spindle Gene Set

Dataset GO Cellular Component Annotations 2025
Category structural or functional annotations
Type cellular component
Description The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart. (Gene Ontology, GO_0005819)
External Link http://amigo.geneontology.org/amigo/term/GO:0005819
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Genes

228 proteins localized to the spindle cellular component from the curated GO Cellular Component Annotations 2025 dataset.

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
ADRB2 adrenoceptor beta 2, surface
AFG2A AFG2 AAA ATPase homolog A
AGBL5 ATP/GTP binding protein-like 5
ALPK3 alpha-kinase 3
ANAPC5 anaphase promoting complex subunit 5
ANAPC7 anaphase promoting complex subunit 7
ANKFN1 ankyrin-repeat and fibronectin type III domain containing 1
ANKRD53 ankyrin repeat domain 53
ANXA11 annexin A11
ARHGAP6 Rho GTPase activating protein 6
ARL3 ADP-ribosylation factor-like 3
ATAT1 alpha tubulin acetyltransferase 1
AURKA aurora kinase A
AURKB aurora kinase B
AURKC aurora kinase C
BCL2L10 BCL2-like 10 (apoptosis facilitator)
BIRC5 baculoviral IAP repeat containing 5
BOD1 biorientation of chromosomes in cell division 1
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CALM2 calmodulin 2 (phosphorylase kinase, delta)
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CAPN6 calpain 6
CBX1 chromobox homolog 1
CBX3 chromobox homolog 3
CCAR2 cell cycle and apoptosis regulator 2
CCDC117 coiled-coil domain containing 117
CCDC57 coiled-coil domain containing 57
CCDC66 coiled-coil domain containing 66
CCSAP centriole, cilia and spindle-associated protein
CD180 CD180 molecule
CDC14A cell division cycle 14A
CDC14C cell division cycle 14C
CDC16 cell division cycle 16
CDC20 cell division cycle 20
CDC27 cell division cycle 27
CDC42 cell division cycle 42
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CDK1 cyclin-dependent kinase 1
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CHAMP1 chromosome alignment maintaining phosphoprotein 1
CIAO2B cytosolic iron-sulfur assembly component 2B
CKAP2 cytoskeleton associated protein 2
CKAP2L cytoskeleton associated protein 2-like
CKAP5 cytoskeleton associated protein 5
CLASP1 cytoplasmic linker associated protein 1
CLASP2 cytoplasmic linker associated protein 2
CLTC clathrin, heavy chain (Hc)
CLTCL1 clathrin, heavy chain-like 1
CSNK1A1 casein kinase 1, alpha 1
CSNK1D casein kinase 1, delta
CSPP1 centrosome and spindle pole associated protein 1
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CUL3 cullin 3
CXCR2 chemokine (C-X-C motif) receptor 2
CYLD cylindromatosis (turban tumor syndrome)
DAPK3 death-associated protein kinase 3
DCDC1 doublecortin domain containing 1
DCTN1 dynactin 1
DCUN1D5 DCN1, defective in cullin neddylation 1, domain containing 5
DIAPH1 diaphanous-related formin 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAAF5 dynein, axonemal, assembly factor 5
DNALI1 dynein, axonemal, light intermediate chain 1
DPYSL2 dihydropyrimidinase-like 2
DR1 down-regulator of transcription 1, TBP-binding (negative cofactor 2)
DYNLL1 dynein, light chain, LC8-type 1
DZIP1L DAZ interacting zinc finger protein 1-like
ECT2 epithelial cell transforming 2
EFHC1 EF-hand domain (C-terminal) containing 1
EMD emerin
EML1 echinoderm microtubule associated protein like 1
EML2 echinoderm microtubule associated protein like 2
EML3 echinoderm microtubule associated protein like 3
EML4 echinoderm microtubule associated protein like 4
EPB41 erythrocyte membrane protein band 4.1
ERCC2 excision repair cross-complementation group 2
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
FAM110A family with sequence similarity 110, member A
FAM161A family with sequence similarity 161, member A
FBXO5 F-box protein 5
FLCN folliculin
GMNN geminin, DNA replication inhibitor
GOLGA2 golgin A2
GPX2 glutathione peroxidase 2
HASPIN histone H3 associated protein kinase
HAUS3 HAUS augmin-like complex, subunit 3
HDAC3 histone deacetylase 3
HECW2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
HEPACAM2 HEPACAM family member 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HNF4G hepatocyte nuclear factor 4, gamma
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
HSPA2 heat shock 70kDa protein 2
IFT43 intraflagellar transport 43
IFT88 intraflagellar transport 88
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
INCENP inner centromere protein antigens 135/155kDa
JTB jumping translocation breakpoint
KAT14 lysine acetyltransferase 14
KAT2A K(lysine) acetyltransferase 2A
KAT2B K(lysine) acetyltransferase 2B
KATNA1 katanin p60 (ATPase containing) subunit A 1
KATNAL1 katanin p60 subunit A-like 1
KATNAL2 katanin p60 subunit A-like 2
KATNB1 katanin p80 (WD repeat containing) subunit B 1
KATNBL1 katanin p80 subunit B-like 1
KIF11 kinesin family member 11
KIF16B kinesin family member 16B
KIF20A kinesin family member 20A
KIF22 kinesin family member 22
KIF23 kinesin family member 23
KIF2A kinesin heavy chain member 2A
KIF2B kinesin family member 2B
KIF2C kinesin family member 2C
KIF3A kinesin family member 3A
KIF3B kinesin family member 3B
KIF4A kinesin family member 4A
KIFAP3 kinesin-associated protein 3
KIFC1 kinesin family member C1
KLHL22 kelch-like family member 22
KMT5B lysine methyltransferase 5B
KNSTRN kinetochore-localized astrin/SPAG5 binding protein
LIMK2 LIM domain kinase 2
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae)
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast)
MAEA macrophage erythroblast attacher
MAP1S microtubule-associated protein 1S
MAP4 microtubule-associated protein 4
MAP7D1 MAP7 domain containing 1
MAP9 microtubule-associated protein 9
MAPK1 mitogen-activated protein kinase 1
MAPRE1 microtubule-associated protein, RP/EB family, member 1
MBIP MAP3K12 binding inhibitory protein 1
MMS19 MMS19 nucleotide excision repair homolog (S. cerevisiae)
MTCL1 microtubule crosslinking factor 1
MYF6 myogenic factor 6 (herculin)
MZT1 mitotic spindle organizing protein 1
MZT2A mitotic spindle organizing protein 2A
MZT2B mitotic spindle organizing protein 2B
NCAPG non-SMC condensin I complex, subunit G
NCOR1 nuclear receptor corepressor 1
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NGRN neugrin, neurite outgrowth associated
NIN ninein (GSK3B interacting protein)
NUDC nudC nuclear distribution protein
NUDCD2 NudC domain containing 2
NUMA1 nuclear mitotic apparatus protein 1
NUP62 nucleoporin 62kDa
NUSAP1 nucleolar and spindle associated protein 1
ODAM odontogenic, ameloblast asssociated
PARP4 poly (ADP-ribose) polymerase family, member 4
PHLPP2 PH domain and leucine rich repeat protein phosphatase 2
PIN4 peptidylprolyl cis/trans isomerase, NIMA-interacting 4
PINX1 PIN2/TERF1 interacting, telomerase inhibitor 1
PKHD1 polycystic kidney and hepatic disease 1 (autosomal recessive)
PKP4 plakophilin 4
PLK1 polo-like kinase 1
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
PRKD2 protein kinase D2
PSRC1 proline/serine-rich coiled-coil 1
PTPN7 protein tyrosine phosphatase, non-receptor type 7
PYCR3 pyrroline-5-carboxylate reductase 3
RACGAP1 Rac GTPase activating protein 1
RGS14 regulator of G-protein signaling 14
RMDN1 regulator of microtubule dynamics 1
RMDN2 regulator of microtubule dynamics 2
RMDN3 regulator of microtubule dynamics 3
RPS3 ribosomal protein S3
RTRAF RNA transcription, translation and transport factor
SAC3D1 SAC3 domain containing 1
SACK1D scaffolding CK1 anchoring protein D
SEPTIN12 septin 12
SGF29 SAGA complex associated factor 29
SHCBP1L SHC SH2-domain binding protein 1-like
SIRT2 sirtuin 2
SKA1 spindle and kinetochore associated complex subunit 1
SKA2 spindle and kinetochore associated complex subunit 2
SKA3 spindle and kinetochore associated complex subunit 3
SLC34A1 solute carrier family 34 (type II sodium/phosphate cotransporter), member 1
SPAG5 sperm associated antigen 5
SPATA5L1 spermatogenesis associated 5-like 1
SPESP1 sperm equatorial segment protein 1
SPICE1 spindle and centriole associated protein 1
SPOUT1 SPOUT domain containing methyltransferase 1
TACC3 transforming, acidic coiled-coil containing protein 3
TADA2A transcriptional adaptor 2A
TADA3 transcriptional adaptor 3
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TBCK TBC1 domain containing kinase
TBL1X transducin (beta)-like 1X-linked
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TERF1 telomeric repeat binding factor (NIMA-interacting) 1
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)
TMEM9 transmembrane protein 9
TPPP tubulin polymerization promoting protein
TPR translocated promoter region, nuclear basket protein
TPX2 TPX2, microtubule-associated
TRAPPC14 trafficking protein particle complex subunit 14
TRAT1 T cell receptor associated transmembrane adaptor 1
TTK TTK protein kinase
TTL tubulin tyrosine ligase
TUBB tubulin, beta class I
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
TUBB3 tubulin, beta 3 class III
TUBB4A tubulin, beta 4A class IVa
TUBB4B tubulin, beta 4B class IVb
TUBB6 tubulin, beta 6 class V
TUBB8 tubulin, beta 8 class VIII
TUBB8B tubulin beta 8B
TUBG1 tubulin, gamma 1
TUBG2 tubulin, gamma 2
TUBGCP3 tubulin, gamma complex associated protein 3
UHRF1 ubiquitin-like with PHD and ring finger domains 1
USP44 ubiquitin specific peptidase 44
WAPL WAPL cohesin release factor
WDR5 WD repeat domain 5
WNK1 WNK lysine deficient protein kinase 1
YEATS2 YEATS domain containing 2
ZNF367 zinc finger protein 367
ZZZ3 zinc finger, ZZ-type containing 3