spina bifida Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
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Genes

263 genes co-occuring with the disease spina bifida in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
AFP alpha-fetoprotein 2.2463
GRHL3 grainyhead-like 3 (Drosophila) 1.88436
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 1.63545
C11ORF31 chromosome 11 open reading frame 31 1.55468
ZIC1 Zic family member 1 1.52996
PAX3 paired box 3 1.43991
ACHE acetylcholinesterase (Yt blood group) 1.39433
ZC3H6 zinc finger CCCH-type containing 6 1.39302
VANGL1 VANGL planar cell polarity protein 1 1.3869
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 1.32672
SCRIB scribbled planar cell polarity protein 1.31668
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase 1.3027
TCP10L2 t-complex 10-like 2 1.28217
FKBP8 FK506 binding protein 8, 38kDa 1.27606
PRMT9 protein arginine methyltransferase 9 1.22605
UNCX UNC homeobox 1.22605
COL23A1 collagen, type XXIII, alpha 1 1.22605
ITPK1 inositol-tetrakisphosphate 1-kinase 1.22605
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 1.21782
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1 1.20959
ZIC2 Zic family member 2 1.15155
VANGL2 VANGL planar cell polarity protein 2 1.14093
MNX1 motor neuron and pancreas homeobox 1 1.13585
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 1.10931
IFT52 intraflagellar transport 52 1.09419
DPF1 D4, zinc and double PHD fingers family 1 1.08873
TCP10 t-complex 10 1.08873
TMEM184C transmembrane protein 184C 1.08789
ACTL6B actin-like 6B 1.08663
PAX1 paired box 1 1.0795
ITFG1 integrin alpha FG-GAP repeat containing 1 1.06354
FOLR1 folate receptor 1 (adult) 1.04167
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 1.03535
FUZ fuzzy planar cell polarity protein 1.03156
ACTL6A actin-like 6A 1.02271
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase 1.01343
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase 1.01343
RARG retinoic acid receptor, gamma 0.957033
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase) 0.954525
SHH sonic hedgehog 0.94577
ZIC4 Zic family member 4 0.922974
SRPRB signal recognition particle receptor, B subunit 0.918024
FOLR2 folate receptor 2 (fetal) 0.914315
CECR2 cat eye syndrome chromosome region, candidate 2 0.898693
TCTE1 t-complex-associated-testis-expressed 1 0.887208
ALDH3B2 aldehyde dehydrogenase 3 family, member B2 0.870006
NRL neural retina leucine zipper 0.866731
TGS1 trimethylguanosine synthase 1 0.865093
FOXN1 forkhead box N1 0.858134
ZIC3 Zic family member 3 0.844621
DSEL dermatan sulfate epimerase-like 0.838476
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 0.838066
PCOLCE2 procollagen C-endopeptidase enhancer 2 0.837246
SOX3 SRY (sex determining region Y)-box 3 0.827819
NUAK2 NUAK family, SNF1-like kinase, 2 0.825358
WNT11 wingless-type MMTV integration site family, member 11 0.820437
BHMT betaine--homocysteine S-methyltransferase 0.813873
DHFR dihydrofolate reductase 0.806077
PFN1 profilin 1 0.804026
MS4A2 membrane-spanning 4-domains, subfamily A, member 2 0.798692
INMT indolethylamine N-methyltransferase 0.781479
TBX6 T-box 6 0.777795
CBS cystathionine-beta-synthase 0.772887
PHF10 PHD finger protein 10 0.768393
NF1 neurofibromin 1 0.758601
TULP3 tubby like protein 3 0.756971
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.756564
TRDMT1 tRNA aspartic acid methyltransferase 1 0.750864
CYP26C1 cytochrome P450, family 26, subfamily C, polypeptide 1 0.74883
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 0.745172
PFN4 profilin family, member 4 0.744766
SMC2 structural maintenance of chromosomes 2 0.743141
IFT140 intraflagellar transport 140 0.736243
FZD6 frizzled class receptor 6 0.731381
ATP11C ATPase, class VI, type 11C 0.718443
MYH4 myosin, heavy chain 4, skeletal muscle 0.715618
ODF2 outer dense fiber of sperm tails 2 0.712796
PCOLCE procollagen C-endopeptidase enhancer 0.709975
NKX2-8 NK2 homeobox 8 0.707961
VAX2 ventral anterior homeobox 2 0.707559
MAP3K4 mitogen-activated protein kinase kinase kinase 4 0.6939
SHROOM3 shroom family member 3 0.692296
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14 0.683093
PFN2 profilin 2 0.673917
NAP1L2 nucleosome assembly protein 1-like 2 0.667947
SEC24B SEC24 family member B 0.663975
PCDH8 protocadherin 8 0.66199
ZFYVE27 zinc finger, FYVE domain containing 27 0.661594
ISYNA1 inositol-3-phosphate synthase 1 0.658026
SMTNL1 smoothelin-like 1 0.654067
TRPM6 transient receptor potential cation channel, subfamily M, member 6 0.646953
BHMT2 betaine--homocysteine S-methyltransferase 2 0.633956
CDX4 caudal type homeobox 4 0.631205
PRICKLE2 prickle homolog 2 (Drosophila) 0.614356
GRHL2 grainyhead-like 2 (Drosophila) 0.611229
NOG noggin 0.609276
PLXNA2 plexin A2 0.608494
ALX1 ALX homeobox 1 0.604201
ISL1 ISL LIM homeobox 1 0.60147
DACT1 dishevelled-binding antagonist of beta-catenin 1 0.596402
HSF4 heat shock transcription factor 4 0.573828
BCHE butyrylcholinesterase 0.571884
MARCKSL1 MARCKS-like 1 0.571495
GPC6 glypican 6 0.569163
HIAT1 hippocampus abundant transcript 1 0.554403
HES7 hes family bHLH transcription factor 7 0.540055
DVL1 dishevelled segment polarity protein 1 0.540055
ST7 suppression of tumorigenicity 7 0.53928
ROR2 receptor tyrosine kinase-like orphan receptor 2 0.535409
GGT7 gamma-glutamyltransferase 7 0.532314
HOXD4 homeobox D4 0.527676
SLC5A11 solute carrier family 5 (sodium/inositol cotransporter), member 11 0.523045
SHMT1 serine hydroxymethyltransferase 1 (soluble) 0.51919
ST18 suppression of tumorigenicity 18, zinc finger 0.518805
CUBN cubilin (intrinsic factor-cobalamin receptor) 0.51611
SARDH sarcosine dehydrogenase 0.514571
PTGDS prostaglandin D2 synthase 21kDa (brain) 0.513417
RNF2 ring finger protein 2 0.510728
SUZ12 SUZ12 polycomb repressive complex 2 subunit 0.509192
WNT3A wingless-type MMTV integration site family, member 3A 0.504973
PARD3 par-3 family cell polarity regulator 0.502292
OR5K1 olfactory receptor, family 5, subfamily K, member 1 0.498085
WNT5A wingless-type MMTV integration site family, member 5A 0.497321
LIG3 ligase III, DNA, ATP-dependent 0.495793
ALDH1L1 aldehyde dehydrogenase 1 family, member L1 0.491215
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.488169
JARID2 jumonji, AT rich interactive domain 2 0.488169
DSE dermatan sulfate epimerase 0.487407
PRICKLE1 prickle homolog 1 (Drosophila) 0.486646
PTCH1 patched 1 0.483985
ELSPBP1 epididymal sperm binding protein 1 0.483224
GCSH glycine cleavage system protein H (aminomethyl carrier) 0.482464
SLC7A4 solute carrier family 7, member 4 0.482464
PTER phosphotriesterase related 0.478289
TEAD2 TEA domain family member 2 0.475634
NUAK1 NUAK family, SNF1-like kinase, 1 0.471846
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 0.470711
SRSF5 serine/arginine-rich splicing factor 5 0.458241
OR4F29 olfactory receptor, family 4, subfamily F, member 29 0.457109
LRP6 low density lipoprotein receptor-related protein 6 0.449947
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial) 0.446182
CISD2 CDGSH iron sulfur domain 2 0.443923
PRKACB protein kinase, cAMP-dependent, catalytic, beta 0.443547
SP8 Sp8 transcription factor 0.443171
HOXB1 homeobox B1 0.442042
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 0.44129
HOXC8 homeobox C8 0.439786
TRAF4 TNF receptor-associated factor 4 0.438282
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 0.437906
LARS leucyl-tRNA synthetase 0.437154
CST3 cystatin C 0.434148
CHN1 chimerin 1 0.434148
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35) 0.433772
GLI3 GLI family zinc finger 3 0.433772
LAMA5 laminin, alpha 5 0.42664
AGK acylglycerol kinase 0.418768
GPC5 glypican 5 0.416521
HIRA histone cell cycle regulator 0.412779
BANF1 barrier to autointegration factor 1 0.404557
SUFU suppressor of fused homolog (Drosophila) 0.398962
TYMS thymidylate synthetase 0.394863
FGF8 fibroblast growth factor 8 (androgen-induced) 0.379997
IGHE immunoglobulin heavy constant epsilon 0.37555
CST7 cystatin F (leukocystatin) 0.372958
EMX2 empty spiracles homeobox 2 0.35892
SKI SKI proto-oncogene 0.355235
FGF20 fibroblast growth factor 20 0.353027
ERCC6 excision repair cross-complementation group 6 0.348246
GLDC glycine dehydrogenase (decarboxylating) 0.346777
PEMT phosphatidylethanolamine N-methyltransferase 0.344574
RNF34 ring finger protein 34, E3 ubiquitin protein ligase 0.342739
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2 0.340906
TPI1 triosephosphate isomerase 1 0.339806
CAMP cathelicidin antimicrobial peptide 0.336876
AADACL3 arylacetamide deacetylase-like 3 0.336144
MIR10A microRNA 10a 0.335046
DVL2 dishevelled segment polarity protein 2 0.335046
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1 0.328469
PCDH11Y protocadherin 11 Y-linked 0.325552
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase) 0.319363
GCM2 glial cells missing homolog 2 (Drosophila) 0.318999
SLC39A4 solute carrier family 39 (zinc transporter), member 4 0.317182
TXN2 thioredoxin 2 0.316819
PRSS8 protease, serine, 8 0.31464
CARM1 coactivator-associated arginine methyltransferase 1 0.312827
RAET1E retinoic acid early transcript 1E 0.307395
DMRTA1 DMRT-like family A1 0.307395
STIL SCL/TAL1 interrupting locus 0.30631
PER3 period circadian clock 3 0.299812
NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5 0.295132
TCF12 transcription factor 12 0.291898
WNT3 wingless-type MMTV integration site family, member 3 0.291898
DYNLRB1 dynein, light chain, roadblock-type 1 0.290821
SMAD6 SMAD family member 6 0.285802
PCDH11X protocadherin 11 X-linked 0.28294
RERE arginine-glutamic acid dipeptide (RE) repeats 0.281868
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.281153
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1 0.280796
PRKCA protein kinase C, alpha 0.270819
MMAA methylmalonic aciduria (cobalamin deficiency) cblA type 0.267622
ATF1 activating transcription factor 1 0.266913
MST1 macrophage stimulating 1 0.266558
CFHR3 complement factor H-related 3 0.25983
PLAGL1 pleiomorphic adenoma gene-like 1 0.257005
NNMT nicotinamide N-methyltransferase 0.254183
SUOX sulfite oxidase 0.252774
IGLV3-10 immunoglobulin lambda variable 3-10 0.25207
SALL1 spalt-like transcription factor 1 0.251366
PCYT1A phosphate cytidylyltransferase 1, choline, alpha 0.251015
SLC19A1 solute carrier family 19 (folate transporter), member 1 0.246098
NR0B1 nuclear receptor subfamily 0, group B, member 1 0.244345
STAT2 signal transducer and activator of transcription 2, 113kDa 0.238403
CRLF1 cytokine receptor-like factor 1 0.23666
PDXK pyridoxal (pyridoxine, vitamin B6) kinase 0.234573
EPHB3 EPH receptor B3 0.234225
GRM4 glutamate receptor, metabotropic 4 0.22937
REST RE1-silencing transcription factor 0.229024
PAPPA pregnancy-associated plasma protein A, pappalysin 1 0.225917
TALDO1 transaldolase 1 0.219057
GJA1 gap junction protein, alpha 1, 43kDa 0.218034
FBLN5 fibulin 5 0.212945
TMEM173 transmembrane protein 173 0.209248
C19ORF48 chromosome 19 open reading frame 48 0.204923
ACE angiotensin I converting enzyme 0.204593
ANKRD11 ankyrin repeat domain 11 0.204428
PDGFC platelet derived growth factor C 0.203275
ADAR adenosine deaminase, RNA-specific 0.201635
OPRL1 opiate receptor-like 1 0.201308
TBX3 T-box 3 0.199033
PAX9 paired box 9 0.19742
NCOA1 nuclear receptor coactivator 1 0.19742
CRABP2 cellular retinoic acid binding protein 2 0.195501
PSG9 pregnancy specific beta-1-glycoprotein 9 0.192971
TDO2 tryptophan 2,3-dioxygenase 0.188326
PTK7 protein tyrosine kinase 7 (inactive) 0.18621
RPGRIP1 retinitis pigmentosa GTPase regulator interacting protein 1 0.185612
BMP2K BMP2 inducible kinase 0.183541
GRHL1 grainyhead-like 1 (Drosophila) 0.180937
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 0.180367
HLA-DQB3 major histocompatibility complex, class II, DQ beta 3 0.178682
KMT2A lysine (K)-specific methyltransferase 2A 0.174093
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5 0.172164
RBFOX3 RNA binding protein, fox-1 homolog (C. elegans) 3 0.172038
MYL2 myosin, light chain 2, regulatory, cardiac, slow 0.171286
HOXA1 homeobox A1 0.166544
KRT15 keratin 15, type I 0.166319
CD6 CD6 molecule 0.166095
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) 0.165655
UBAP1 ubiquitin associated protein 1 0.163729
HMGA2 high mobility group AT-hook 2 0.163111
SEPT5 septin 5 0.162306
CFHR1 complement factor H-related 1 0.162306
KLK4 kallikrein-related peptidase 4 0.162306
MARCKS myristoylated alanine-rich protein kinase C substrate 0.158951
BMP4 bone morphogenetic protein 4 0.157929
DCX doublecortin 0.147269
ERBB4 erb-b2 receptor tyrosine kinase 4 0.146907
ERAS ES cell expressed Ras 0.146272
COL18A1 collagen, type XVIII, alpha 1 0.144607
TF transferrin 0.144027
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain 0.143807
B3GAT1 beta-1,3-glucuronyltransferase 1 0.141999
GFAP glial fibrillary acidic protein 0.141125