srf_20709909_hematopoietic_stem_cell_lof_mouse_gpl1261_gds3732 Gene Set

Dataset GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations
Category transcriptomics
Type transcription factor perturbation
Description transcription factor perturbation identified as [TF gene symbol]_[publication PMID]_[cell or tissue]_[perturbation]_[organism]_[GEO platform]_[GEO accession] (Gene Expression Omnibus)
External Link http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GDS3732
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Genes

357 genes differentially expressed following the srf_20709909_hematopoietic_stem_cell_lof_mouse_gpl1261_gds3732 transcription factor perturbation from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.

increased expression

Symbol Name Standardized Value
LPAR1 lysophosphatidic acid receptor 1 0.211149
PCDH8 protocadherin 8 0.210926
RFPL4A ret finger protein-like 4A 0.208887
SAA3P serum amyloid A3 pseudogene 0.208106
GOLGB1 golgin B1 0.207922
KCNC1 potassium channel, voltage gated Shaw related subfamily C, member 1 0.206789
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.2044
TPM2 tropomyosin 2 (beta) 0.203797
PLA2G4B phospholipase A2, group IVB (cytosolic) 0.202101
IKZF1 IKAROS family zinc finger 1 (Ikaros) 0.20075
RNF141 ring finger protein 141 0.199967
KIAA1467 KIAA1467 0.199851
CD7 CD7 molecule 0.194205
PRM3 protamine 3 0.1897
ACSS1 acyl-CoA synthetase short-chain family member 1 0.188518
NDRG1 N-myc downstream regulated 1 0.187745
ACTC1 actin, alpha, cardiac muscle 1 0.187639
BMP1 bone morphogenetic protein 1 0.183794
FBXW4 F-box and WD repeat domain containing 4 0.183109
NR2F6 nuclear receptor subfamily 2, group F, member 6 0.18241
HLA-G major histocompatibility complex, class I, G 0.182273
MYO1H myosin IH 0.181833
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4 0.181667
PLEK pleckstrin 0.180826
ARHGAP24 Rho GTPase activating protein 24 0.180626
FGFR4 fibroblast growth factor receptor 4 0.17923
SYN2 synapsin II 0.176467
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.174971
TYROBP TYRO protein tyrosine kinase binding protein 0.172855
NFYB nuclear transcription factor Y, beta 0.171103
CAPN3 calpain 3, (p94) 0.170793
CD93 CD93 molecule 0.167791
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 0.166081
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 0.161747
RIT2 Ras-like without CAAX 2 0.161228
TUBB tubulin, beta class I 0.156047
OSTM1 osteopetrosis associated transmembrane protein 1 0.155968
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 0.155341
TMEM108 transmembrane protein 108 0.154761
NRSN2 neurensin 2 0.152411
SEPT10 septin 10 0.150651
RAP2B RAP2B, member of RAS oncogene family 0.150651
CCDC150 coiled-coil domain containing 150 0.14461
SLC18A1 solute carrier family 18 (vesicular monoamine transporter), member 1 0.1407
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide 0.134735
TTC13 tetratricopeptide repeat domain 13 0.134184
GPR151 G protein-coupled receptor 151 0.133963
UHRF1BP1L UHRF1 binding protein 1-like 0.133963
FCRL1 Fc receptor-like 1 0.129975
NEURL2 neuralized E3 ubiquitin protein ligase 2 0.128784
PPP1R16B protein phosphatase 1, regulatory subunit 16B 0.126326
TECRL trans-2,3-enoyl-CoA reductase-like 0.123875
SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2) 0.11953
ABI1 abl-interactor 1 0.117945
GNG2 guanine nucleotide binding protein (G protein), gamma 2 0.117542
GMFB glia maturation factor, beta 0.116135
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene 0.116027
LETMD1 LETM1 domain containing 1 0.115144
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 0.108805
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2 0.108362
DNTT DNA nucleotidylexotransferase 0.107994
THRAP3 thyroid hormone receptor associated protein 3 0.107107
ETNK1 ethanolamine kinase 1 0.106908
CNN3 calponin 3, acidic 0.106465
SATB1 SATB homeobox 1 0.100847
TSPAN2 tetraspanin 2 0.097953
ICOS inducible T-cell co-stimulator 0.091443
MFAP2 microfibrillar-associated protein 2 0.090259
CADM2 cell adhesion molecule 2 0.086664
TPM4 tropomyosin 4 0.083216
ATG12 autophagy related 12 0.077453
COL9A1 collagen, type IX, alpha 1 0.077009
C21ORF91 chromosome 21 open reading frame 91 0.070045
RBM47 RNA binding motif protein 47 0.067038
MRPL15 mitochondrial ribosomal protein L15 0.063204
SEC22C SEC22 vesicle trafficking protein homolog C (S. cerevisiae) 0.062448
NCOA7 nuclear receptor coactivator 7 0.061529
CNN2 calponin 2 0.060478
MRVI1 murine retrovirus integration site 1 homolog 0.060137
CD4 CD4 molecule 0.058994
ZEB2 zinc finger E-box binding homeobox 2 0.057558
MRPL30 mitochondrial ribosomal protein L30 0.057261
SRP72 signal recognition particle 72kDa 0.05652
RBMX RNA binding motif protein, X-linked 0.05402
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0534
MEF2C myocyte enhancer factor 2C 0.05337
SLA Src-like-adaptor 0.052338
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme 0.045427
TRPS1 trichorhinophalangeal syndrome I 0.044198
C10ORF10 chromosome 10 open reading frame 10 0.038521
KIF1A kinesin family member 1A 0.037211
NICN1 nicolin 1 0.033349
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 0.032367
DPPA2 developmental pluripotency associated 2 0.028447
LMOD2 leiomodin 2 (cardiac) 0.027831
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.025967
DSE dermatan sulfate epimerase 0.025306
SGK3 serum/glucocorticoid regulated kinase family, member 3 0.024803
PDE1A phosphodiesterase 1A, calmodulin-dependent 0.024038
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 0.020234
ARMC9 armadillo repeat containing 9 0.017205
ZXDA zinc finger, X-linked, duplicated A 0.013492
KDM5D lysine (K)-specific demethylase 5D 0.012642
TLR7 toll-like receptor 7 0.012145
CORO1A coronin, actin binding protein, 1A 0.010906
ADCY1 adenylate cyclase 1 (brain) 0.005618
KRTAP3-3 keratin associated protein 3-3 0.005498
ASPA aspartoacylase 0.003801
HIST2H2BE histone cluster 2, H2be 0.003421
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3 0.002614
TMEM183A transmembrane protein 183A 0.002543
GJB2 gap junction protein, beta 2, 26kDa 0.001764
PDZD4 PDZ domain containing 4 0.001273

decreased expression

Symbol Name Standardized Value
KLC3 kinesin light chain 3 -1.24006
SORBS2 sorbin and SH3 domain containing 2 -1.22552
RIOK3 RIO kinase 3 -1.22465
SYNC syncoilin, intermediate filament protein -1.20401
IDUA iduronidase, alpha-L- -1.19757
TMPPE transmembrane protein with metallophosphoesterase domain -1.17488
PCBP4 poly(rC) binding protein 4 -1.16991
MMP24 matrix metallopeptidase 24 (membrane-inserted) -1.15904
CIC capicua transcriptional repressor -1.14606
CAPN15 calpain 15 -1.14456
ZNF639 zinc finger protein 639 -1.13678
FBN1 fibrillin 1 -1.13369
NPY6R neuropeptide Y receptor Y6 (pseudogene) -1.12854
COL12A1 collagen, type XII, alpha 1 -1.12278
PLXDC2 plexin domain containing 2 -1.11732
FABP4 fatty acid binding protein 4, adipocyte -1.08736
SCN8A sodium channel, voltage gated, type VIII alpha subunit -1.0805
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae) -1.0727
ASB1 ankyrin repeat and SOCS box containing 1 -1.06685
EDC4 enhancer of mRNA decapping 4 -1.06657
GTF2IRD2 GTF2I repeat domain containing 2 -1.06529
ZNF598 zinc finger protein 598 -1.05988
FOXJ3 forkhead box J3 -1.04333
CEP126 centrosomal protein 126kDa -1.03712
MCL1 myeloid cell leukemia 1 -1.0356
ZNF655 zinc finger protein 655 -1.01936
ADCK1 aarF domain containing kinase 1 -1.0158
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40 -1.01273
TAPBPL TAP binding protein-like -1.00849
ABHD5 abhydrolase domain containing 5 -1.00613
NFIC nuclear factor I/C (CCAAT-binding transcription factor) -1.00468
RHOF ras homolog family member F (in filopodia) -0.999203
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -0.994309
ARL4A ADP-ribosylation factor-like 4A -0.987853
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase -0.983456
NFX1 nuclear transcription factor, X-box binding 1 -0.973472
PRKD1 protein kinase D1 -0.972074
LRWD1 leucine-rich repeats and WD repeat domain containing 1 -0.969979
EXD2 exonuclease 3'-5' domain containing 2 -0.969283
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced -0.964316
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled -0.939471
MYO1B myosin IB -0.929452
JAG1 jagged 1 -0.924159
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) -0.923685
C16ORF52 chromosome 16 open reading frame 52 -0.920556
ZFYVE21 zinc finger, FYVE domain containing 21 -0.91821
CHAF1B chromatin assembly factor 1, subunit B (p60) -0.914481
THOC3 THO complex 3 -0.913612
ESYT1 extended synaptotagmin-like protein 1 -0.912678
ZDHHC18 zinc finger, DHHC-type containing 18 -0.905781
DDX50 DEAD (Asp-Glu-Ala-Asp) box polypeptide 50 -0.880521
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 -0.867619
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 -0.859728
EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa -0.858984
TAF8 TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa -0.853034
GPSM1 G-protein signaling modulator 1 -0.850823
ALX4 ALX homeobox 4 -0.845759
BET1L Bet1 golgi vesicular membrane trafficking protein-like -0.84357
ALDOA aldolase A, fructose-bisphosphate -0.841393
LOC389895 chromosome 16 open reading frame 72-like -0.838557
VPS11 vacuolar protein sorting 11 homolog (S. cerevisiae) -0.837787
MOG myelin oligodendrocyte glycoprotein -0.836506
RYR1 ryanodine receptor 1 (skeletal) -0.835944
EEF2 eukaryotic translation elongation factor 2 -0.829129
SESTD1 SEC14 and spectrin domains 1 -0.828472
UBE4A ubiquitination factor E4A -0.826004
TIMP3 TIMP metallopeptidase inhibitor 3 -0.82425
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) -0.82116
TPST2 tyrosylprotein sulfotransferase 2 -0.814376
NTN4 netrin 4 -0.81095
NPDC1 neural proliferation, differentiation and control, 1 -0.810511
GKAP1 G kinase anchoring protein 1 -0.807934
MAP3K4 mitogen-activated protein kinase kinase kinase 4 -0.8058
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein -0.804302
XAB2 XPA binding protein 2 -0.800796
RTEL1 regulator of telomere elongation helicase 1 -0.792536
MPRIP myosin phosphatase Rho interacting protein -0.784414
TRPM2 transient receptor potential cation channel, subfamily M, member 2 -0.780951
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain -0.774197
RAB11FIP3 RAB11 family interacting protein 3 (class II) -0.773879
CCDC57 coiled-coil domain containing 57 -0.773879
HID1 HID1 domain containing -0.771798
SIPA1 signal-induced proliferation-associated 1 -0.763307
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1 -0.763219
SEC31A SEC31 homolog A (S. cerevisiae) -0.760877
ANKRD54 ankyrin repeat domain 54 -0.748405
FAM179B family with sequence similarity 179, member B -0.738615
PEF1 penta-EF-hand domain containing 1 -0.729368
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) -0.729121
TCAF1 TRPM8 channel-associated factor 1 -0.724676
MED19 mediator complex subunit 19 -0.723258
FMNL1 formin-like 1 -0.717078
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A -0.707861
RALGDS ral guanine nucleotide dissociation stimulator -0.701792
CAND1 cullin-associated and neddylation-dissociated 1 -0.69809
ZCCHC9 zinc finger, CCHC domain containing 9 -0.693592
MAP2K3 mitogen-activated protein kinase kinase 3 -0.693103
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.691793
NNAT neuronatin -0.691532
NEFL neurofilament, light polypeptide -0.678746
NT5C2 5'-nucleotidase, cytosolic II -0.674539
LIMK1 LIM domain kinase 1 -0.673755
CBX4 chromobox homolog 4 -0.668377
RBM39 RNA binding motif protein 39 -0.664671
ATXN2L ataxin 2-like -0.658954
RAF1 Raf-1 proto-oncogene, serine/threonine kinase -0.652375
SBF1 SET binding factor 1 -0.647958
SEPT3 septin 3 -0.63929
NT5E 5'-nucleotidase, ecto (CD73) -0.636734
DIO2 deiodinase, iodothyronine, type II -0.634898
WDR61 WD repeat domain 61 -0.631467
C2 complement component 2 -0.627727
NAA35 N(alpha)-acetyltransferase 35, NatC auxiliary subunit -0.623623
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.619904
GAA glucosidase, alpha; acid -0.619367
EFNA1 ephrin-A1 -0.616031
EMILIN1 elastin microfibril interfacer 1 -0.615767
KLHL26 kelch-like family member 26 -0.615301
TMEM57 transmembrane protein 57 -0.607066
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.605393
PRSS51 protease, serine, 51 -0.602963
TSSK1B testis-specific serine kinase 1B -0.60271
GHDC GH3 domain containing -0.600748
GOLGA4 golgin A4 -0.597914
URGCP upregulator of cell proliferation -0.5953
EHF ets homologous factor -0.59493
FBXO4 F-box protein 4 -0.580023
UBE3B ubiquitin protein ligase E3B -0.577154
VPS9D1 VPS9 domain containing 1 -0.573803
SLCO2B1 solute carrier organic anion transporter family, member 2B1 -0.571799
SLX4 SLX4 structure-specific endonuclease subunit -0.570427
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1 -0.569298
MEN1 multiple endocrine neoplasia I -0.563759
SLC25A25 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25 -0.562933
BICD1 bicaudal D homolog 1 (Drosophila) -0.559646
INPP5D inositol polyphosphate-5-phosphatase, 145kDa -0.55118
ARHGAP1 Rho GTPase activating protein 1 -0.550081
AFTPH aftiphilin -0.543921
RNF125 ring finger protein 125, E3 ubiquitin protein ligase -0.543616
ZBTB5 zinc finger and BTB domain containing 5 -0.542648
PRKCH protein kinase C, eta -0.542546
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -0.541378
LZTR1 leucine-zipper-like transcription regulator 1 -0.539165
UBP1 upstream binding protein 1 (LBP-1a) -0.536777
SMOX spermine oxidase -0.535684
KLHL2 kelch-like family member 2 -0.534993
SIN3A SIN3 transcription regulator family member A -0.533576
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase) -0.529794
STX17 syntaxin 17 -0.520127
CCNJL cyclin J-like -0.518342
TSSC4 tumor suppressing subtransferable candidate 4 -0.514736
ZNF513 zinc finger protein 513 -0.506989
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 -0.506391
TMEM8A transmembrane protein 8A -0.505405
NOVA1 neuro-oncological ventral antigen 1 -0.499091
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.498153
SPON2 spondin 2, extracellular matrix protein -0.497339
LINGO3 leucine rich repeat and Ig domain containing 3 -0.496281
SESN2 sestrin 2 -0.489976
PRDM10 PR domain containing 10 -0.489511
XPO5 exportin 5 -0.489047
TSPAN7 tetraspanin 7 -0.487505
FAM149B1 family with sequence similarity 149, member B1 -0.486431
PER1 period circadian clock 1 -0.484811
FAM161A family with sequence similarity 161, member A -0.484512
ERCC2 excision repair cross-complementation group 2 -0.484324
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta -0.482749
APOB apolipoprotein B -0.479814
MAP9 microtubule-associated protein 9 -0.476895
RAB27B RAB27B, member RAS oncogene family -0.476328
ZNF335 zinc finger protein 335 -0.475866
PPP1R12C protein phosphatase 1, regulatory subunit 12C -0.474944
IRAK1 interleukin-1 receptor-associated kinase 1 -0.472718
MIER2 mesoderm induction early response 1, family member 2 -0.470926
ATXN7L2 ataxin 7-like 2 -0.470311
TRO trophinin -0.469975
ZFP64 ZFP64 zinc finger protein -0.46487
SAFB scaffold attachment factor B -0.461917
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.461759
SRF serum response factor (c-fos serum response element-binding transcription factor) -0.461097
PRDM4 PR domain containing 4 -0.459556
NELFB negative elongation factor complex member B -0.458851
CSN1S2AP casein alpha s2-like A, pseudogene -0.456864
PEX6 peroxisomal biogenesis factor 6 -0.455125
CABLES1 Cdk5 and Abl enzyme substrate 1 -0.448833
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.447474
TMEM161A transmembrane protein 161A -0.445864
NISCH nischarin -0.444469
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae) -0.444229
CERK ceramide kinase -0.441205
FPR3 formyl peptide receptor 3 -0.440689
PYGL phosphorylase, glycogen, liver -0.43814
ZNF341 zinc finger protein 341 -0.437096
GATAD1 GATA zinc finger domain containing 1 -0.435915
SCRN1 secernin 1 -0.431456
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.42928
HMGN3 high mobility group nucleosomal binding domain 3 -0.428334
PACS2 phosphofurin acidic cluster sorting protein 2 -0.425165
HCK HCK proto-oncogene, Src family tyrosine kinase -0.065282
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35) -0.065122
NKG7 natural killer cell granule protein 7 -0.06402
PKIB protein kinase (cAMP-dependent, catalytic) inhibitor beta -0.060247
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X -0.059954
RFX2 regulatory factor X, 2 (influences HLA class II expression) -0.058531
HCFC1 host cell factor C1 -0.058401
WDR1 WD repeat domain 1 -0.058251
GLT6D1 glycosyltransferase 6 domain containing 1 -0.057479
TSPAN9 tetraspanin 9 -0.056604
TCEB3 transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A) -0.055788
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 -0.053159
UBALD1 UBA-like domain containing 1 -0.0531
IVNS1ABP influenza virus NS1A binding protein -0.052787
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 -0.052767
RABGAP1L RAB GTPase activating protein 1-like -0.052532
ACTG1 actin gamma 1 -0.051398
FAM63A family with sequence similarity 63, member A -0.051199
HIST1H2BC histone cluster 1, H2bc -0.050464
ANKRD44 ankyrin repeat domain 44 -0.049749
C10ORF107 chromosome 10 open reading frame 107 -0.044515
LIN7C lin-7 homolog C (C. elegans) -0.043958
ADAM1B ADAM metallopeptidase domain 1B (pseudogene) -0.039486
CASR calcium-sensing receptor -0.038896
NTNG1 netrin G1 -0.03744
IL13 interleukin 13 -0.03447
PHF7 PHD finger protein 7 -0.030362
CDH13 cadherin 13 -0.02674
EIF3C eukaryotic translation initiation factor 3, subunit C -0.022254
TXNDC15 thioredoxin domain containing 15 -0.020553
FAM69A family with sequence similarity 69, member A -0.019764
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group) -0.019225
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae) -0.0164
OSGEP O-sialoglycoprotein endopeptidase -0.015151
PCDHA10 protocadherin alpha 10 -0.013011
YIPF3 Yip1 domain family, member 3 -0.011431
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated) -0.011339
IL6R interleukin 6 receptor -0.007109
ACTB actin, beta -0.006786
PHF3 PHD finger protein 3 -0.005285
P2RY12 purinergic receptor P2Y, G-protein coupled, 12 -0.00489
ARPP21 cAMP-regulated phosphoprotein, 21kDa -0.00438
ANKRD33B ankyrin repeat domain 33B -0.003941
EARS2 glutamyl-tRNA synthetase 2, mitochondrial -0.002316
NUP155 nucleoporin 155kDa -0.001433
OBFC1 oligonucleotide/oligosaccharide-binding fold containing 1 -0.001015
Funding