sparteine-2790 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the sparteine-2790 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4
ACPP acid phosphatase, prostate
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9
ADM adrenomedullin
AKAP7 A kinase (PRKA) anchor protein 7
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
APOM apolipoprotein M
ARC activity-regulated cytoskeleton-associated protein
ARNT aryl hydrocarbon receptor nuclear translocator
ATF6B activating transcription factor 6 beta
ATG10 autophagy related 10
B9D2 B9 protein domain 2
BAHCC1 BAH domain and coiled-coil containing 1
C1ORF54 chromosome 1 open reading frame 54
C22ORF46 chromosome 22 open reading frame 46
CALCR calcitonin receptor
CAMSAP1 calmodulin regulated spectrin-associated protein 1
CD8A CD8a molecule
CDC42 cell division cycle 42
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant
DCBLD2 discoidin, CUB and LCCL domain containing 2
DCT dopachrome tautomerase
DOCK10 dedicator of cytokinesis 10
EFCAB6 EF-hand calcium binding domain 6
EGFL7 EGF-like-domain, multiple 7
FABP3 fatty acid binding protein 3, muscle and heart
FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2
GABRD gamma-aminobutyric acid (GABA) A receptor, delta
GMPR guanosine monophosphate reductase
GPER1 G protein-coupled estrogen receptor 1
GRAMD1C GRAM domain containing 1C
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4
HES2 hes family bHLH transcription factor 2
HFE hemochromatosis
HN1L hematological and neurological expressed 1-like
HOXC4 homeobox C4
HPX hemopexin
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14
ICA1 islet cell autoantigen 1, 69kDa
IGL immunoglobulin lambda locus
IRS2 insulin receptor substrate 2
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGA8 integrin, alpha 8
KAT6A K(lysine) acetyltransferase 6A
KIAA0754 KIAA0754
LEPR leptin receptor
LIME1 Lck interacting transmembrane adaptor 1
LINC01587 long intergenic non-protein coding RNA 1587
LMF2 lipase maturation factor 2
LRRC75B leucine rich repeat containing 75B
LSP1 lymphocyte-specific protein 1
LTBP2 latent transforming growth factor beta binding protein 2
MAN1C1 mannosidase, alpha, class 1C, member 1
MAPK8 mitogen-activated protein kinase 8
MATN3 matrilin 3
MBNL2 muscleblind-like splicing regulator 2
MERTK MER proto-oncogene, tyrosine kinase
MFI2 antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5
MYOZ1 myozenin 1
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2)
NR0B2 nuclear receptor subfamily 0, group B, member 2
OSBPL1A oxysterol binding protein-like 1A
PACS1 phosphofurin acidic cluster sorting protein 1
PBX2 pre-B-cell leukemia homeobox 2
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
POPDC3 popeye domain containing 3
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic)
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RAD51B RAD51 paralog B
RUNX1 runt-related transcription factor 1
SDC2 syndecan 2
SFRP4 secreted frizzled-related protein 4
SGK2 serum/glucocorticoid regulated kinase 2
SHANK2 SH3 and multiple ankyrin repeat domains 2
SIT1 signaling threshold regulating transmembrane adaptor 1
SKI SKI proto-oncogene
SLC17A2 solute carrier family 17, member 2
SLC35E2 solute carrier family 35, member E2
SLC48A1 solute carrier family 48 (heme transporter), member 1
SOAT2 sterol O-acyltransferase 2
SOX15 SRY (sex determining region Y)-box 15
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3
SSTR5 somatostatin receptor 5
STK16 serine/threonine kinase 16
SUGP1 SURP and G patch domain containing 1
TAGLN transgelin
TBKBP1 TBK1 binding protein 1
TEX14 testis expressed 14
TGM2 transglutaminase 2
THEMIS2 thymocyte selection associated family member 2
THSD4 thrombospondin, type I, domain containing 4
TRAK1 trafficking protein, kinesin binding 1
VAV2 vav 2 guanine nucleotide exchange factor
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
WIPF1 WAS/WASL interacting protein family, member 1
ZNF350 zinc finger protein 350
ZNF589 zinc finger protein 589
ZNF76 zinc finger protein 76

decreased expression

Symbol Name
ABHD17B abhydrolase domain containing 17B
ADAT1 adenosine deaminase, tRNA-specific 1
ALG12 ALG12, alpha-1,6-mannosyltransferase
ALPK1 alpha-kinase 1
C19ORF73 chromosome 19 open reading frame 73
C1ORF159 chromosome 1 open reading frame 159
C4ORF29 chromosome 4 open reading frame 29
C5AR2 complement component 5a receptor 2
CAMK1 calcium/calmodulin-dependent protein kinase I
CARF calcium responsive transcription factor
CCDC132 coiled-coil domain containing 132
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CENPI centromere protein I
COPZ2 coatomer protein complex, subunit zeta 2
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DCP1A decapping mRNA 1A
DENND4C DENN/MADD domain containing 4C
DGAT1 diacylglycerol O-acyltransferase 1
DGKE diacylglycerol kinase, epsilon 64kDa
EFNA3 ephrin-A3
EHBP1L1 EH domain binding protein 1-like 1
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
EPHX2 epoxide hydrolase 2, cytoplasmic
ERCC4 excision repair cross-complementation group 4
EVPL envoplakin
FAM169A family with sequence similarity 169, member A
FBXW12 F-box and WD repeat domain containing 12
FGD1 FYVE, RhoGEF and PH domain containing 1
FKBP14 FK506 binding protein 14, 22 kDa
GINS4 GINS complex subunit 4 (Sld5 homolog)
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GPX2 glutathione peroxidase 2
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa
GUSBP3 glucuronidase, beta pseudogene 3
HIRA histone cell cycle regulator
HIST1H1D histone cluster 1, H1d
HIST1H1E histone cluster 1, H1e
HIST1H2AJ histone cluster 1, H2aj
HIST1H3E histone cluster 1, H3e
HIST2H2AA3 histone cluster 2, H2aa3
HLA-J major histocompatibility complex, class I, J (pseudogene)
IFNAR1 interferon (alpha, beta and omega) receptor 1
IPP intracisternal A particle-promoted polypeptide
IRAK4 interleukin-1 receptor-associated kinase 4
KCTD7 potassium channel tetramerization domain containing 7
KLF2 Kruppel-like factor 2
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
LZTS3 leucine zipper, putative tumor suppressor family member 3
MBTD1 mbt domain containing 1
MPHOSPH8 M-phase phosphoprotein 8
MRPS18C mitochondrial ribosomal protein S18C
MT1H metallothionein 1H
NBEAL2 neurobeachin-like 2
NDRG4 NDRG family member 4
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NT5E 5'-nucleotidase, ecto (CD73)
OSMR oncostatin M receptor
PDIA3 protein disulfide isomerase family A, member 3
PHACTR4 phosphatase and actin regulator 4
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PLA2G3 phospholipase A2, group III
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
PPDPF pancreatic progenitor cell differentiation and proliferation factor
PRICKLE3 prickle homolog 3 (Drosophila)
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RFWD3 ring finger and WD repeat domain 3
RIPK4 receptor-interacting serine-threonine kinase 4
SAYSD1 SAYSVFN motif domain containing 1
SCAI suppressor of cancer cell invasion
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SLC44A1 solute carrier family 44 (choline transporter), member 1
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma)
STRN striatin, calmodulin binding protein
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TARP TCR gamma alternate reading frame protein
THAP9 THAP domain containing 9
TMEM209 transmembrane protein 209
TNS2 tensin 2
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae)
UBQLN4 ubiquilin 4
VEZT vezatin, adherens junctions transmembrane protein
WDR76 WD repeat domain 76
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
ZNF160 zinc finger protein 160
ZNF205 zinc finger protein 205
ZNF428 zinc finger protein 428
ZNF552 zinc finger protein 552
ZNF611 zinc finger protein 611
ZNF652 zinc finger protein 652
ZNF665 zinc finger protein 665
ZNF721 zinc finger protein 721
ZNF787 zinc finger protein 787