spondyloarthropathy Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description Heterogeneous group of arthritic diseases sharing clinical and radiologic features. They are associated with the HLA-B27 ANTIGEN and some with a triggering infection. Most involve the axial joints in the SPINE, particularly the SACROILIAC JOINT, but can also involve asymmetric peripheral joints. Subsets include ANKYLOSING SPONDYLITIS; REACTIVE ARTHRITIS; PSORIATIC ARTHRITIS; and others. (Experimental Factor Ontology, EFO_0000706)
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Genes

78 genes co-occuring with the disease spondyloarthropathy in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
MRAP melanocortin 2 receptor accessory protein 2.3484
PHB2 prohibitin 2 1.75187
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 1.37338
CRP C-reactive protein, pentraxin-related 1.35768
CREG1 cellular repressor of E1A-stimulated genes 1 1.34635
B2M beta-2-microglobulin 1.24254
HLA-C major histocompatibility complex, class I, C 1.14348
ACAN aggrecan 1.05177
ARG2 arginase 2 0.873281
TNF tumor necrosis factor 0.849945
ERAP1 endoplasmic reticulum aminopeptidase 1 0.751678
CYP26C1 cytochrome P450, family 26, subfamily C, polypeptide 1 0.60147
HLA-A major histocompatibility complex, class I, A 0.594454
CD79A CD79a molecule, immunoglobulin-associated alpha 0.592895
DYNLT1 dynein, light chain, Tctex-type 1 0.583552
CD163 CD163 molecule 0.582384
HLA-B major histocompatibility complex, class I, B 0.565277
CD4 CD4 molecule 0.538506
CD80 CD80 molecule 0.517265
HGD homogentisate 1,2-dioxygenase 0.513802
MEFV Mediterranean fever 0.491597
HLA-E major histocompatibility complex, class I, E 0.490835
USP8 ubiquitin specific peptidase 8 0.480945
OR2Y1 olfactory receptor, family 2, subfamily Y, member 1 0.479427
MSLNL mesothelin-like 0.469954
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.461261
KREMEN1 kringle containing transmembrane protein 1 0.459373
COL6A1 collagen, type VI, alpha 1 0.457109
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 0.448064
ANO6 anoctamin 6 0.445429
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) 0.433021
EMC3 ER membrane protein complex subunit 3 0.423265
HIP1R huntingtin interacting protein 1 related 0.386308
ERAP2 endoplasmic reticulum aminopeptidase 2 0.365193
NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5 0.364454
VCAN versican 0.364085
PTDSS1 phosphatidylserine synthase 1 0.358183
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 0.341639
MMP3 matrix metallopeptidase 3 0.331025
PTH parathyroid hormone 0.311014
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8 0.303781
NLRP2 NLR family, pyrin domain containing 2 0.294772
COL2A1 collagen, type II, alpha 1 0.289744
AGK acylglycerol kinase 0.28294
CD68 CD68 molecule 0.280439
IL10 interleukin 10 0.266203
SCNN1D sodium channel, non voltage gated 1 delta subunit 0.257711
ANTXR2 anthrax toxin receptor 2 0.256299
MNDA myeloid cell nuclear differentiation antigen 0.243645
HAPLN1 hyaluronan and proteoglycan link protein 1 0.226262
RAN RAN, member RAS oncogene family 0.225917
SUN3 Sad1 and UNC84 domain containing 3 0.222822
SPG20 spastic paraplegia 20 (Troyer syndrome) 0.209918
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 0.205916
CD83 CD83 molecule 0.199681
ALPL alkaline phosphatase, liver/bone/kidney 0.190786
IL23R interleukin 23 receptor 0.186811
IFNG interferon, gamma 0.184128
HSPA1L heat shock 70kDa protein 1-like 0.179802
IGBP1 immunoglobulin (CD79A) binding protein 1 0.141918
MATN1 matrilin 1, cartilage matrix protein 0.141892
SFTPA1 surfactant protein A1 0.141782
SOST sclerostin 0.141467
CARD9 caspase recruitment domain family, member 9 0.141402
TNFRSF4 tumor necrosis factor receptor superfamily, member 4 0.141217
IL1R2 interleukin 1 receptor, type II 0.140992
MICA MHC class I polypeptide-related sequence A 0.140601
SCG5 secretogranin V 0.140195
YME1L1 YME1-like 1 ATPase 0.139774
MICB MHC class I polypeptide-related sequence B 0.139339
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit 0.138243
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.137549
NELFCD negative elongation factor complex member C/D 0.137371
TP73 tumor protein p73 0.136907
FAM195A family with sequence similarity 195, member A 0.136631
CCL8 chemokine (C-C motif) ligand 8 0.135257
TCHH trichohyalin 0.134895
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5 0.134708