specific granule Gene Set

Dataset GO Cellular Component Annotations 2025
Category structural or functional annotations
Type cellular component
Description Granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase. (Gene Ontology, GO_0042581)
External Link http://amigo.geneontology.org/amigo/term/GO:0042581
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Genes

160 proteins localized to the specific granule cellular component from the curated GO Cellular Component Annotations 2025 dataset.

Symbol Name
ACAA1 acetyl-CoA acyltransferase 1
ADAM10 ADAM metallopeptidase domain 10
ADAM8 ADAM metallopeptidase domain 8
ADGRG3 adhesion G protein-coupled receptor G3
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2
AIFM2 apoptosis-inducing factor, mitochondrion-associated, 2
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
ANO6 anoctamin 6
ANXA11 annexin A11
ANXA3 annexin A3
AOC1 amine oxidase, copper containing 1
AP1M1 adaptor-related protein complex 1, mu 1 subunit
ARMC8 armadillo repeat containing 8
ATP11A ATPase, class VI, type 11A
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
ATP8B4 ATPase, class I, type 8B, member 4
B2M beta-2-microglobulin
BPI bactericidal/permeability-increasing protein
C3AR1 complement component 3a receptor 1
CANT1 calcium activated nucleotidase 1
CD177 CD177 molecule
CD33 CD33 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD47 CD47 molecule
CD53 CD53 molecule
CD59 CD59 molecule, complement regulatory protein
CD93 CD93 molecule
CDC50A cell division cycle 50 P4-ATPase accessory subunit A
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM21 carcinoembryonic antigen-related cell adhesion molecule 21
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8
CEP290 centrosomal protein 290kDa
CFP complement factor properdin
CHAMP1 chromosome alignment maintaining phosphoprotein 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIT1 chitinase 1 (chitotriosidase)
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal)
CKAP4 cytoskeleton-associated protein 4
CLCN3 chloride channel, voltage-sensitive 3
CLEC12A C-type lectin domain family 12, member A
CLEC4D C-type lectin domain family 4, member D
CLEC5A C-type lectin domain family 5, member A
CMTM6 CKLF-like MARVEL transmembrane domain containing 6
CNN2 calponin 2
CRACR2A calcium release activated channel regulator 2A
CRISP3 cysteine-rich secretory protein 3
CTSD cathepsin D
CTSZ cathepsin Z
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CYBA cytochrome b-245, alpha polypeptide
CYBB cytochrome b-245, beta polypeptide
CYFIP1 cytoplasmic FMR1 interacting protein 1
DEFA4 defensin, alpha 4, corticostatin
DEGS1 delta(4)-desaturase, sphingolipid 1
DGAT1 diacylglycerol O-acyltransferase 1
DLC1 DLC1 Rho GTPase activating protein
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5
DNASE1L1 deoxyribonuclease I-like 1
DOCK2 dedicator of cytokinesis 2
EGFL7 EGF-like-domain, multiple 7
ELANE elastase, neutrophil expressed
ERP44 endoplasmic reticulum protein 44
FCAR Fc fragment of IgA receptor
FOLR3 folate receptor 3 (gamma)
FPR2 formyl peptide receptor 2
FRK fyn-related Src family tyrosine kinase
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GHDC GH3 domain containing
GPR84 G protein-coupled receptor 84
GSDMD gasdermin D
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase
HMOX2 heme oxygenase 2
HPSE heparanase
HVCN1 hydrogen voltage gated channel 1
ILF2 interleukin enhancer binding factor 2
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITGAV integrin, alpha V
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
JUP junction plakoglobin
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2
KPNB1 karyopherin (importin) beta 1
LAIR1 leukocyte-associated immunoglobulin-like receptor 1
LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
LAMTOR2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
LCN2 lipocalin 2
LILRA3 leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3
LRG1 leucine-rich alpha-2-glycoprotein 1
LRRC7 leucine rich repeat containing 7
LTF lactotransferrin
LYZ lysozyme
MCEMP1 mast cell-expressed membrane protein 1
MLEC malectin
MMP28 matrix metallopeptidase 28
MMP8 matrix metallopeptidase 8
MOSPD2 motile sperm domain containing 2
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NIT2 nitrilase family, member 2
OLFM4 olfactomedin 4
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
ORM1 orosomucoid 1
ORM2 orosomucoid 2
ORMDL3 ORMDL sphingolipid biosynthesis regulator 3
OSCAR osteoclast associated, immunoglobulin-like receptor
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PGAP1 post-GPI attachment to proteins 1
PGLYRP1 peptidoglycan recognition protein 1
PGRMC1 progesterone receptor membrane component 1
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PRKCSH protein kinase C substrate 80K-H
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTPRB protein tyrosine phosphatase, receptor type, B
PTPRJ protein tyrosine phosphatase, receptor type, J
PTX3 pentraxin 3, long
QPCT glutaminyl-peptide cyclotransferase
QSOX1 quiescin Q6 sulfhydryl oxidase 1
RAB27A RAB27A, member RAS oncogene family
RAB37 RAB37, member RAS oncogene family
RAB44 RAB44, member RAS oncogene family
RAP1A RAP1A, member of RAS oncogene family
RAP2B RAP2B, member of RAS oncogene family
RETN resistin
SCAMP1 secretory carrier membrane protein 1
SLC15A4 solute carrier family 15 (oligopeptide transporter), member 4
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC44A2 solute carrier family 44 (choline transporter), member 2
SLCO4C1 solute carrier organic anion transporter family, member 4C1
SLPI secretory leukocyte peptidase inhibitor
SNAP23 synaptosomal-associated protein, 23kDa
SNAP25 synaptosomal-associated protein, 25kDa
SPTAN1 spectrin, alpha, non-erythrocytic 1
STK10 serine/threonine kinase 10
STOM stomatin
STX3 syntaxin 3
STX4 syntaxin 4
STXBP2 syntaxin binding protein 2
STXBP3 syntaxin binding protein 3
TARM1 T cell-interacting, activating receptor on myeloid cells 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TIMP2 TIMP metallopeptidase inhibitor 2
TINAGL1 tubulointerstitial nephritis antigen-like 1
TMBIM1 transmembrane BAX inhibitor motif containing 1
TMC6 transmembrane channel-like 6
TMEM63A transmembrane protein 63A
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TOLLIP toll interacting protein
TOM1 target of myb1 (chicken)
TRPM2 transient receptor potential cation channel, subfamily M, member 2
TSPAN14 tetraspanin 14
UBR4 ubiquitin protein ligase E3 component n-recognin 4
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VAMP8 vesicle-associated membrane protein 8
VCL vinculin