| Dataset | CMAP Signatures of Differentially Expressed Genes for Small Molecules |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis) |
| Similar Terms | |
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200 genes differentially expressed following the spironolactone-2064 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
| Symbol | Name |
|---|---|
| ACACB | acetyl-CoA carboxylase beta |
| ACOT11 | acyl-CoA thioesterase 11 |
| AK1 | adenylate kinase 1 |
| ALDH4A1 | aldehyde dehydrogenase 4 family, member A1 |
| AQR | aquarius intron-binding spliceosomal factor |
| ATP7A | ATPase, Cu++ transporting, alpha polypeptide |
| BCL2L2 | BCL2-like 2 |
| BICD1 | bicaudal D homolog 1 (Drosophila) |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) |
| BTRC | beta-transducin repeat containing E3 ubiquitin protein ligase |
| C11ORF30 | chromosome 11 open reading frame 30 |
| C17ORF80 | chromosome 17 open reading frame 80 |
| C5ORF45 | chromosome 5 open reading frame 45 |
| CD40 | CD40 molecule, TNF receptor superfamily member 5 |
| CD6 | CD6 molecule |
| CDKL3 | cyclin-dependent kinase-like 3 |
| CEP68 | centrosomal protein 68kDa |
| CLN8 | ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation) |
| CREB1 | cAMP responsive element binding protein 1 |
| CTSZ | cathepsin Z |
| DAPK3 | death-associated protein kinase 3 |
| DNAJA4 | DnaJ (Hsp40) homolog, subfamily A, member 4 |
| DTX2 | deltex 2, E3 ubiquitin ligase |
| EFNA3 | ephrin-A3 |
| EHD3 | EH-domain containing 3 |
| EPHA1 | EPH receptor A1 |
| ETV5 | ets variant 5 |
| EXD3 | exonuclease 3'-5' domain containing 3 |
| EYA4 | EYA transcriptional coactivator and phosphatase 4 |
| FABP4 | fatty acid binding protein 4, adipocyte |
| FMO5 | flavin containing monooxygenase 5 |
| GATA3 | GATA binding protein 3 |
| GIF | gastric intrinsic factor (vitamin B synthesis) |
| GPR4 | G protein-coupled receptor 4 |
| HCFC1R1 | host cell factor C1 regulator 1 (XPO1 dependent) |
| HIRIP3 | HIRA interacting protein 3 |
| IFI6 | interferon, alpha-inducible protein 6 |
| INPP4A | inositol polyphosphate-4-phosphatase, type I, 107kDa |
| ITGA2B | integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) |
| ITGB5 | integrin, beta 5 |
| JRK | Jrk homolog (mouse) |
| KAT6B | K(lysine) acetyltransferase 6B |
| KDM6A | lysine (K)-specific demethylase 6A |
| KIAA0930 | KIAA0930 |
| KRT16 | keratin 16, type I |
| LIG3 | ligase III, DNA, ATP-dependent |
| LOC730101 | uncharacterized LOC730101 |
| LRP5L | low density lipoprotein receptor-related protein 5-like |
| LRP6 | low density lipoprotein receptor-related protein 6 |
| MED28 | mediator complex subunit 28 |
| MFSD6 | major facilitator superfamily domain containing 6 |
| MID1 | midline 1 |
| MIIP | migration and invasion inhibitory protein |
| MTHFD2L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like |
| MXD3 | MAX dimerization protein 3 |
| NAB2 | NGFI-A binding protein 2 (EGR1 binding protein 2) |
| NADK | NAD kinase |
| OSBPL10 | oxysterol binding protein-like 10 |
| PCM1 | pericentriolar material 1 |
| PEX26 | peroxisomal biogenesis factor 26 |
| PHC1 | polyhomeotic homolog 1 (Drosophila) |
| PI4K2A | phosphatidylinositol 4-kinase type 2 alpha |
| PIDD1 | p53-induced death domain protein 1 |
| PLXND1 | plexin D1 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa |
| R3HDM4 | R3H domain containing 4 |
| RAPGEF5 | Rap guanine nucleotide exchange factor (GEF) 5 |
| RBPMS | RNA binding protein with multiple splicing |
| REL | v-rel avian reticuloendotheliosis viral oncogene homolog |
| RPL10 | ribosomal protein L10 |
| RPL23AP32 | ribosomal protein L23a pseudogene 32 |
| RUNX1 | runt-related transcription factor 1 |
| SEMA3F | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F |
| SEPP1 | selenoprotein P, plasma, 1 |
| SLC46A3 | solute carrier family 46, member 3 |
| SMARCD3 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase |
| SMG7 | SMG7 nonsense mediated mRNA decay factor |
| SPRED2 | sprouty-related, EVH1 domain containing 2 |
| STS | steroid sulfatase (microsomal), isozyme S |
| SUGP1 | SURP and G patch domain containing 1 |
| SULT1A2 | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2 |
| SYT17 | synaptotagmin XVII |
| TEX261 | testis expressed 261 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 |
| TM4SF1 | transmembrane 4 L six family member 1 |
| TOMM40 | translocase of outer mitochondrial membrane 40 homolog (yeast) |
| TPMT | thiopurine S-methyltransferase |
| TRIOBP | TRIO and F-actin binding protein |
| TTC38 | tetratricopeptide repeat domain 38 |
| TUBG2 | tubulin, gamma 2 |
| USP27X | ubiquitin specific peptidase 27, X-linked |
| WDFY3 | WD repeat and FYVE domain containing 3 |
| WHSC1 | Wolf-Hirschhorn syndrome candidate 1 |
| ZBTB7A | zinc finger and BTB domain containing 7A |
| ZFP30 | ZFP30 zinc finger protein |
| ZNF34 | zinc finger protein 34 |
| ZNF43 | zinc finger protein 43 |
| ZNF710 | zinc finger protein 710 |
| ZNF770 | zinc finger protein 770 |
| Symbol | Name |
|---|---|
| ABCA7 | ATP-binding cassette, sub-family A (ABC1), member 7 |
| ACOX2 | acyl-CoA oxidase 2, branched chain |
| AFAP1 | actin filament associated protein 1 |
| APOLD1 | apolipoprotein L domain containing 1 |
| ARHGAP10 | Rho GTPase activating protein 10 |
| ARHGEF1 | Rho guanine nucleotide exchange factor (GEF) 1 |
| ARHGEF10L | Rho guanine nucleotide exchange factor (GEF) 10-like |
| ARL14 | ADP-ribosylation factor-like 14 |
| ARRB2 | arrestin, beta 2 |
| BAHD1 | bromo adjacent homology domain containing 1 |
| BMP15 | bone morphogenetic protein 15 |
| BOLA1 | bolA family member 1 |
| C16ORF59 | chromosome 16 open reading frame 59 |
| C17ORF70 | chromosome 17 open reading frame 70 |
| C19ORF40 | chromosome 19 open reading frame 40 |
| C1ORF56 | chromosome 1 open reading frame 56 |
| CACNG1 | calcium channel, voltage-dependent, gamma subunit 1 |
| CAMTA2 | calmodulin binding transcription activator 2 |
| CAPN15 | calpain 15 |
| CDK5RAP2 | CDK5 regulatory subunit associated protein 2 |
| CLASRP | CLK4-associating serine/arginine rich protein |
| CLCN5 | chloride channel, voltage-sensitive 5 |
| CNGB3 | cyclic nucleotide gated channel beta 3 |
| CPVL | carboxypeptidase, vitellogenic-like |
| CST4 | cystatin S |
| CXCL2 | chemokine (C-X-C motif) ligand 2 |
| DNAJC28 | DnaJ (Hsp40) homolog, subfamily C, member 28 |
| DPM2 | dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit |
| DTWD1 | DTW domain containing 1 |
| EDC3 | enhancer of mRNA decapping 3 |
| FAM102A | family with sequence similarity 102, member A |
| FAM155A | family with sequence similarity 155, member A |
| FAM50B | family with sequence similarity 50, member B |
| FBXO2 | F-box protein 2 |
| FICD | FIC domain containing |
| FKBPL | FK506 binding protein like |
| GALT | galactose-1-phosphate uridylyltransferase |
| GPR1 | G protein-coupled receptor 1 |
| GUCY1A3 | guanylate cyclase 1, soluble, alpha 3 |
| GUSBP3 | glucuronidase, beta pseudogene 3 |
| HDAC7 | histone deacetylase 7 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 |
| HINFP | histone H4 transcription factor |
| HIST1H2BJ | histone cluster 1, H2bj |
| IFNAR1 | interferon (alpha, beta and omega) receptor 1 |
| IL24 | interleukin 24 |
| IRF1 | interferon regulatory factor 1 |
| IRF2BP1 | interferon regulatory factor 2 binding protein 1 |
| KDM5C | lysine (K)-specific demethylase 5C |
| KIAA1549L | KIAA1549-like |
| KLC2 | kinesin light chain 2 |
| KLF2 | Kruppel-like factor 2 |
| KPTN | kaptin (actin binding protein) |
| KRT4 | keratin 4, type II |
| LOC100272216 | uncharacterized LOC100272216 |
| LRRC6 | leucine rich repeat containing 6 |
| MAFG | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G |
| MNX1 | motor neuron and pancreas homeobox 1 |
| MUC3B | mucin 3B, cell surface associated |
| MXRA8 | matrix-remodelling associated 8 |
| NACA2 | nascent polypeptide-associated complex alpha subunit 2 |
| NAGPA | N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase |
| NCS1 | neuronal calcium sensor 1 |
| NDE1 | nudE neurodevelopment protein 1 |
| NECAB3 | N-terminal EF-hand calcium binding protein 3 |
| NME6 | NME/NM23 nucleoside diphosphate kinase 6 |
| NPY1R | neuropeptide Y receptor Y1 |
| P3H4 | prolyl 3-hydroxylase family member 4 (non-enzymatic) |
| PACSIN3 | protein kinase C and casein kinase substrate in neurons 3 |
| PGS1 | phosphatidylglycerophosphate synthase 1 |
| PIM1 | Pim-1 proto-oncogene, serine/threonine kinase |
| PISD | phosphatidylserine decarboxylase |
| PLEKHM2 | pleckstrin homology domain containing, family M (with RUN domain) member 2 |
| RAB3A | RAB3A, member RAS oncogene family |
| RARS | arginyl-tRNA synthetase |
| RBM38 | RNA binding motif protein 38 |
| RUFY2 | RUN and FYVE domain containing 2 |
| RUNX1-IT1 | RUNX1 intronic transcript 1 |
| SDC3 | syndecan 3 |
| SETD6 | SET domain containing 6 |
| SGTA | small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha |
| SH2B2 | SH2B adaptor protein 2 |
| SLC25A23 | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23 |
| SLC35C2 | solute carrier family 35 (GDP-fucose transporter), member C2 |
| SLC35F6 | solute carrier family 35, member F6 |
| SMEK2 | SMEK homolog 2, suppressor of mek1 (Dictyostelium) |
| ST3GAL5 | ST3 beta-galactoside alpha-2,3-sialyltransferase 5 |
| ST6GALNAC5 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 |
| SUGCT | succinyl-CoA:glutarate-CoA transferase |
| TAB1 | TGF-beta activated kinase 1/MAP3K7 binding protein 1 |
| TINAGL1 | tubulointerstitial nephritis antigen-like 1 |
| TKFC | triokinase/FMN cyclase |
| TMEM160 | transmembrane protein 160 |
| TRAF6 | TNF receptor-associated factor 6, E3 ubiquitin protein ligase |
| TRPM4 | transient receptor potential cation channel, subfamily M, member 4 |
| UBQLN4 | ubiquilin 4 |
| UBTD1 | ubiquitin domain containing 1 |
| USP5 | ubiquitin specific peptidase 5 (isopeptidase T) |
| WARS2 | tryptophanyl tRNA synthetase 2, mitochondrial |
| WDR33 | WD repeat domain 33 |
