spiradoline-3818 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the spiradoline-3818 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4
ACACB acetyl-CoA carboxylase beta
ACPP acid phosphatase, prostate
ACVRL1 activin A receptor type II-like 1
AK5 adenylate kinase 5
AKAP8L A kinase (PRKA) anchor protein 8-like
AKT2 v-akt murine thymoma viral oncogene homolog 2
ANGPTL2 angiopoietin-like 2
AQP3 aquaporin 3 (Gill blood group)
ATF5 activating transcription factor 5
B9D2 B9 protein domain 2
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
C19ORF57 chromosome 19 open reading frame 57
C7ORF69 chromosome 7 open reading frame 69
CADM4 cell adhesion molecule 4
CCL27 chemokine (C-C motif) ligand 27
CD1E CD1e molecule
CDK13 cyclin-dependent kinase 13
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CFAP70 cilia and flagella associated protein 70
CLCN7 chloride channel, voltage-sensitive 7
CNGA1 cyclic nucleotide gated channel alpha 1
CNN1 calponin 1, basic, smooth muscle
COL6A1 collagen, type VI, alpha 1
CREBZF CREB/ATF bZIP transcription factor
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
DEFA4 defensin, alpha 4, corticostatin
DHX34 DEAH (Asp-Glu-Ala-His) box polypeptide 34
DKK3 dickkopf WNT signaling pathway inhibitor 3
DOCK9 dedicator of cytokinesis 9
DRICH1 aspartate-rich 1
EDN3 endothelin 3
ELF5 E74-like factor 5 (ets domain transcription factor)
ETV5 ets variant 5
FAM135A family with sequence similarity 135, member A
FAM162A family with sequence similarity 162, member A
FGF6 fibroblast growth factor 6
FLJ22184
FRMD1 FERM domain containing 1
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GABARAPL3 GABA(A) receptors associated protein like 3, pseudogene
GPR137 G protein-coupled receptor 137
HLA-DOA major histocompatibility complex, class II, DO alpha
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HNF4A hepatocyte nuclear factor 4, alpha
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
HPS1 Hermansky-Pudlak syndrome 1
HRG histidine-rich glycoprotein
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
IFITM1 interferon induced transmembrane protein 1
KIFC1 kinesin family member C1
KLK12 kallikrein-related peptidase 12
LDB3 LIM domain binding 3
LDLRAD4 low density lipoprotein receptor class A domain containing 4
LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2
MGAT3 mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
MMP14 matrix metallopeptidase 14 (membrane-inserted)
N4BP2L1 NEDD4 binding protein 2-like 1
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa
NIPAL3 NIPA-like domain containing 3
NPHP1 nephronophthisis 1 (juvenile)
NPTX1 neuronal pentraxin I
NRP2 neuropilin 2
OMD osteomodulin
OPCML opioid binding protein/cell adhesion molecule-like
OR2B6 olfactory receptor, family 2, subfamily B, member 6
P2RY1 purinergic receptor P2Y, G-protein coupled, 1
PAWR PRKC, apoptosis, WT1, regulator
PCDHGA11 protocadherin gamma subfamily A, 11
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PDE7B phosphodiesterase 7B
PGM5 phosphoglucomutase 5
PHLPP2 PH domain and leucine rich repeat protein phosphatase 2
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4
PLCH2 phospholipase C, eta 2
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
RAG1 recombination activating gene 1
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RETN resistin
RNF126P1 ring finger protein 126 pseudogene 1
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
SAMD4A sterile alpha motif domain containing 4A
SCAND2P SCAN domain containing 2 pseudogene
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SMG7 SMG7 nonsense mediated mRNA decay factor
SSTR2 somatostatin receptor 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFR2 transferrin receptor 2
TMPRSS11D transmembrane protease, serine 11D
TP53I11 tumor protein p53 inducible protein 11
TP73-AS1 TP73 antisense RNA 1
TRIM10 tripartite motif containing 10
TTC9 tetratricopeptide repeat domain 9
TTLL1 tubulin tyrosine ligase-like family member 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UNC5C unc-5 homolog C (C. elegans)
YIF1B Yip1 interacting factor homolog B (S. cerevisiae)

decreased expression

Symbol Name
A1CF APOBEC1 complementation factor
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
AKAP5 A kinase (PRKA) anchor protein 5
ALPK1 alpha-kinase 1
AMDHD2 amidohydrolase domain containing 2
AMT aminomethyltransferase
ANKH ANKH inorganic pyrophosphate transport regulator
APOBEC2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
ARL14 ADP-ribosylation factor-like 14
ARMCX4 armadillo repeat containing, X-linked 4
ASPHD1 aspartate beta-hydroxylase domain containing 1
BEGAIN brain-enriched guanylate kinase-associated
C16ORF45 chromosome 16 open reading frame 45
C1ORF105 chromosome 1 open reading frame 105
CBR4 carbonyl reductase 4
CBS cystathionine-beta-synthase
CD82 CD82 molecule
CISH cytokine inducible SH2-containing protein
CLSPN claspin
COPZ2 coatomer protein complex, subunit zeta 2
DAGLA diacylglycerol lipase, alpha
DENND4A DENN/MADD domain containing 4A
DGKE diacylglycerol kinase, epsilon 64kDa
DHRS9 dehydrogenase/reductase (SDR family) member 9
DNAL4 dynein, axonemal, light chain 4
DPF3 D4, zinc and double PHD fingers, family 3
EGF epidermal growth factor
EML4 echinoderm microtubule associated protein like 4
ERN2 endoplasmic reticulum to nucleus signaling 2
ERO1LB ERO1-like beta (S. cerevisiae)
FKBP5 FK506 binding protein 5
FKRP fukutin related protein
FLJ21369 uncharacterized protein FLJ21369
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GAN gigaxonin
GK3P glycerol kinase 3 pseudogene
GMPR guanosine monophosphate reductase
GNG3 guanine nucleotide binding protein (G protein), gamma 3
GPNMB glycoprotein (transmembrane) nmb
GREB1L growth regulation by estrogen in breast cancer-like
GSTCD glutathione S-transferase, C-terminal domain containing
HHAT hedgehog acyltransferase
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HOXB2 homeobox B2
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8
IL32 interleukin 32
ITK IL2-inducible T-cell kinase
KCNMB4 potassium channel subfamily M regulatory beta subunit 4
KDM8 lysine (K)-specific demethylase 8
KLHL25 kelch-like family member 25
LIMD2 LIM domain containing 2
LINC00597 long intergenic non-protein coding RNA 597
LOC202181 SUMO-interacting motifs containing 1 pseudogene
MAGEA12 melanoma antigen family A12
MAGEA5 melanoma antigen family A5
MAGEB2 melanoma antigen family B2
MAL mal, T-cell differentiation protein
MEF2D myocyte enhancer factor 2D
MEGF8 multiple EGF-like-domains 8
MRAS muscle RAS oncogene homolog
NCALD neurocalcin delta
NDNF neuron-derived neurotrophic factor
NEO1 neogenin 1
NPY1R neuropeptide Y receptor Y1
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
OSMR oncostatin M receptor
PIP prolactin-induced protein
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
PTPRS protein tyrosine phosphatase, receptor type, S
RIN1 Ras and Rab interactor 1
RNF122 ring finger protein 122
RUNX1-IT1 RUNX1 intronic transcript 1
SAYSD1 SAYSVFN motif domain containing 1
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
SLC16A6 solute carrier family 16, member 6
SLC35F5 solute carrier family 35, member F5
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SPANXC SPANX family, member C
ST7L suppression of tumorigenicity 7 like
TAGLN3 transgelin 3
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TCTN2 tectonic family member 2
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TMEM74B transmembrane protein 74B
TTC30A tetratricopeptide repeat domain 30A
USP6NL USP6 N-terminal like
VASP vasodilator-stimulated phosphoprotein
WDR25 WD repeat domain 25
XDH xanthine dehydrogenase
ZNF225 zinc finger protein 225
ZNF268 zinc finger protein 268
ZNF573 zinc finger protein 573
ZNF749 zinc finger protein 749
ZNF76 zinc finger protein 76
ZXDB zinc finger, X-linked, duplicated B