stat3_00000000_a549_lof_human_gpl571_gse42979 Gene Set

Dataset GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations
Category transcriptomics
Type transcription factor perturbation
Description transcription factor perturbation identified as [TF gene symbol]_[publication PMID]_[cell or tissue]_[perturbation]_[organism]_[GEO platform]_[GEO accession] (Gene Expression Omnibus)
External Link http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE42979
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Genes

270 genes differentially expressed following the stat3_00000000_a549_lof_human_gpl571_gse42979 transcription factor perturbation from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.

increased expression

Symbol Name Standardized Value
CBS cystathionine-beta-synthase 0.223241
HEXIM1 hexamethylene bis-acetamide inducible 1 0.222042
NUP210 nucleoporin 210kDa 0.213691
MBD4 methyl-CpG binding domain protein 4 0.202247
PMS2P1 postmeiotic segregation increased 2 pseudogene 1 0.199043
XPO7 exportin 7 0.198881
NFATC2IP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein 0.197074
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B 0.196224
WBSCR22 Williams Beuren syndrome chromosome region 22 0.195007
ACAT1 acetyl-CoA acetyltransferase 1 0.193286
TGIF1 TGFB-induced factor homeobox 1 0.192961
CENPA centromere protein A 0.192428
GPR176 G protein-coupled receptor 176 0.191227
UBE2D2 ubiquitin-conjugating enzyme E2D 2 0.190059
DNAI2 dynein, axonemal, intermediate chain 2 0.186974
SMNDC1 survival motor neuron domain containing 1 0.185241
PTTG1 pituitary tumor-transforming 1 0.179828
VRK3 vaccinia related kinase 3 0.179736
TDP1 tyrosyl-DNA phosphodiesterase 1 0.177487
SYNPO2L synaptopodin 2-like 0.174356
UBXN8 UBX domain protein 8 0.174187
AQP3 aquaporin 3 (Gill blood group) 0.173539
EIF5 eukaryotic translation initiation factor 5 0.171738
INTS1 integrator complex subunit 1 0.168897
HIST1H3A histone cluster 1, H3a 0.163171
RAB11FIP3 RAB11 family interacting protein 3 (class II) 0.1617
RANBP9 RAN binding protein 9 0.159848
PPP1R3C protein phosphatase 1, regulatory subunit 3C 0.158596
PYY2 peptide YY, 2 (pseudogene) 0.157793
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.154917
FAT2 FAT atypical cadherin 2 0.154714
TCP11L1 t-complex 11, testis-specific-like 1 0.154193
IGLV3-19 immunoglobulin lambda variable 3-19 0.154004
PYY peptide YY 0.145793
TMEM108 transmembrane protein 108 0.143791
AURKA aurora kinase A 0.141615
CREB3L2 cAMP responsive element binding protein 3-like 2 0.137976
ARF1 ADP-ribosylation factor 1 0.134672
UXT ubiquitously-expressed, prefoldin-like chaperone 0.123204
VASH2 vasohibin 2 0.121535
GPX5 glutathione peroxidase 5 0.11883
DEPTOR DEP domain containing MTOR-interacting protein 0.117001
RB1CC1 RB1-inducible coiled-coil 1 0.101724
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.101679
BTNL8 butyrophilin-like 8 0.099503
GLRA2 glycine receptor, alpha 2 0.096887
ZNF276 zinc finger protein 276 0.094986
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2) 0.092037
TRIM65 tripartite motif containing 65 0.090392
HSF1 heat shock transcription factor 1 0.084367
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme 0.078113
ZBTB44 zinc finger and BTB domain containing 44 0.075936
MAPKAPK5-AS1 MAPKAPK5 antisense RNA 1 0.075366
CRNN cornulin 0.073659
RAB3B RAB3B, member RAS oncogene family 0.072865
CNR1 cannabinoid receptor 1 (brain) 0.067122
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.064127
SPANXA1 sperm protein associated with the nucleus, X-linked, family member A1 0.064059
PHGDH phosphoglycerate dehydrogenase 0.061338
ETV1 ets variant 1 0.061188
ASNS asparagine synthetase (glutamine-hydrolyzing) 0.060573
HNRNPA1P18 heterogeneous nuclear ribonucleoprotein A1 pseudogene 18 0.058424
GDF10 growth differentiation factor 10 0.057194
FBXO11 F-box protein 11 0.057167
IRS1 insulin receptor substrate 1 0.055806
GSE1 Gse1 coiled-coil protein 0.054974
ZMYND8 zinc finger, MYND-type containing 8 0.052273
CACTIN cactin, spliceosome C complex subunit 0.049538
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.048951
ZNF467 zinc finger protein 467 0.048864
SSRP1 structure specific recognition protein 1 0.047873
KLRD1 killer cell lectin-like receptor subfamily D, member 1 0.041857
ANP32D acidic (leucine-rich) nuclear phosphoprotein 32 family, member D 0.037231
ENOSF1 enolase superfamily member 1 0.03592
POM121L9P POM121 transmembrane nucleoporin-like 9, pseudogene 0.035781
ASRGL1 asparaginase like 1 0.034922
MTX1 metaxin 1 0.030175
TMEM2 transmembrane protein 2 0.029552
WDR59 WD repeat domain 59 0.028364
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4 0.022377
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10 0.022325
SNX24 sorting nexin 24 0.016933
ZNF500 zinc finger protein 500 0.012201
ZNF287 zinc finger protein 287 0.012201
KIAA0408 KIAA0408 0.011428
PDK2 pyruvate dehydrogenase kinase, isozyme 2 0.006677
LRRN2 leucine rich repeat neuronal 2 0.003449
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 0.002684
ATN1 atrophin 1 6.28E-4

decreased expression

Symbol Name Standardized Value
TFF1 trefoil factor 1 -1.36716
CELF1 CUGBP, Elav-like family member 1 -1.36139
RAB6A RAB6A, member RAS oncogene family -1.34548
KIAA1217 KIAA1217 -1.3112
SCML1 sex comb on midleg-like 1 (Drosophila) -1.19797
CELA2B chymotrypsin-like elastase family, member 2B -1.18825
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A -1.17738
SCGB2A1 secretoglobin, family 2A, member 1 -1.16937
CD163 CD163 molecule -1.16423
NLRX1 NLR family member X1 -1.16254
NCF2 neutrophil cytosolic factor 2 -1.15235
ANKRD7 ankyrin repeat domain 7 -1.15128
KLF6 Kruppel-like factor 6 -1.12779
HTRA1 HtrA serine peptidase 1 -1.11978
BDKRB2 bradykinin receptor B2 -1.11673
FHL2 four and a half LIM domains 2 -1.09342
CCL7 chemokine (C-C motif) ligand 7 -1.04375
WDR41 WD repeat domain 41 -1.03883
TOR1B torsin family 1, member B (torsin B) -1.03746
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6 -1.02749
MYD88 myeloid differentiation primary response 88 -1.01627
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -1.01593
CDC14A cell division cycle 14A -1.01339
ZNF552 zinc finger protein 552 -1.01173
ZCCHC24 zinc finger, CCHC domain containing 24 -1.00455
KIAA0930 KIAA0930 -0.999662
MDM1 Mdm1 nuclear protein homolog (mouse) -0.981274
LRRN3 leucine rich repeat neuronal 3 -0.977832
SMAD7 SMAD family member 7 -0.972456
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -0.952586
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 -0.948042
ALPI alkaline phosphatase, intestinal -0.946396
ZBED5 zinc finger, BED-type containing 5 -0.935544
CNTNAP2 contactin associated protein-like 2 -0.934762
FOXD4L1 forkhead box D4-like 1 -0.933563
ATF3 activating transcription factor 3 -0.924872
PGGT1B protein geranylgeranyltransferase type I, beta subunit -0.896592
CLDN3 claudin 3 -0.890268
ERAP1 endoplasmic reticulum aminopeptidase 1 -0.88926
ILK integrin-linked kinase -0.884299
PPP3CC protein phosphatase 3, catalytic subunit, gamma isozyme -0.870881
ITM2A integral membrane protein 2A -0.868432
PCDHA6 protocadherin alpha 6 -0.868052
RING1 ring finger protein 1 -0.860154
TMCO1 transmembrane and coiled-coil domains 1 -0.857757
TOR1AIP2 torsin A interacting protein 2 -0.830344
CTGF connective tissue growth factor -0.800031
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B -0.789766
NAV3 neuron navigator 3 -0.787246
L1CAM L1 cell adhesion molecule -0.769234
SC5D sterol-C5-desaturase -0.767935
HRK harakiri, BCL2 interacting protein -0.762378
EGR3 early growth response 3 -0.761097
RIN2 Ras and Rab interactor 2 -0.760216
ALDH1A3 aldehyde dehydrogenase 1 family, member A3 -0.754229
PLTP phospholipid transfer protein -0.747378
EIF1AX eukaryotic translation initiation factor 1A, X-linked -0.74
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 -0.727567
ANXA2 annexin A2 -0.709852
NFE2L3 nuclear factor, erythroid 2-like 3 -0.705144
WWTR1 WW domain containing transcription regulator 1 -0.698698
DCP1A decapping mRNA 1A -0.692354
GSN gelsolin -0.687112
PRKCA protein kinase C, alpha -0.683068
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.677086
PHF3 PHD finger protein 3 -0.676762
TBC1D9B TBC1 domain family, member 9B (with GRAM domain) -0.673862
BRSK2 BR serine/threonine kinase 2 -0.668236
TARP TCR gamma alternate reading frame protein -0.663561
BTF3P11 basic transcription factor 3 pseudogene 11 -0.660929
NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit -0.655275
LYPLA2 lysophospholipase II -0.653459
GAR1 GAR1 ribonucleoprotein -0.65331
PDZK1 PDZ domain containing 1 -0.652405
GBP1 guanylate binding protein 1, interferon-inducible -0.646147
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.642178
AMIGO2 adhesion molecule with Ig-like domain 2 -0.634099
FLII flightless I homolog (Drosophila) -0.632254
SEPHS2 selenophosphate synthetase 2 -0.631477
CBX2 chromobox homolog 2 -0.626774
SECTM1 secreted and transmembrane 1 -0.619471
TGFBI transforming growth factor, beta-induced, 68kDa -0.618858
KIR3DX1 killer cell immunoglobulin-like receptor, three domains, X1 -0.61723
CLCN7 chloride channel, voltage-sensitive 7 -0.617163
DUSP3 dual specificity phosphatase 3 -0.615884
RPH3AL rabphilin 3A-like (without C2 domains) -0.604444
PISD phosphatidylserine decarboxylase -0.599553
SMAGP small cell adhesion glycoprotein -0.59949
PPAP2A phosphatidic acid phosphatase type 2A -0.578201
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.574609
CCKAR cholecystokinin A receptor -0.574434
THRAP3 thyroid hormone receptor associated protein 3 -0.567508
TUBA4B tubulin, alpha 4b -0.564671
SYTL2 synaptotagmin-like 2 -0.564274
ICAM1 intercellular adhesion molecule 1 -0.563602
CRLF1 cytokine receptor-like factor 1 -0.562317
PALM2-AKAP2 PALM2-AKAP2 readthrough -0.558433
C19ORF26 chromosome 19 open reading frame 26 -0.555974
DDX24 DEAD (Asp-Glu-Ala-Asp) box helicase 24 -0.552778
TMEM246 transmembrane protein 246 -0.551914
GSN-AS1 GSN antisense RNA 1 -0.545309
MT1G metallothionein 1G -0.541687
ACTG1 actin gamma 1 -0.534155
NPY2R neuropeptide Y receptor Y2 -0.53095
SLC26A10 solute carrier family 26, member 10 -0.529821
MUC3A mucin 3A, cell surface associated -0.524477
KRI1 KRI1 homolog (S. cerevisiae) -0.523153
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor -0.522682
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase) -0.522495
MAGEC2 melanoma antigen family C2 -0.519357
OXSR1 oxidative stress responsive 1 -0.514498
SDC4 syndecan 4 -0.508524
LAMC1 laminin, gamma 1 (formerly LAMB2) -0.507302
CELA3A chymotrypsin-like elastase family, member 3A -0.506563
ELOVL1 ELOVL fatty acid elongase 1 -0.506216
SPN sialophorin -0.493776
SLC13A3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 -0.491967
FOXO1 forkhead box O1 -0.491967
GLTP glycolipid transfer protein -0.484321
PGAP3 post-GPI attachment to proteins 3 -0.484283
RNF138 ring finger protein 138, E3 ubiquitin protein ligase -0.481043
VAMP8 vesicle-associated membrane protein 8 -0.473777
TM2D1 TM2 domain containing 1 -0.473145
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.473076
IRS4 insulin receptor substrate 4 -0.466582
MAPRE1 microtubule-associated protein, RP/EB family, member 1 -0.463118
ROR1 receptor tyrosine kinase-like orphan receptor 1 -0.459379
CYFIP2 cytoplasmic FMR1 interacting protein 2 -0.459037
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) -0.458292
MFAP3L microfibrillar-associated protein 3-like -0.458106
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.456494
NFIB nuclear factor I/B -0.454408
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7 -0.454199
FAM208A family with sequence similarity 208, member A -0.450927
RAD51D RAD51 paralog D -0.448917
RPL6 ribosomal protein L6 -0.447848
S100A6 S100 calcium binding protein A6 -0.44653
SLC25A44 solute carrier family 25, member 44 -0.44563
CD59 CD59 molecule, complement regulatory protein -0.444461
RNF185 ring finger protein 185 -0.442645
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 -0.440991
TMEM109 transmembrane protein 109 -0.439332
PARVB parvin, beta -0.060727
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1 -0.059443
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.058972
LPPR4 lipid phosphate phosphatase-related protein type 4 -0.058371
ODF2 outer dense fiber of sperm tails 2 -0.057519
APOO apolipoprotein O -0.057021
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type -0.055645
UBTF upstream binding transcription factor, RNA polymerase I -0.051875
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6 -0.049706
CRYBB2 crystallin, beta B2 -0.048984
USP5 ubiquitin specific peptidase 5 (isopeptidase T) -0.048114
DARS2 aspartyl-tRNA synthetase 2, mitochondrial -0.047488
FMOD fibromodulin -0.045567
CBR4 carbonyl reductase 4 -0.038912
PFDN4 prefoldin subunit 4 -0.036889
RBM47 RNA binding motif protein 47 -0.03629
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1 -0.035884
ZWINT ZW10 interacting kinetochore protein -0.03567
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B -0.035023
ABCB7 ATP-binding cassette, sub-family B (MDR/TAP), member 7 -0.034764
NUSAP1 nucleolar and spindle associated protein 1 -0.033057
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -0.031028
PPP1R3A protein phosphatase 1, regulatory subunit 3A -0.030657
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 -0.030349
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.028545
TERF2IP telomeric repeat binding factor 2, interacting protein -0.025976
LCMT1 leucine carboxyl methyltransferase 1 -0.023049
ANKRD36B ankyrin repeat domain 36B -0.019961
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 -0.017922
RXRA retinoid X receptor, alpha -0.015851
RPS2 ribosomal protein S2 -0.015713
PMS2P3 postmeiotic segregation increased 2 pseudogene 3 -0.014864
GOLGA2 golgin A2 -0.014246
CREBZF CREB/ATF bZIP transcription factor -0.011627
TMPO thymopoietin -0.00969
RBM14 RNA binding motif protein 14 -0.008212
MTMR12 myotubularin related protein 12 -0.007886
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 -0.005843
CABIN1 calcineurin binding protein 1 -0.001574