stat1 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description signal transducer and activator of transcription 1, 91kDa|The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 6772)
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Genes

203 genes co-occuring with the biological term stat1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ALOX15 arachidonate 15-lipoxygenase
ALOX5 arachidonate 5-lipoxygenase
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
APOC2 apolipoprotein C-II
APOE apolipoprotein E
ARRB1 arrestin, beta 1
BAD BCL2-associated agonist of cell death
BAX BCL2-associated X protein
BCL2 B-cell CLL/lymphoma 2
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BCR breakpoint cluster region
BHLHE40 basic helix-loop-helix family, member e40
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA1 breast cancer 1, early onset
C3 complement component 3
C4B complement component 4B (Chido blood group)
CASP2 caspase 2, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP6 caspase 6, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCL5 chemokine (C-C motif) ligand 5
CD200 CD200 molecule
CD274 CD274 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDK8 cyclin-dependent kinase 8
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon
CENPW centromere protein W
CIITA class II, major histocompatibility complex, transactivator
COPS5 COP9 signalosome subunit 5
CREBBP CREB binding protein
CSF1 colony stimulating factor 1 (macrophage)
CSTB cystatin B (stefin B)
CTGF connective tissue growth factor
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL8 chemokine (C-X-C motif) ligand 8
CYSLTR1 cysteinyl leukotriene receptor 1
DDB1 damage-specific DNA binding protein 1, 127kDa
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DEFB4A defensin, beta 4A
DTX3L deltex 3 like, E3 ubiquitin ligase
DUOX2 dual oxidase 2
DUOXA2 dual oxidase maturation factor 2
EGFR epidermal growth factor receptor
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB4 erb-b2 receptor tyrosine kinase 4
ESR1 estrogen receptor 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FAS Fas cell surface death receptor
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)
FGF2 fibroblast growth factor 2 (basic)
FGFR3 fibroblast growth factor receptor 3
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXP3 forkhead box P3
GBP1 guanylate binding protein 1, interferon-inducible
GC group-specific component (vitamin D binding protein)
GLS glutaminase
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
GSK3B glycogen synthase kinase 3 beta
HAMP hepcidin antimicrobial peptide
HLA-B major histocompatibility complex, class I, B
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPB1 heat shock 27kDa protein 1
HTATSF1 HIV-1 Tat specific factor 1
ICAM1 intercellular adhesion molecule 1
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IFN1@ interferon, type 1, cluster
IFNA1 interferon, alpha 1
IFNA2 interferon, alpha 2
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFNB1 interferon, beta 1, fibroblast
IFNE interferon, epsilon
IFNG interferon, gamma
IFNGR1 interferon gamma receptor 1
IGBP1 immunoglobulin (CD79A) binding protein 1
IGFBP3 insulin-like growth factor binding protein 3
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IL10 interleukin 10
IL12B interleukin 12B
IL13 interleukin 13
IL15 interleukin 15
IL17A interleukin 17A
IL18BP interleukin 18 binding protein
IL21 interleukin 21
IL22 interleukin 22
IL23R interleukin 23 receptor
IL26 interleukin 26
IL27 interleukin 27
IL27RA interleukin 27 receptor, alpha
IL2RA interleukin 2 receptor, alpha
IL31 interleukin 31
IL4 interleukin 4
IL6 interleukin 6
IL7 interleukin 7
IRAK1 interleukin-1 receptor-associated kinase 1
IRAK3 interleukin-1 receptor-associated kinase 3
IRF1 interferon regulatory factor 1
IRF4 interferon regulatory factor 4
IRF5 interferon regulatory factor 5
IRF7 interferon regulatory factor 7
IRF8 interferon regulatory factor 8
IRF9 interferon regulatory factor 9
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
JAK1 Janus kinase 1
JAK2 Janus kinase 2
JUN jun proto-oncogene
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KLRK1 killer cell lectin-like receptor subfamily K, member 1
KPNA1 karyopherin alpha 1 (importin alpha 5)
KPNA5 karyopherin alpha 5 (importin alpha 6)
KRT17 keratin 17, type I
LCN2 lipocalin 2
LY96 lymphocyte antigen 96
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MIR145 microRNA 145
MIR146A microRNA 146a
MIR224 microRNA 224
MMP1 matrix metallopeptidase 1
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MUC1 mucin 1, cell surface associated
MUC4 mucin 4, cell surface associated
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCF2 neutrophil cytosolic factor 2
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NMI N-myc (and STAT) interactor
NOS2 nitric oxide synthase 2, inducible
NR1H4 nuclear receptor subfamily 1, group H, member 4
NUCLEOLIN nucleolin multifunctional protein
OASL 2'-5'-oligoadenylate synthetase-like
OSM oncostatin M
PARP14 poly (ADP-ribose) polymerase family, member 14
PARP9 poly (ADP-ribose) polymerase family, member 9
PCBP2 poly(rC) binding protein 2
PDCD1 programmed cell death 1
PIAS1 protein inhibitor of activated STAT, 1
PLSCR1 phospholipid scramblase 1
PPARG peroxisome proliferator-activated receptor gamma
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PRKCD protein kinase C, delta
PRKCE protein kinase C, epsilon
PTGIR prostaglandin I2 (prostacyclin) receptor (IP)
PTK2 protein tyrosine kinase 2
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RARB retinoic acid receptor, beta
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
REST RE1-silencing transcription factor
RET ret proto-oncogene
S100A7 S100 calcium binding protein A7
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SHH sonic hedgehog
SIRT2 sirtuin 2
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SMAD1 SMAD family member 1
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SNAI2 snail family zinc finger 2
SOCS1 suppressor of cytokine signaling 1
SOCS3 suppressor of cytokine signaling 3
SOD1 superoxide dismutase 1, soluble
SP1 Sp1 transcription factor
SPI1 Spi-1 proto-oncogene
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT2 signal transducer and activator of transcription 2, 113kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT4 signal transducer and activator of transcription 4
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
SUMO1 small ubiquitin-like modifier 1
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TBX21 T-box 21
TEK TEK tyrosine kinase, endothelial
TIMP1 TIMP metallopeptidase inhibitor 1
TJP2 tight junction protein 2
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TLR8 toll-like receptor 8
TMEFF2 transmembrane protein with EGF-like and two follistatin-like domains 2
TNF tumor necrosis factor
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNK1 tyrosine kinase, non-receptor, 1
TP53 tumor protein p53
TP73 tumor protein p73
TRIM28 tripartite motif containing 28
TRIM6 tripartite motif containing 6
TYK2 tyrosine kinase 2
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3)
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
XAF1 XIAP associated factor 1
YES1 YES proto-oncogene 1, Src family tyrosine kinase