stat6 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description signal transducer and activator of transcription 6, interleukin-4 induced|The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010] (NCBI Entrez Gene Database, 6778)
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Genes

84 genes co-occuring with the biological term stat6 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ADAM33 ADAM metallopeptidase domain 33
ALOX15 arachidonate 15-lipoxygenase
ANXA2 annexin A2
BCL2L1 BCL2-like 1
BIRC5 baculoviral IAP repeat containing 5
C1QC complement component 1, q subcomponent, C chain
C6ORF25 chromosome 6 open reading frame 25
CCL11 chemokine (C-C motif) ligand 11
CCL17 chemokine (C-C motif) ligand 17
CCL26 chemokine (C-C motif) ligand 26
CD40LG CD40 ligand
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CXCL8 chemokine (C-X-C motif) ligand 8
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DUOX1 dual oxidase 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FOXP3 forkhead box P3
GATA3 GATA binding protein 3
HDAC1 histone deacetylase 1
HNF1A HNF1 homeobox A
HRH4 histamine receptor H4
IFNA1 interferon, alpha 1
IL13 interleukin 13
IL13RA1 interleukin 13 receptor, alpha 1
IL1RN interleukin 1 receptor antagonist
IL31 interleukin 31
IL4 interleukin 4
IL4R interleukin 4 receptor
IL6 interleukin 6
IL6ST interleukin 6 signal transducer
IRF4 interferon regulatory factor 4
IRF5 interferon regulatory factor 5
IRF9 interferon regulatory factor 9
IRS2 insulin receptor substrate 2
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
JAK1 Janus kinase 1
JAK2 Janus kinase 2
JAK3 Janus kinase 3
LRP1 low density lipoprotein receptor-related protein 1
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK8 mitogen-activated protein kinase 8
MBP myelin basic protein
MIR361 microRNA 361
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2)
NCOA1 nuclear receptor coactivator 1
NCOA2 nuclear receptor coactivator 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
ORMDL3 ORMDL sphingolipid biosynthesis regulator 3
PGR progesterone receptor
PIGR polymeric immunoglobulin receptor
PPAP2A phosphatidic acid phosphatase type 2A
PPARG peroxisome proliferator-activated receptor gamma
PTGES prostaglandin E synthase
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RHOA ras homolog family member A
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SFPQ splicing factor proline/glutamine-rich
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLC26A4 solute carrier family 26 (anion exchanger), member 4
SND1 staphylococcal nuclease and tudor domain containing 1
SOCS1 suppressor of cytokine signaling 1
SOCS3 suppressor of cytokine signaling 3
SP1 Sp1 transcription factor
SPDEF SAM pointed domain containing ETS transcription factor
SPI1 Spi-1 proto-oncogene
SPIC Spi-C transcription factor (Spi-1/PU.1 related)
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT2 signal transducer and activator of transcription 2, 113kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT4 signal transducer and activator of transcription 4
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
TAC1 tachykinin, precursor 1
TBXA2R thromboxane A2 receptor
TFF3 trefoil factor 3 (intestinal)
TNF tumor necrosis factor
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b