spontaneous chromosome breakage Gene Set
Genes
22 gene mutations causing the spontaneous chromosome breakage phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.
| Symbol |
Name |
|
ATM
|
ATM serine/threonine kinase
|
|
ATR
|
ATR serine/threonine kinase
|
|
COPS5
|
COP9 signalosome subunit 5
|
|
FANCA
|
Fanconi anemia, complementation group A
|
|
FANCC
|
Fanconi anemia, complementation group C
|
|
FANCG
|
Fanconi anemia, complementation group G
|
|
LIG4
|
ligase IV, DNA, ATP-dependent
|
|
MCM4
|
minichromosome maintenance complex component 4
|
|
MCM8
|
minichromosome maintenance complex component 8
|
|
MCM9
|
minichromosome maintenance complex component 9
|
|
MDC1
|
mediator of DNA-damage checkpoint 1
|
|
MRE11A
|
MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
|
|
MYC
|
v-myc avian myelocytomatosis viral oncogene homolog
|
|
NHEJ1
|
nonhomologous end-joining factor 1
|
|
RAG1
|
recombination activating gene 1
|
|
RECQL
|
RecQ helicase-like
|
|
REV3L
|
REV3-like, polymerase (DNA directed), zeta, catalytic subunit
|
|
RNF8
|
ring finger protein 8, E3 ubiquitin protein ligase
|
|
SIRT6
|
sirtuin 6
|
|
TP53
|
tumor protein p53
|
|
TP53BP1
|
tumor protein p53 binding protein 1
|
|
XRCC4
|
X-ray repair complementing defective repair in Chinese hamster cells 4
|
