stat5a Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description signal transducer and activator of transcription 5A|The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013] (NCBI Entrez Gene Database, 6776)
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Genes

32 genes co-occuring with the biological term stat5a in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
ALK anaplastic lymphoma receptor tyrosine kinase
BCL2 B-cell CLL/lymphoma 2
CALR calreticulin
CD80 CD80 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
ERBB4 erb-b2 receptor tyrosine kinase 4
FOXO3 forkhead box O3
FYN FYN proto-oncogene, Src family tyrosine kinase
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HPSE heparanase
IL2RB interleukin 2 receptor, beta
IL3RA interleukin 3 receptor, alpha (low affinity)
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
IVL involucrin
JAK2 Janus kinase 2
MIR222 microRNA 222
MIR223 microRNA 223
MYB v-myb avian myeloblastosis viral oncogene homolog
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
PGR progesterone receptor
PPARG peroxisome proliferator-activated receptor gamma
PRLR prolactin receptor
PTPN1 protein tyrosine phosphatase, non-receptor type 1
SAC3D1 SAC3 domain containing 1
SOCS2 suppressor of cytokine signaling 2
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
STK11 serine/threonine kinase 11
TF transferrin