF1 sulfatase 1
TGFB1 transforming growth factor, beta 1
THBS1 thrombospondin 1
THY1 Thy-1 cell surface antigen
TP53 tumor protein p53
TP53INP1 tumor protein p53 inducible nuclear protein 1
TSKU tsukushi, small leucine rich proteoglycan
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VEGFA vascular endothelial growth factor A