spontaneous Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
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Genes

424 genes co-occuring with the biological term spontaneous in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
A2M alpha-2-macroglobulin
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8
ACE angiotensin I converting enzyme
ACP1 acid phosphatase 1, soluble
ACP5 acid phosphatase 5, tartrate resistant
ACTA2 actin, alpha 2, smooth muscle, aorta
ACVR1 activin A receptor, type I
ADA adenosine deaminase
ADAM12 ADAM metallopeptidase domain 12
ADM adrenomedullin
ADORA2A adenosine A2a receptor
ADRA2B adrenoceptor alpha 2B
AGRN agrin
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
AICDA activation-induced cytidine deaminase
AKR1D1 aldo-keto reductase family 1, member D1
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ALPP alkaline phosphatase, placental
AMH anti-Mullerian hormone
AMN amnion associated transmembrane protein
ANGPTL4 angiopoietin-like 4
ANXA5 annexin A5
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APLN apelin
APOC1 apolipoprotein C-I
APOE apolipoprotein E
APP amyloid beta (A4) precursor protein
AQP9 aquaporin 9
AR androgen receptor
ASIC1 acid sensing (proton gated) ion channel 1
ASPH aspartate beta-hydroxylase
ATF4 activating transcription factor 4
BAG3 BCL2-associated athanogene 3
BAX BCL2-associated X protein
BCHE butyrylcholinesterase
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
BDNF brain-derived neurotrophic factor
BIRC2 baculoviral IAP repeat containing 2
BIRC5 baculoviral IAP repeat containing 5
BLVRA biliverdin reductase A
BMP2 bone morphogenetic protein 2
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C5 complement component 5
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CARD11 caspase recruitment domain family, member 11
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP10 caspase 10, apoptosis-related cysteine peptidase
CASP2 caspase 2, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CBX3 chromobox homolog 3
CCL16 chemokine (C-C motif) ligand 16
CCL2 chemokine (C-C motif) ligand 2
CCL5 chemokine (C-C motif) ligand 5
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD160 CD160 molecule
CD1B CD1b molecule
CD1C CD1c molecule
CD1D CD1d molecule
CD1E CD1e molecule
CD24 CD24 molecule
CD27 CD27 molecule
CD320 CD320 molecule
CD44 CD44 molecule (Indian blood group)
CD46 CD46 molecule, complement regulatory protein
CD47 CD47 molecule
CDK4 cyclin-dependent kinase 4
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CFB complement factor B
CFH complement factor H
CKM creatine kinase, muscle
CLCA1 chloride channel accessory 1
CNR1 cannabinoid receptor 1 (brain)
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL5A1 collagen, type V, alpha 1
COL5A2 collagen, type V, alpha 2
COMT catechol-O-methyltransferase
CPB2 carboxypeptidase B2 (plasma)
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CRP C-reactive protein, pentraxin-related
CSF3 colony stimulating factor 3 (granulocyte)
CST3 cystatin C
CTAG1B cancer/testis antigen 1B
CTAG2 cancer/testis antigen 2
CTSB cathepsin B
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR2 chemokine (C-X-C motif) receptor 2
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DICER1 dicer 1, ribonuclease type III
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLK1 delta-like 1 homolog (Drosophila)
DMD dystrophin
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DRD2 dopamine receptor D2
EDN1 endothelin 1
EGFR epidermal growth factor receptor
ELANE elastase, neutrophil expressed
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
F11 coagulation factor XI
F13A1 coagulation factor XIII, A1 polypeptide
F2R coagulation factor II (thrombin) receptor
F3 coagulation factor III (thromboplastin, tissue factor)
F5 coagulation factor V (proaccelerin, labile factor)
F9 coagulation factor IX
FAAH fatty acid amide hydrolase
FANCC Fanconi anemia, complementation group C
FANCD2 Fanconi anemia, complementation group D2
FAS Fas cell surface death receptor
FBLN5 fibulin 5
FBN1 fibrillin 1
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
FHIT fragile histidine triad
FKBP1B FK506 binding protein 1B, 12.6 kDa
FLCN folliculin
FLT1 fms-related tyrosine kinase 1
FN1 fibronectin 1
FOXO3 forkhead box O3
FOXP3 forkhead box P3
FSHR follicle stimulating hormone receptor
FTMT ferritin mitochondrial
FUT2 fucosyltransferase 2 (secretor status included)
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GAS1 growth arrest-specific 1
GCG glucagon
GCK glucokinase (hexokinase 4)
GEM GTP binding protein overexpressed in skeletal muscle
GH1 growth hormone 1
GHR growth hormone receptor
GJB2 gap junction protein, beta 2, 26kDa
GJB6 gap junction protein, beta 6, 30kDa
GNLY granulysin
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
GREM1 gremlin 1, DAN family BMP antagonist
GRM2 glutamate receptor, metabotropic 2
GSTA1 glutathione S-transferase alpha 1
GSTM1 glutathione S-transferase mu 1
GSTT1 glutathione S-transferase theta 1
H19 H19, imprinted maternally expressed transcript (non-protein coding)
HAS2 hyaluronan synthase 2
HAVCR2 hepatitis A virus cellular receptor 2
HBB hemoglobin, beta
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1
HCN2 hyperpolarization activated cyclic nucleotide gated potassium channel 2
HCP5 HLA complex P5 (non-protein coding)
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-DOA major histocompatibility complex, class II, DO alpha
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLA-E major histocompatibility complex, class I, E
HLA-G major histocompatibility complex, class I, G
HMGA2 high mobility group AT-hook 2
HMOX1 heme oxygenase 1
HOXC9 homeobox C9
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic
HYAL2 hyaluronoglucosaminidase 2
ICAM1 intercellular adhesion molecule 1
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDO1 indoleamine 2,3-dioxygenase 1
IFNG interferon, gamma
IFNL3 interferon, lambda 3
IFNL4 interferon, lambda 4 (gene/pseudogene)
IFNLR1 interferon, lambda receptor 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF2 insulin-like growth factor 2
IGF2R insulin-like growth factor 2 receptor
IGFBP1 insulin-like growth factor binding protein 1
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IL10 interleukin 10
IL11 interleukin 11
IL12B interleukin 12B
IL15 interleukin 15
IL16 interleukin 16
IL17A interleukin 17A
IL18 interleukin 18
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL1RN interleukin 1 receptor antagonist
IL2 interleukin 2
IL21 interleukin 21
IL23A interleukin 23, alpha subunit p19
IL31 interleukin 31
IL33 interleukin 33
IL4 interleukin 4
IL4R interleukin 4 receptor
IL6 interleukin 6
IL6R interleukin 6 receptor
IL6ST interleukin 6 signal transducer
IL7 interleukin 7
IL9 interleukin 9
IL9R interleukin 9 receptor
IPO7 importin 7
IPO8 importin 8
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGA6 integrin, alpha 6
ITGA9 integrin, alpha 9
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit)
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITPKB inositol-trisphosphate 3-kinase B
JAG2 jagged 2
JAK2 Janus kinase 2
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5
KCNH3 potassium channel, voltage gated eag related subfamily H, member 3
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KDR kinase insert domain receptor
KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
KIR2DL2 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2
KISS1 KiSS-1 metastasis-suppressor
KISS1R KISS1 receptor
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KITLG KIT ligand
KLRD1 killer cell lectin-like receptor subfamily D, member 1
KLRK1 killer cell lectin-like receptor subfamily K, member 1
KRT14 keratin 14, type I
L1TD1 LINE-1 type transposase domain containing 1
LAPTM5 lysosomal protein transmembrane 5
LEP leptin
LIF leukemia inhibitory factor
LNPEP leucyl/cystinyl aminopeptidase
LOXL1 lysyl oxidase-like 1
LPL lipoprotein lipase
LRRK2 leucine-rich repeat kinase 2
LTA lymphotoxin alpha
LZTS2 leucine zipper, putative tumor suppressor 2
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MADD MAP-kinase activating death domain
MAGEA1 melanoma antigen family A1
MAGEA3 melanoma antigen family A3
MB21D1 Mab-21 domain containing 1
MBL2 mannose-binding lectin (protein C) 2, soluble
MECP2 methyl CpG binding protein 2
MEG3 maternally expressed 3 (non-protein coding)
MEST mesoderm specific transcript
MET MET proto-oncogene, receptor tyrosine kinase
MICA MHC class I polypeptide-related sequence A
MICB MHC class I polypeptide-related sequence B
MIR133A1 microRNA 133a-1
MIR146A microRNA 146a
MIR149 microRNA 149
MIR196A2 microRNA 196a-2
MIR371A microRNA 371a
MIR372 microRNA 372
MIR373 microRNA 373
MIR499A microRNA 499a
MMP1 matrix metallopeptidase 1
MMP2 matrix metallopeptidase 2
MMP9 matrix metallopeptidase 9
MPL MPL proto-oncogene, thrombopoietin receptor
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTNR1A melatonin receptor 1A
MTNR1B melatonin receptor 1B
MUC1 mucin 1, cell surface associated
MUS81 MUS81 structure-specific endonuclease subunit
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
MYD88 myeloid differentiation primary response 88
NAMPT nicotinamide phosphoribosyltransferase
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
NCR1 natural cytotoxicity triggering receptor 1
NCR2 natural cytotoxicity triggering receptor 2
NCR3 natural cytotoxicity triggering receptor 3
NES nestin
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NGF nerve growth factor (beta polypeptide)
NGFR nerve growth factor receptor
NHEJ1 nonhomologous end-joining factor 1
NLRP7 NLR family, pyrin domain containing 7
NOD2 nucleotide-binding oligomerization domain containing 2
NODAL nodal growth differentiation factor
NOS3 nitric oxide synthase 3 (endothelial cell)
NOTCH3 notch 3
NPC1 Niemann-Pick disease, type C1
NPPB natriuretic peptide B
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NRP1 neuropilin 1
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OGG1 8-oxoguanine DNA glycosylase
OPA1 optic atrophy 1 (autosomal dominant)
OPRD1 opioid receptor, delta 1
OPRM1 opioid receptor, mu 1
PAH phenylalanine hydroxylase
PAPPA pregnancy-associated plasma protein A, pappalysin 1
PAX9 paired box 9
PDCD1 programmed cell death 1
PGF placental growth factor
PGR progesterone receptor
PHEX phosphate regulating endopeptidase homolog, X-linked
PIBF1 progesterone immunomodulatory binding factor 1
PICK1 protein interacting with PRKCA 1
PIDD1 p53-induced death domain protein 1
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PKD1 polycystic kidney disease 1 (autosomal dominant)
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PLAGL1 pleiomorphic adenoma gene-like 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
POLB polymerase (DNA directed), beta
POLH polymerase (DNA directed), eta
POLI polymerase (DNA directed) iota
POMC proopiomelanocortin
PRAME preferentially expressed antigen in melanoma
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRNP prion protein
PRSS1 protease, serine, 1 (trypsin 1)
PRTN3 proteinase 3
PTEN phosphatase and tensin homolog
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTX3 pentraxin 3, long
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAD18 RAD18 E3 ubiquitin protein ligase
RAD51 RAD51 recombinase
RB1 retinoblastoma 1
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
REN renin
REV1 REV1, polymerase (DNA directed)
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit
RHOA ras homolog family member A
RLN2 relaxin 2
RNASEH2B ribonuclease H2, subunit B
RORC RAR-related orphan receptor C
RUNX1 runt-related transcription factor 1
RYR2 ryanodine receptor 2 (cardiac)
S100A9 S100 calcium binding protein A9
S100B S100 calcium binding protein B
SCN2A sodium channel, voltage gated, type II alpha subunit
SELE selectin E
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SELPLG selectin P ligand
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
SERPINA12 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFTPA1 surfactant protein A1
SFTPA2 surfactant protein A2
SFTPD surfactant protein D
SGCA sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)
SHMT1 serine hydroxymethyltransferase 1 (soluble)
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SLX4 SLX4 structure-specific endonuclease subunit
SMAD4 SMAD family member 4
SMAD6 SMAD family member 6
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOCS3 suppressor of cytokine signaling 3
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5A signal transducer and activator of transcription 5A
STK24 serine/threonine kinase 24
SYT12 synaptotagmin XII
TAC1 tachykinin, precursor 1
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TCN2 transcobalamin II
TERT telomerase reverse transcriptase
TGFB1 transforming growth factor, beta 1
TGFBR1 transforming growth factor, beta receptor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBD thrombomodulin
TIMP2 TIMP metallopeptidase inhibitor 2
TLN1 talin 1
TLR2 toll-like receptor 2
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TNF tumor necrosis factor
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNNT2 troponin T type 2 (cardiac)
TP53 tumor protein p53
TP63 tumor protein p63
TPO thyroid peroxidase
TRA T cell receptor alpha locus
TRAF1 TNF receptor-associated factor 1
TREM1 triggering receptor expressed on myeloid cells 1
TREX1 three prime repair exonuclease 1
TSLP thymic stromal lymphopoietin
TSPO translocator protein (18kDa)
TTI1 TELO2 interacting protein 1
TTI2 TELO2 interacting protein 2
TTN titin
TUBB1 tubulin, beta 1 class VI
TYMS thymidylate synthetase
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A
VKORC1 vitamin K epoxide reductase complex, subunit 1
WLS wntless Wnt ligand secretion mediator
XRN2 5'-3' exoribonuclease 2
ZEB1 zinc finger E-box binding homeobox 1