stat1 Gene Set

Dataset Phosphosite Textmining Biological Term Annotations
Category structural or functional annotations
Type biological term
Description signal transducer and activator of transcription 1, 91kDa|The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 6772)
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Genes

66 proteins co-occuring with the biological term stat1 in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

Symbol Name
AKT1 v-akt murine thymoma viral oncogene homolog 1
ATF2 activating transcription factor 2
BANP BTG3 associated nuclear protein
CREB1 cAMP responsive element binding protein 1
CSF1R colony stimulating factor 1 receptor
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
DDR1 discoidin domain receptor tyrosine kinase 1
EGFR epidermal growth factor receptor
EIF4E eukaryotic translation initiation factor 4E
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ELK1 ELK1, member of ETS oncogene family
EPOR erythropoietin receptor
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB4 erb-b2 receptor tyrosine kinase 4
ETV6 ets variant 6
FGFR3 fibroblast growth factor receptor 3
GHR growth hormone receptor
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
H2AFX H2A histone family, member X
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFNAR2 interferon (alpha, beta and omega) receptor 2
IFNGR1 interferon gamma receptor 1
IL21R interleukin 21 receptor
IL2RB interleukin 2 receptor, beta
IL6ST interleukin 6 signal transducer
IL9R interleukin 9 receptor
IRF3 interferon regulatory factor 3
IRF8 interferon regulatory factor 8
JAK1 Janus kinase 1
JAK2 Janus kinase 2
JUN jun proto-oncogene
LEPR leptin receptor
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAP2K3 mitogen-activated protein kinase kinase 3
MAP2K6 mitogen-activated protein kinase kinase 6
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
OSMR oncostatin M receptor
PDLIM2 PDZ and LIM domain 2 (mystique)
PIAS1 protein inhibitor of activated STAT, 1
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
PRKCD protein kinase C, delta
PRKCE protein kinase C, epsilon
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator
RB1 retinoblastoma 1
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RPS6 ribosomal protein S6
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT2 signal transducer and activator of transcription 2, 113kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT4 signal transducer and activator of transcription 4
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
TYK2 tyrosine kinase 2