sulfadiazine-5523 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the sulfadiazine-5523 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABI2 abl-interactor 2
ACTN2 actinin, alpha 2
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
AKAP7 A kinase (PRKA) anchor protein 7
ANTXR1 anthrax toxin receptor 1
APOBEC2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
ARL4C ADP-ribosylation factor-like 4C
ATAD5 ATPase family, AAA domain containing 5
ATF7IP activating transcription factor 7 interacting protein
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
BEGAIN brain-enriched guanylate kinase-associated
C11ORF63 chromosome 11 open reading frame 63
C19ORF66 chromosome 19 open reading frame 66
CADM4 cell adhesion molecule 4
CCR1 chemokine (C-C motif) receptor 1
CDKL3 cyclin-dependent kinase-like 3
CEP164 centrosomal protein 164kDa
CSN2 casein beta
DCN decorin
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DKK3 dickkopf WNT signaling pathway inhibitor 3
E2F5 E2F transcription factor 5, p130-binding
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
EXOSC1 exosome component 1
FAM13C family with sequence similarity 13, member C
FHL1 four and a half LIM domains 1
FLT4 fms-related tyrosine kinase 4
FRMD4B FERM domain containing 4B
FZD10 frizzled class receptor 10
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GPC3 glypican 3
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2
HMGA1 high mobility group AT-hook 1
HPGDS hematopoietic prostaglandin D synthase
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IKZF1 IKAROS family zinc finger 1 (Ikaros)
ISL1 ISL LIM homeobox 1
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KAT8 K(lysine) acetyltransferase 8
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2
KIAA0754 KIAA0754
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KRT17 keratin 17, type I
LAIR1 leukocyte-associated immunoglobulin-like receptor 1
LAIR2 leukocyte-associated immunoglobulin-like receptor 2
LAMA2 laminin, alpha 2
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1
LLGL1 lethal giant larvae homolog 1 (Drosophila)
LTC4S leukotriene C4 synthase
MAN1A2 mannosidase, alpha, class 1A, member 2
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
NCALD neurocalcin delta
NCF4 neutrophil cytosolic factor 4, 40kDa
NMBR neuromedin B receptor
OGFOD2 2-oxoglutarate and iron-dependent oxygenase domain containing 2
OLFM1 olfactomedin 1
OR1D2 olfactory receptor, family 1, subfamily D, member 2
PARK2 parkin RBR E3 ubiquitin protein ligase
PARVB parvin, beta
PCDHGA10 protocadherin gamma subfamily A, 10
PHC1 polyhomeotic homolog 1 (Drosophila)
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PKNOX2 PBX/knotted 1 homeobox 2
PLEKHO2 pleckstrin homology domain containing, family O member 2
PNPLA6 patatin-like phospholipase domain containing 6
POLL polymerase (DNA directed), lambda
PRB1 proline-rich protein BstNI subfamily 1
PRKCH protein kinase C, eta
PTRF polymerase I and transcript release factor
RUFY3 RUN and FYVE domain containing 3
SCN10A sodium channel, voltage gated, type X alpha subunit
SCNN1G sodium channel, non voltage gated 1 gamma subunit
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
SIPA1L1 signal-induced proliferation-associated 1 like 1
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SMAD4 SMAD family member 4
SPDEF SAM pointed domain containing ETS transcription factor
SPINK5 serine peptidase inhibitor, Kazal type 5
SPTBN5 spectrin, beta, non-erythrocytic 5
STX7 syntaxin 7
SYT5 synaptotagmin V
TBL2 transducin (beta)-like 2
TCP11L1 t-complex 11, testis-specific-like 1
TMEM63A transmembrane protein 63A
TNFRSF9 tumor necrosis factor receptor superfamily, member 9
TOP3B topoisomerase (DNA) III beta
TPMT thiopurine S-methyltransferase
TTC28 tetratricopeptide repeat domain 28
VEGFB vascular endothelial growth factor B
VWA5A von Willebrand factor A domain containing 5A
WNT10B wingless-type MMTV integration site family, member 10B
ZC3H7B zinc finger CCCH-type containing 7B
ZYX zyxin

decreased expression

Symbol Name
ALG12 ALG12, alpha-1,6-mannosyltransferase
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
BIRC7 baculoviral IAP repeat containing 7
C17ORF70 chromosome 17 open reading frame 70
CBX4 chromobox homolog 4
CCBL1 cysteine conjugate-beta lyase, cytoplasmic
CCDC85C coiled-coil domain containing 85C
CCNL2 cyclin L2
CRADD CASP2 and RIPK1 domain containing adaptor with death domain
CTNND2 catenin (cadherin-associated protein), delta 2
DHRS3 dehydrogenase/reductase (SDR family) member 3
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
ELSPBP1 epididymal sperm binding protein 1
ERN2 endoplasmic reticulum to nucleus signaling 2
FBXL15 F-box and leucine-rich repeat protein 15
FKBPL FK506 binding protein like
FLRT3 fibronectin leucine rich transmembrane protein 3
FPGS folylpolyglutamate synthase
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
H2AFJ H2A histone family, member J
HIST1H2AL histone cluster 1, H2al
HIST1H2BI histone cluster 1, H2bi
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1
HOOK2 hook microtubule-tethering protein 2
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1
JRKL JRK-like
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3
KCNMB3 potassium channel subfamily M regulatory beta subunit 3
KCTD7 potassium channel tetramerization domain containing 7
KLK6 kallikrein-related peptidase 6
LAMB2 laminin, beta 2 (laminin S)
LRFN3 leucine rich repeat and fibronectin type III domain containing 3
LRP2 low density lipoprotein receptor-related protein 2
LRP5 low density lipoprotein receptor-related protein 5
LRRC8E leucine rich repeat containing 8 family, member E
MAP9 microtubule-associated protein 9
MCOLN3 mucolipin 3
MINOS1P1 mitochondrial inner membrane organizing system 1 pseudogene 1
MSI1 musashi RNA-binding protein 1
MT1HL1 metallothionein 1H-like 1
MTMR12 myotubularin related protein 12
NCAPH non-SMC condensin I complex, subunit H
NPFFR1 neuropeptide FF receptor 1
NT5DC3 5'-nucleotidase domain containing 3
ODF2 outer dense fiber of sperm tails 2
PCDHA9 protocadherin alpha 9
PCNXL4 pecanex-like 4 (Drosophila)
PCSK7 proprotein convertase subtilisin/kexin type 7
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
PITX2 paired-like homeodomain 2
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PLEKHO1 pleckstrin homology domain containing, family O member 1
POMZP3 POM121 and ZP3 fusion
POR P450 (cytochrome) oxidoreductase
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2
PRSS22 protease, serine, 22
PSKH1 protein serine kinase H1
PTK6 protein tyrosine kinase 6
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RECQL4 RecQ protein-like 4
RNF122 ring finger protein 122
RNF43 ring finger protein 43
RP2 retinitis pigmentosa 2 (X-linked recessive)
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SCMH1 sex comb on midleg homolog 1 (Drosophila)
SCUBE2 signal peptide, CUB domain, EGF-like 2
SKI SKI proto-oncogene
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC46A3 solute carrier family 46, member 3
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
SSFA2 sperm specific antigen 2
SUSD4 sushi domain containing 4
SYT17 synaptotagmin XVII
TARBP1 TAR (HIV-1) RNA binding protein 1
TCTN2 tectonic family member 2
TMEM242 transmembrane protein 242
TMEM45A transmembrane protein 45A
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TOLLIP toll interacting protein
TRAF2 TNF receptor-associated factor 2
TRIP10 thyroid hormone receptor interactor 10
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TSPAN1 tetraspanin 1
TUBA3C tubulin, alpha 3c
UBXN6 UBX domain protein 6
VGF VGF nerve growth factor inducible
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
VWA1 von Willebrand factor A domain containing 1
WDR19 WD repeat domain 19
WDR62 WD repeat domain 62
ZDHHC11 zinc finger, DHHC-type containing 11
ZNF16 zinc finger protein 16
ZNF276 zinc finger protein 276
ZNF665 zinc finger protein 665
ZNF696 zinc finger protein 696