steatohepatitis Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description Inflammation of the liver related to lipid accumulation in fatty liver.|Lipid infiltration of the hepatic parenchymal cells resulting in a yellow-colored liver. The abnormal lipid accumulation is usually in the form of TRIGLYCERIDES, either as a single large droplet or multiple small droplets. Fatty liver is caused by an imbalance in the metabolism of FATTY ACIDS. (Experimental Factor Ontology, EFO_0003934)
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Genes

67 genes co-occuring with the biological term steatohepatitis in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABHD5 abhydrolase domain containing 5
ADIPOQ adiponectin, C1Q and collagen domain containing
ADIPOR1 adiponectin receptor 1
ADIPOR2 adiponectin receptor 2
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AHSG alpha-2-HS-glycoprotein
APOC3 apolipoprotein C-III
APOE apolipoprotein E
BBC3 BCL2 binding component 3
BCL2 B-cell CLL/lymphoma 2
CD36 CD36 molecule (thrombospondin receptor)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHUK conserved helix-loop-helix ubiquitous kinase
CPB2 carboxypeptidase B2 (plasma)
CRP C-reactive protein, pentraxin-related
CXCL8 chemokine (C-X-C motif) ligand 8
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
ELOVL6 ELOVL fatty acid elongase 6
ESR1 estrogen receptor 1
FABP1 fatty acid binding protein 1, liver
FAS Fas cell surface death receptor
FOXO1 forkhead box O1
GCG glucagon
GLP1R glucagon-like peptide 1 receptor
GOT1 glutamic-oxaloacetic transaminase 1, soluble
GPT glutamic-pyruvate transaminase (alanine aminotransferase)
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
HFE hemochromatosis
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
ICAM1 intercellular adhesion molecule 1
IL10 interleukin 10
IL13RA2 interleukin 13 receptor, alpha 2
IL1RN interleukin 1 receptor antagonist
IL6 interleukin 6
INS insulin
KRT18 keratin 18, type I
LEP leptin
MAPK8 mitogen-activated protein kinase 8
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
MT-ND6 NADH dehydrogenase, subunit 6 (complex I)
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTTP microsomal triglyceride transfer protein
NCAN neurocan
NFE2L2 nuclear factor, erythroid 2-like 2
NNMT nicotinamide N-methyltransferase
NOTCH1 notch 1
NR1H4 nuclear receptor subfamily 1, group H, member 4
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
PEMT phosphatidylethanolamine N-methyltransferase
PEPD peptidase D
PNPLA3 patatin-like phospholipase domain containing 3
PPARG peroxisome proliferator-activated receptor gamma
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2
SOD2 superoxide dismutase 2, mitochondrial
TGFB1 transforming growth factor, beta 1
TIMP1 TIMP metallopeptidase inhibitor 1
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TM6SF2 transmembrane 6 superfamily member 2
TNF tumor necrosis factor
XBP1 X-box binding protein 1