spondyloarthropathy Gene Set

Dataset	GeneRIF Biological Term Annotations
Category	structural or functional annotations
Type	biological term
Description	Heterogeneous group of arthritic diseases sharing clinical and radiologic features. They are associated with the HLA-B27 ANTIGEN and some with a triggering infection. Most involve the axial joints in the SPINE, particularly the SACROILIAC JOINT, but can also involve asymmetric peripheral joints. Subsets include ANKYLOSING SPONDYLITIS; REACTIVE ARTHRITIS; PSORIATIC ARTHRITIS; and others. (Experimental Factor Ontology, EFO_0000706)
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Genes

16 genes co-occuring with the biological term spondyloarthropathy in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol	Name
CCL2	chemokine (C-C motif) ligand 2
FAS	Fas cell surface death receptor
HLA-B	major histocompatibility complex, class I, B
ICOS	inducible T-cell co-stimulator
IL12B	interleukin 12B
IL17A	interleukin 17A
IL1B	interleukin 1, beta
IL20	interleukin 20
IL21	interleukin 21
IL24	interleukin 24
IL6	interleukin 6
MEFV	Mediterranean fever
MMP3	matrix metallopeptidase 3
NLRP2	NLR family, pyrin domain containing 2
SLPI	secretory leukocyte peptidase inhibitor
SPARC	secreted protein, acidic, cysteine-rich (osteonectin)