sulfadoxine-5852 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the sulfadoxine-5852 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTN2 actinin, alpha 2
ACVR1B activin A receptor, type IB
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
ADRBK2 adrenergic, beta, receptor kinase 2
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ARMC4 armadillo repeat containing 4
ARRB2 arrestin, beta 2
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ATP10A ATPase, class V, type 10A
ATPAF2 ATP synthase mitochondrial F1 complex assembly factor 2
BCL2 B-cell CLL/lymphoma 2
CCNG2 cyclin G2
CCNO cyclin O
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2
CEP68 centrosomal protein 68kDa
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
COL21A1 collagen, type XXI, alpha 1
CYLD cylindromatosis (turban tumor syndrome)
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
DBF4B DBF4 zinc finger B
DLX4 distal-less homeobox 4
EFNB3 ephrin-B3
EGR1 early growth response 1
FABP3 fatty acid binding protein 3, muscle and heart
FBXO22 F-box protein 22
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FOXG1 forkhead box G1
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
FXR2 fragile X mental retardation, autosomal homolog 2
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GABARAPL1 GABA(A) receptor-associated protein like 1
GOLGA8A golgin A8 family, member A
GPR85 G protein-coupled receptor 85
GRIK5 glutamate receptor, ionotropic, kainate 5
GRTP1 growth hormone regulated TBC protein 1
HOXA4 homeobox A4
HYAL3 hyaluronoglucosaminidase 3
IGFBP5 insulin-like growth factor binding protein 5
IL1R1 interleukin 1 receptor, type I
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KDM4C lysine (K)-specific demethylase 4C
KLHL1 kelch-like family member 1
KRIT1 KRIT1, ankyrin repeat containing
KRT6B keratin 6B, type II
LAMP1 lysosomal-associated membrane protein 1
LIME1 Lck interacting transmembrane adaptor 1
LMAN1 lectin, mannose-binding, 1
LPL lipoprotein lipase
LRRC61 leucine rich repeat containing 61
MASP2 mannan-binding lectin serine peptidase 2
MBD2 methyl-CpG binding domain protein 2
MBIP MAP3K12 binding inhibitory protein 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MED31 mediator complex subunit 31
MERTK MER proto-oncogene, tyrosine kinase
MFAP3L microfibrillar-associated protein 3-like
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MXD3 MAX dimerization protein 3
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1)
NEK3 NIMA-related kinase 3
NELL2 NEL-like 2 (chicken)
NMT2 N-myristoyltransferase 2
OSBPL10 oxysterol binding protein-like 10
PLCD1 phospholipase C, delta 1
PON1 paraoxonase 1
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PRPF18 pre-mRNA processing factor 18
PTBP3 polypyrimidine tract binding protein 3
QKI QKI, KH domain containing, RNA binding
RAD54B RAD54 homolog B (S. cerevisiae)
RIMBP2 RIMS binding protein 2
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
RUSC2 RUN and SH3 domain containing 2
SAMD9 sterile alpha motif domain containing 9
SENP5 SUMO1/sentrin specific peptidase 5
SIRT5 sirtuin 5
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC22A14 solute carrier family 22, member 14
SLC48A1 solute carrier family 48 (heme transporter), member 1
SMAD4 SMAD family member 4
SOGA1 suppressor of glucose, autophagy associated 1
SOS2 son of sevenless homolog 2 (Drosophila)
SPTBN1 spectrin, beta, non-erythrocytic 1
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
TBC1D17 TBC1 domain family, member 17
TCF3 transcription factor 3
TESPA1 thymocyte expressed, positive selection associated 1
TPR translocated promoter region, nuclear basket protein
TUBA8 tubulin, alpha 8
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)
VCAN versican
WIPF1 WAS/WASL interacting protein family, member 1
WIZ widely interspaced zinc finger motifs
YIPF4 Yip1 domain family, member 4
YY1 YY1 transcription factor
ZNF227 zinc finger protein 227
ZNF467 zinc finger protein 467
ZNF573 zinc finger protein 573

decreased expression

Symbol Name
ALG12 ALG12, alpha-1,6-mannosyltransferase
ANAPC2 anaphase promoting complex subunit 2
ANKZF1 ankyrin repeat and zinc finger domain containing 1
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5
ATP10D ATPase, class V, type 10D
BAK1 BCL2-antagonist/killer 1
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BEX1 brain expressed, X-linked 1
C11ORF80 chromosome 11 open reading frame 80
C5ORF45 chromosome 5 open reading frame 45
CAPN5 calpain 5
CCDC130 coiled-coil domain containing 130
CCS copper chaperone for superoxide dismutase
CDKL3 cyclin-dependent kinase-like 3
CEP85 centrosomal protein 85kDa
CFAP69 cilia and flagella associated protein 69
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal)
CMTR1 cap methyltransferase 1
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
DCLRE1B DNA cross-link repair 1B
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
EAF2 ELL associated factor 2
ERMAP erythroblast membrane-associated protein (Scianna blood group)
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM160B2 family with sequence similarity 160, member B2
FBRS fibrosin
FBXL2 F-box and leucine-rich repeat protein 2
FBXW12 F-box and WD repeat domain containing 12
GID4 GID complex subunit 4
GMIP GEM interacting protein
GNG4 guanine nucleotide binding protein (G protein), gamma 4
HAMP hepcidin antimicrobial peptide
HIST1H2AE histone cluster 1, H2ae
HOXA1 homeobox A1
HOXB13 homeobox B13
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1
INPPL1 inositol polyphosphate phosphatase-like 1
IREB2 iron-responsive element binding protein 2
IRF1 interferon regulatory factor 1
ITPKC inositol-trisphosphate 3-kinase C
KIAA0232 KIAA0232
KLF7 Kruppel-like factor 7 (ubiquitous)
KRT31 keratin 31, type I
KRT75 keratin 75, type II
LOC100286895 cell division cycle 27 homolog pseudogene
LPAR3 lysophosphatidic acid receptor 3
LSR lipolysis stimulated lipoprotein receptor
LZTR1 leucine-zipper-like transcription regulator 1
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast)
MAST3 microtubule associated serine/threonine kinase 3
MED22 mediator complex subunit 22
MVP major vault protein
NARFL nuclear prelamin A recognition factor-like
NDE1 nudE neurodevelopment protein 1
NINL ninein-like
NMRK1 nicotinamide riboside kinase 1
NPM3 nucleophosmin/nucleoplasmin 3
NRSN2 neurensin 2
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor
OPLAH 5-oxoprolinase (ATP-hydrolysing)
PAQR6 progestin and adipoQ receptor family member VI
PARD6A par-6 family cell polarity regulator alpha
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PHGDH phosphoglycerate dehydrogenase
PHKG2 phosphorylase kinase, gamma 2 (testis)
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
POMT1 protein-O-mannosyltransferase 1
PRMT7 protein arginine methyltransferase 7
RIC8B RIC8 guanine nucleotide exchange factor B
RNF122 ring finger protein 122
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SERTAD3 SERTA domain containing 3
SLC39A1 solute carrier family 39 (zinc transporter), member 1
SND1-IT1 SND1 intronic transcript 1
SOX12 SRY (sex determining region Y)-box 12
SPAG4 sperm associated antigen 4
SYNPO synaptopodin
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TARBP1 TAR (HIV-1) RNA binding protein 1
TBC1D19 TBC1 domain family, member 19
TCTN1 tectonic family member 1
TMC5 transmembrane channel-like 5
TMEM183A transmembrane protein 183A
TRAPPC6A trafficking protein particle complex 6A
TRIM66 tripartite motif containing 66
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TTC23 tetratricopeptide repeat domain 23
USB1 U6 snRNA biogenesis 1
USP20 ubiquitin specific peptidase 20
WNT10B wingless-type MMTV integration site family, member 10B
ZNF10 zinc finger protein 10
ZNF426 zinc finger protein 426
ZNF668 zinc finger protein 668