spectrin Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description Membrane associated dimeric protein (240 and 220 kDa) of erythrocytes. Forms a complex with ankyrin, actin and probably other components of the membrane cytoskeleton, so that there is a mesh of proteins underlying the plasma membrane, potentially restricting the lateral mobility of integral proteins. (Gene Ontology, GO_0008091)
Similar Terms
Downloads & Tools

Genes

232 proteins co-occuring with the spectrin cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
EPB41 erythrocyte membrane protein band 4.1 3.1046
ANK1 ankyrin 1, erythrocytic 3.06909
SPTB spectrin, beta, erythrocytic 2.88775
SPTA1 spectrin, alpha, erythrocytic 1 2.04231
SPTAN1 spectrin, alpha, non-erythrocytic 1 1.98621
DMD dystrophin 1.95442
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 1.89247
DNM2 dynamin 2 1.74701
CAST calpastatin 1.63777
GYPE glycophorin E (MNS blood group) 1.55764
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 1.54914
SPTBN1 spectrin, beta, non-erythrocytic 1 1.53726
ANK2 ankyrin 2, neuronal 1.52879
CALM2 calmodulin 2 (phosphorylase kinase, delta) 1.40075
CALM3 calmodulin 3 (phosphorylase kinase, delta) 1.40075
CALM1 calmodulin 1 (phosphorylase kinase, delta) 1.40019
DMTN dematin actin binding protein 1.30819
UTRN utrophin 1.2921
SPTBN2 spectrin, beta, non-erythrocytic 2 1.2825
EPB41L1 erythrocyte membrane protein band 4.1-like 1 1.2777
ADD2 adducin 2 (beta) 1.25811
EPB41L2 erythrocyte membrane protein band 4.1-like 2 1.22257
SYNE1 spectrin repeat containing, nuclear envelope 1 1.2148
SPTBN4 spectrin, beta, non-erythrocytic 4 1.19726
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.1685
ADD1 adducin 1 (alpha) 1.16338
GYPC glycophorin C (Gerbich blood group) 1.14187
VCL vinculin 1.1148
TPM1 tropomyosin 1 (alpha) 1.09136
PLS1 plastin 1 1.04783
PLEK pleckstrin 1.01784
CAPN2 calpain 2, (m/II) large subunit 1.00448
ACTN2 actinin, alpha 2 0.954961
MACF1 microtubule-actin crosslinking factor 1 0.946382
NFASC neurofascin 0.935488
CSN1S1 casein alpha s1 0.928422
TMOD1 tropomodulin 1 0.927013
EPB42 erythrocyte membrane protein band 4.2 0.922791
SRC SRC proto-oncogene, non-receptor tyrosine kinase 0.920918
SYN1 synapsin I 0.912977
KALRN kalirin, RhoGEF kinase 0.858014
SPTBN5 spectrin, beta, non-erythrocytic 5 0.803396
SLC4A3 solute carrier family 4 (anion exchanger), member 3 0.785071
ADD3 adducin 3 (gamma) 0.770907
MCF2 MCF.2 cell line derived transforming sequence 0.744574
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.743671
DNAH8 dynein, axonemal, heavy chain 8 0.739163
ACTN4 actinin, alpha 4 0.716791
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 0.712795
TTN titin 0.673328
MAP2 microtubule-associated protein 2 0.65259
NRCAM neuronal cell adhesion molecule 0.636295
GSN gelsolin 0.616285
MARCKS myristoylated alanine-rich protein kinase C substrate 0.611625
DST dystonin 0.607395
SESTD1 SEC14 and spectrin domains 1 0.604862
UBC ubiquitin C 0.581758
RHAG Rh-associated glycoprotein 0.581758
GRIA1 glutamate receptor, ionotropic, AMPA 1 0.575078
CDK5 cyclin-dependent kinase 5 0.572578
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.562187
RPS27A ribosomal protein S27a 0.5568
ACTN1 actinin, alpha 1 0.5568
UBB ubiquitin B 0.540706
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.527569
ACTG1 actin gamma 1 0.527569
GAS2 growth arrest-specific 2 0.521023
PLEKHG3 pleckstrin homology domain containing, family G (with RhoGef domain) member 3 0.518981
PFN4 profilin family, member 4 0.51694
DCTN1 dynactin 1 0.511233
CAMSAP1 calmodulin regulated spectrin-associated protein 1 0.504724
TRPC4 transient receptor potential cation channel, subfamily C, member 4 0.504318
PFN2 profilin 2 0.501881
PDLIM3 PDZ and LIM domain 3 0.500664
ZNF251 zinc finger protein 251 0.500258
EZR ezrin 0.499853
PFN1 profilin 1 0.484079
ZNF333 zinc finger protein 333 0.475223
FLNA filamin A, alpha 0.457606
DSP desmoplakin 0.457208
RHBG Rh family, B glycoprotein (gene/pseudogene) 0.444878
ACHE acetylcholinesterase (Yt blood group) 0.442896
L1CAM L1 cell adhesion molecule 0.44052
POU3F4 POU class 3 homeobox 4 0.44052
FLOT2 flotillin 2 0.440124
ALB albumin 0.439333
GSTA3 glutathione S-transferase alpha 3 0.436565
GSTA2 glutathione S-transferase alpha 2 0.434985
GSTA4 glutathione S-transferase alpha 4 0.434985
GSTA1 glutathione S-transferase alpha 1 0.432618
PKLR pyruvate kinase, liver and RBC 0.429072
PRDX2 peroxiredoxin 2 0.420036
FYN FYN proto-oncogene, Src family tyrosine kinase 0.41886
G6PD glucose-6-phosphate dehydrogenase 0.41612
PTBP3 polypyrimidine tract binding protein 3 0.412992
PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit 0.410649
ACTB actin, beta 0.407919
PAM peptidylglycine alpha-amidating monooxygenase 0.407919
EMD emerin 0.405971
STOM stomatin 0.385051
SYNE3 spectrin repeat containing, nuclear envelope family member 3 0.384665
LDB3 LIM domain binding 3 0.383124
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1 0.382354
INA internexin neuronal intermediate filament protein, alpha 0.37505
ANXA2 annexin A2 0.367006
SGCA sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) 0.359371
BCAM basal cell adhesion molecule (Lutheran blood group) 0.359371
MAPT microtubule-associated protein tau 0.357086
ATP11A ATPase, class VI, type 11A 0.355183
PRX periaxin 0.353662
PKM pyruvate kinase, muscle 0.351002
SORBS3 sorbin and SH3 domain containing 3 0.350243
FANCA Fanconi anemia, complementation group A 0.341907
TMOD3 tropomodulin 3 (ubiquitous) 0.334733
CPAMD8 C3 and PZP-like, alpha-2-macroglobulin domain containing 8 0.332848
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.327956
SH3PXD2A SH3 and PX domains 2A 0.324201
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) 0.323825
AHNAK AHNAK nucleoprotein 0.3227
TUBA1A tubulin, alpha 1a 0.318579
PYHIN1 pyrin and HIN domain family, member 1 0.315586
FN1 fibronectin 1 0.313718
DPYSL2 dihydropyrimidinase-like 2 0.309613
PLA2G1B phospholipase A2, group IB (pancreas) 0.306632
CAPNS1 calpain, small subunit 1 0.30626
GLDN gliomedin 0.303655
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 0.30254
CNTNAP1 contactin associated protein 1 0.298826
SLC1A6 solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6 0.296601
HBE1 hemoglobin, epsilon 1 0.295119
LDHD lactate dehydrogenase D 0.293267
PPL periplakin 0.292897
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein 0.291047
FRMD3 FERM domain containing 3 0.287352
PCDH19 protocadherin 19 0.286245
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) 0.285507
SSH3 slingshot protein phosphatase 3 0.285138
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.283663
LIN52 lin-52 DREAM MuvB core complex component 0.281821
IQGAP1 IQ motif containing GTPase activating protein 1 0.281453
ANKRD26 ankyrin repeat domain 26 0.277774
ANXA1 annexin A1 0.2708
SCN1A sodium channel, voltage gated, type I alpha subunit 0.269701
NCKAP1L NCK-associated protein 1-like 0.266408
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 0.265677
THAP3 THAP domain containing, apoptosis associated protein 3 0.263485
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) 0.26239
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.26166
RDX radixin 0.260566
ARX aristaless related homeobox 0.259473
MAP4 microtubule-associated protein 4 0.258381
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome 0.254743
EPB41L4A erythrocyte membrane protein band 4.1 like 4A 0.252564
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) 0.251114
MGAM maltase-glucoamylase 0.24424
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.243519
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2 0.242797
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma 0.240276
XK X-linked Kx blood group 0.239197
ACKR1 atypical chemokine receptor 1 (Duffy blood group) 0.238119
MSN moesin 0.236683
DAND5 DAN domain family member 5, BMP antagonist 0.236683
AQP1 aquaporin 1 (Colton blood group) 0.236324
CALD1 caldesmon 1 0.234891
MCF2L MCF.2 cell line derived transforming sequence-like 0.234533
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 0.233817
GBP1 guanylate binding protein 1, interferon-inducible 0.233459
BAX BCL2-associated X protein 0.231315
SLC8A3 solute carrier family 8 (sodium/calcium exchanger), member 3 0.229176
MAP1B microtubule-associated protein 1B 0.227397
PKP4 plakophilin 4 0.224558
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa 0.223143
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2 0.222436
ACT actin-like protein (ACT) gene 0.218914
GFAP glial fibrillary acidic protein 0.218563
PLEK2 pleckstrin 2 0.218212
TRPC5 transient receptor potential cation channel, subfamily C, member 5 0.217861
LST1 leukocyte specific transcript 1 0.21716
POTEF POTE ankyrin domain family, member F 0.21681
LAMA2 laminin, alpha 2 0.21646
FANCC Fanconi anemia, complementation group C 0.216111
MYH1 myosin, heavy chain 1, skeletal muscle, adult 0.211933
FLNC filamin C, gamma 0.210203
MYLK myosin light chain kinase 0.209513
TMEM53 transmembrane protein 53 0.207794
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22 0.206766
OAF OAF homolog (Drosophila) 0.206082
SCN8A sodium channel, voltage gated, type VIII alpha subunit 0.204718
CLMN calmin (calponin-like, transmembrane) 0.204039
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.200999
FLOT1 flotillin 1 0.200663
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase 0.197662
LMNA lamin A/C 0.196669
COX7B cytochrome c oxidase subunit VIIb 0.19601
ZFYVE1 zinc finger, FYVE domain containing 1 0.194698
CAPN10 calpain 10 0.1921
CD47 CD47 molecule 0.1921
EVL Enah/Vasp-like 0.190175
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.189539
TMOD2 tropomodulin 2 (neuronal) 0.18859
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1 0.187646
EVPL envoplakin 0.184853
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1 0.18093
PLEKHG4 pleckstrin homology domain containing, family G (with RhoGef domain) member 4 0.178011
PLEC plectin 0.178011
SLC4A10 solute carrier family 4, sodium bicarbonate transporter, member 10 0.17687
MST1 macrophage stimulating 1 0.176305
NUMA1 nuclear mitotic apparatus protein 1 0.176024
HBB hemoglobin, beta 0.174911
TSPAN2 tetraspanin 2 0.174911
CADM4 cell adhesion molecule 4 0.174635
CAMK2G calcium/calmodulin-dependent protein kinase II gamma 0.173543
NEFL neurofilament, light polypeptide 0.171673
TMOD4 tropomodulin 4 (muscle) 0.17141
KEL Kell blood group, metallo-endopeptidase 0.168847
APCS amyloid P component, serum 0.168598
DCTN4 dynactin 4 (p62) 0.165697
FTL ferritin, light polypeptide 0.165463
PDLIM1 PDZ and LIM domain 1 0.164315
FTH1 ferritin, heavy polypeptide 1 0.164315
EPO erythropoietin 0.164315
ARL6IP4 ADP-ribosylation factor-like 6 interacting protein 4 0.16233
ERCC4 excision repair cross-complementation group 4 0.161905
NEFM neurofilament, medium polypeptide 0.161068
ARHGAP44 Rho GTPase activating protein 44 0.160658
LCP1 lymphocyte cytosolic protein 1 (L-plastin) 0.159268
RIPK4 receptor-interacting serine-threonine kinase 4 0.159074
ARHGAP9 Rho GTPase activating protein 9 0.158502
CRB1 crumbs family member 1, photoreceptor morphogenesis associated 0.158315
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.158129
LYN LYN proto-oncogene, Src family tyrosine kinase 0.157943
PNPO pyridoxamine 5'-phosphate oxidase 0.156342