sphingolipid catabolic process Gene Set

Dataset GO Biological Process Annotations 2025
Category structural or functional annotations
Type biological process
Description The chemical reactions and pathways resulting in the breakdown of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). (Gene Ontology, GO_0030149)
External Link http://amigo.geneontology.org/amigo/term/GO:0030149
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Genes

33 genes participating in the sphingolipid catabolic process biological process from the curated GO Biological Process Annotations 2025 dataset.

Symbol Name
ACER1 alkaline ceramidase 1
ACER2 alkaline ceramidase 2
ACER3 alkaline ceramidase 3
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
ALDH3B2 aldehyde dehydrogenase 3 family, member B2
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2
CEL carboxyl ester lipase
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ENPP7 ectonucleotide pyrophosphatase/phosphodiesterase 7
GALC galactosylceramidase
GBA2 glucosidase, beta (bile acid) 2
GBA3 glucosidase, beta, acid 3 (gene/pseudogene)
GLB1 galactosidase, beta 1
GM2A GM2 ganglioside activator
M6PR mannose-6-phosphate receptor (cation dependent)
NAT8 N-acetyltransferase 8 (GCN5-related, putative)
NEU2 sialidase 2 (cytosolic sialidase)
NEU3 sialidase 3 (membrane sialidase)
PLPP1 phospholipid phosphatase 1
PLPP2 phospholipid phosphatase 2
PLPP3 phospholipid phosphatase 3
PPT1 palmitoyl-protein thioesterase 1
SGPL1 sphingosine-1-phosphate lyase 1
SGPP1 sphingosine-1-phosphate phosphatase 1
SGPP2 sphingosine-1-phosphate phosphatase 2
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
SMPD4 sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SPHK1 sphingosine kinase 1
SUMF1 sulfatase modifying factor 1