stat4 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description signal transducer and activator of transcription 4|The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011] (NCBI Entrez Gene Database, 6775)
Similar Terms
Downloads & Tools

Genes

40 genes co-occuring with the biological term stat4 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
BANK1 B-cell scaffold protein with ankyrin repeats 1
BLK BLK proto-oncogene, Src family tyrosine kinase
C1QA complement component 1, q subcomponent, A chain
C5 complement component 5
CHRM3 cholinergic receptor, muscarinic 3
CTLA4 cytotoxic T-lymphocyte-associated protein 4
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FAM167A family with sequence similarity 167, member A
GATA3 GATA binding protein 3
HLA-DRA major histocompatibility complex, class II, DR alpha
IFNA1 interferon, alpha 1
IFNAR2 interferon (alpha, beta and omega) receptor 2
IFNG interferon, gamma
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL12A interleukin 12A
IL17A interleukin 17A
IL2 interleukin 2
IL21 interleukin 21
IL23R interleukin 23 receptor
IRF5 interferon regulatory factor 5
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
MIR132 microRNA 132
MIR141 microRNA 141
MIR200A microRNA 200a
MIR212 microRNA 212
NAA25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NOS3 nitric oxide synthase 3 (endothelial cell)
PADI4 peptidyl arginine deiminase, type IV
PIAS2 protein inhibitor of activated STAT, 2
PRF1 perforin 1 (pore forming protein)
S100A4 S100 calcium binding protein A4
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT4 signal transducer and activator of transcription 4
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
TBX21 T-box 21
TGFB1 transforming growth factor, beta 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRAF1 TNF receptor-associated factor 1