sphingolipid metabolic process Gene Set

Dataset GO Biological Process Annotations 2025
Category structural or functional annotations
Type biological process
Description The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). (Gene Ontology, GO_0006665)
External Link http://amigo.geneontology.org/amigo/term/GO:0006665
Similar Terms
Downloads & Tools

Genes

80 genes participating in the sphingolipid metabolic process biological process from the curated GO Biological Process Annotations 2025 dataset.

Symbol Name
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACER1 alkaline ceramidase 1
ACER2 alkaline ceramidase 2
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
ALDH3B2 aldehyde dehydrogenase 3 family, member B2
ALOX12B arachidonate 12-lipoxygenase, 12R type
ALOXE3 arachidonate lipoxygenase 3
ARV1 ARV1 homolog (S. cerevisiae)
ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1
CERK ceramide kinase
CERKL ceramide kinase-like
CERS1 ceramide synthase 1
CERS2 ceramide synthase 2
CERS3 ceramide synthase 3
CERS4 ceramide synthase 4
CERS6 ceramide synthase 6
CLN8 ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
CSNK1G2 casein kinase 1, gamma 2
DEGS1 delta(4)-desaturase, sphingolipid 1
DEGS2 delta(4)-desaturase, sphingolipid 2
ELOVL1 ELOVL fatty acid elongase 1
ELOVL2 ELOVL fatty acid elongase 2
ELOVL3 ELOVL fatty acid elongase 3
ELOVL4 ELOVL fatty acid elongase 4
ELOVL5 ELOVL fatty acid elongase 5
ELOVL6 ELOVL fatty acid elongase 6
ELOVL7 ELOVL fatty acid elongase 7
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ENPP7 ectonucleotide pyrophosphatase/phosphodiesterase 7
FA2H fatty acid 2-hydroxylase
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)
FUT5 fucosyltransferase 5 (alpha (1,3) fucosyltransferase)
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
FUT7 fucosyltransferase 7 (alpha (1,3) fucosyltransferase)
GAL3ST1 galactose-3-O-sulfotransferase 1
HACD1 3-hydroxyacyl-CoA dehydratase 1
HACD2 3-hydroxyacyl-CoA dehydratase 2
HACD3 3-hydroxyacyl-CoA dehydratase 3
HACD4 3-hydroxyacyl-CoA dehydratase 4
KDSR 3-ketodihydrosphingosine reductase
MFSD2B major facilitator superfamily domain containing 2B
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
ORMDL1 ORMDL sphingolipid biosynthesis regulator 1
ORMDL2 ORMDL sphingolipid biosynthesis regulator 2
ORMDL3 ORMDL sphingolipid biosynthesis regulator 3
PLA2G15 phospholipase A2, group XV
PLPP1 phospholipid phosphatase 1
PLPP2 phospholipid phosphatase 2
PLPP3 phospholipid phosphatase 3
PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L
PPT1 palmitoyl-protein thioesterase 1
PRKD1 protein kinase D1
PRKD2 protein kinase D2
PRKD3 protein kinase D3
SERINC1 serine incorporator 1
SGMS1 sphingomyelin synthase 1
SGMS2 sphingomyelin synthase 2
SGPL1 sphingosine-1-phosphate lyase 1
SGPP1 sphingosine-1-phosphate phosphatase 1
SGPP2 sphingosine-1-phosphate phosphatase 2
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
SPHK1 sphingosine kinase 1
SPHK2 sphingosine kinase 2
SPNS2 spinster homolog 2 (Drosophila)
SPTLC1 serine palmitoyltransferase, long chain base subunit 1
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
SPTSSA serine palmitoyltransferase, small subunit A
SPTSSB serine palmitoyltransferase, small subunit B
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
ST6GALNAC6 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
TECR trans-2,3-enoyl-CoA reductase
TEX2 testis expressed 2
TM9SF2 transmembrane 9 superfamily member 2