stat5b Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description signal transducer and activator of transcription 5B|The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 6777)
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Genes

28 genes co-occuring with the biological term stat5b in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
BCL2L1 BCL2-like 1
CCND1 cyclin D1
CD34 CD34 molecule
CD80 CD80 molecule
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
EGF epidermal growth factor
EGFR epidermal growth factor receptor
ESR1 estrogen receptor 1
GH1 growth hormone 1
HNF4A hepatocyte nuclear factor 4, alpha
HOXA1 homeobox A1
HPSE heparanase
HSP90AA2P heat shock protein 90kDa alpha (cytosolic), class A member 2, pseudogene
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFALS insulin-like growth factor binding protein, acid labile subunit
IL2RA interleukin 2 receptor, alpha
KRAS Kirsten rat sarcoma viral oncogene homolog
LCK LCK proto-oncogene, Src family tyrosine kinase
MIR134 microRNA 134
PPARG peroxisome proliferator-activated receptor gamma
PTK6 protein tyrosine kinase 6
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1
ZFP36L1 ZFP36 ring finger protein-like 1