stat2 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description signal transducer and activator of transcription 2, 113kDa|The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010] (NCBI Entrez Gene Database, 6773)
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Genes

35 genes co-occuring with the biological term stat2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
BRCA1 breast cancer 1, early onset
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon
CLDN4 claudin 4
CREBBP CREB binding protein
CXCL8 chemokine (C-X-C motif) ligand 8
DDB1 damage-specific DNA binding protein 1, 127kDa
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IFNA1 interferon, alpha 1
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFNAR2 interferon (alpha, beta and omega) receptor 2
IFNB1 interferon, beta 1, fibroblast
IFNG interferon, gamma
IRF1 interferon regulatory factor 1
IRF7 interferon regulatory factor 7
IRF8 interferon regulatory factor 8
IRF9 interferon regulatory factor 9
JAK1 Janus kinase 1
JUND jun D proto-oncogene
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
PCBP2 poly(rC) binding protein 2
PDCD1 programmed cell death 1
RCAN1 regulator of calcineurin 1
RUVBL1 RuvB-like AAA ATPase 1
RUVBL2 RuvB-like AAA ATPase 2
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SOCS1 suppressor of cytokine signaling 1
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT2 signal transducer and activator of transcription 2, 113kDa
TP53 tumor protein p53
TP73 tumor protein p73
TYK2 tyrosine kinase 2
UBR4 ubiquitin protein ligase E3 component n-recognin 4