sulfamethoxazole-2335 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the sulfamethoxazole-2335 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACOX1 acyl-CoA oxidase 1, palmitoyl
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
ARID5A AT rich interactive domain 5A (MRF1-like)
BRCA2 breast cancer 2, early onset
C14ORF93 chromosome 14 open reading frame 93
C21ORF91 chromosome 21 open reading frame 91
C5 complement component 5
C5ORF45 chromosome 5 open reading frame 45
CABP2 calcium binding protein 2
CAV2 caveolin 2
CCKAR cholecystokinin A receptor
CCNG2 cyclin G2
CEP162 centrosomal protein 162kDa
CEP170B centrosomal protein 170B
CHML choroideremia-like (Rab escort protein 2)
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
CRHR2 corticotropin releasing hormone receptor 2
CRTC1 CREB regulated transcription coactivator 1
CTNND1 catenin (cadherin-associated protein), delta 1
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DLK2 delta-like 2 homolog (Drosophila)
DNASE2 deoxyribonuclease II, lysosomal
DNM3 dynamin 3
DXO decapping exoribonuclease
ENOX2 ecto-NOX disulfide-thiol exchanger 2
ESR1 estrogen receptor 1
EXPH5 exophilin 5
FAM63A family with sequence similarity 63, member A
FBXL18 F-box and leucine-rich repeat protein 18
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FERMT1 fermitin family member 1
FOXG1 forkhead box G1
FXYD2 FXYD domain containing ion transport regulator 2
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10
GPR137 G protein-coupled receptor 137
GPR153 G protein-coupled receptor 153
HOPX HOP homeobox
ICOSLG inducible T-cell co-stimulator ligand
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KCTD13 potassium channel tetramerization domain containing 13
KIF1B kinesin family member 1B
KMT2A lysine (K)-specific methyltransferase 2A
LARP7 La ribonucleoprotein domain family, member 7
LIMD2 LIM domain containing 2
LOXL2 lysyl oxidase-like 2
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAPT microtubule-associated protein tau
MARK4 MAP/microtubule affinity-regulating kinase 4
MBTPS2 membrane-bound transcription factor peptidase, site 2
MED28 mediator complex subunit 28
MKL1 megakaryoblastic leukemia (translocation) 1
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MMRN2 multimerin 2
MOBP myelin-associated oligodendrocyte basic protein
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MVK mevalonate kinase
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle
NDRG2 NDRG family member 2
NEB nebulin
NELL2 NEL-like 2 (chicken)
NOL12 nucleolar protein 12
NUDCD3 NudC domain containing 3
PDE12 phosphodiesterase 12
PDE4DIP phosphodiesterase 4D interacting protein
PIAS3 protein inhibitor of activated STAT, 3
PLK2 polo-like kinase 2
PLSCR3 phospholipid scramblase 3
PSG4 pregnancy specific beta-1-glycoprotein 4
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RBM19 RNA binding motif protein 19
RNF19B ring finger protein 19B
SCARB2 scavenger receptor class B, member 2
SIPA1L1 signal-induced proliferation-associated 1 like 1
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7
SMAD5 SMAD family member 5
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SNX13 sorting nexin 13
SPHK2 sphingosine kinase 2
SPON1 spondin 1, extracellular matrix protein
STBD1 starch binding domain 1
SYNJ2 synaptojanin 2
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TAPBPL TAP binding protein-like
TBCD tubulin folding cofactor D
TJAP1 tight junction associated protein 1 (peripheral)
TLN2 talin 2
TMEM242 transmembrane protein 242
TOP3A topoisomerase (DNA) III alpha
TPBG trophoblast glycoprotein
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VN1R1 vomeronasal 1 receptor 1
WNK1 WNK lysine deficient protein kinase 1
ZBTB22 zinc finger and BTB domain containing 22
ZNF354A zinc finger protein 354A
ZNF43 zinc finger protein 43
ZNF696 zinc finger protein 696

decreased expression

Symbol Name
ACPP acid phosphatase, prostate
ANKRD36 ankyrin repeat domain 36
APOBR apolipoprotein B receptor
ASB8 ankyrin repeat and SOCS box containing 8
ATAD3A ATPase family, AAA domain containing 3A
ATG2B autophagy related 2B
ATG9A autophagy related 9A
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
BCL2L2 BCL2-like 2
BOLA1 bolA family member 1
C11ORF71 chromosome 11 open reading frame 71
C19ORF40 chromosome 19 open reading frame 40
C19ORF66 chromosome 19 open reading frame 66
C3 complement component 3
C7ORF69 chromosome 7 open reading frame 69
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCDC85C coiled-coil domain containing 85C
CD1D CD1d molecule
CHMP1A charged multivesicular body protein 1A
CLCF1 cardiotrophin-like cytokine factor 1
CLCN6 chloride channel, voltage-sensitive 6
CLEC7A C-type lectin domain family 7, member A
CLSTN1 calsyntenin 1
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
CX3CR1 chemokine (C-X3-C motif) receptor 1
DEPTOR DEP domain containing MTOR-interacting protein
DHRS11 dehydrogenase/reductase (SDR family) member 11
DSPP dentin sialophosphoprotein
DUSP5 dual specificity phosphatase 5
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
ELP6 elongator acetyltransferase complex subunit 6
ERF Ets2 repressor factor
ERN2 endoplasmic reticulum to nucleus signaling 2
FBXL6 F-box and leucine-rich repeat protein 6
FLJ21369 uncharacterized protein FLJ21369
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor 1
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GNL1 guanine nucleotide binding protein-like 1
HIST1H1E histone cluster 1, H1e
HOOK2 hook microtubule-tethering protein 2
HP haptoglobin
HS1BP3 HCLS1 binding protein 3
IL2RG interleukin 2 receptor, gamma
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase
ITPKB inositol-trisphosphate 3-kinase B
KLHL21 kelch-like family member 21
KLK5 kallikrein-related peptidase 5
LRRC20 leucine rich repeat containing 20
LSP1 lymphocyte-specific protein 1
MANBA mannosidase, beta A, lysosomal
MBNL3 muscleblind-like splicing regulator 3
MED22 mediator complex subunit 22
METTL2B methyltransferase like 2B
NAG18 NAG18 mRNA
NHEJ1 nonhomologous end-joining factor 1
NIPAL2 NIPA-like domain containing 2
NPFFR1 neuropeptide FF receptor 1
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
PCSK7 proprotein convertase subtilisin/kexin type 7
PDZD7 PDZ domain containing 7
PPCS phosphopantothenoylcysteine synthetase
PPP6R2 protein phosphatase 6, regulatory subunit 2
PPP6R3 protein phosphatase 6, regulatory subunit 3
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit
QPCT glutaminyl-peptide cyclotransferase
QTRT1 queuine tRNA-ribosyltransferase 1
RCAN3 RCAN family member 3
RGP1 RGP1 retrograde golgi transport homolog (S. cerevisiae)
RNF167 ring finger protein 167
SDC4 syndecan 4
SIDT1 SID1 transmembrane family, member 1
SLC35C2 solute carrier family 35 (GDP-fucose transporter), member C2
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SMR3A submaxillary gland androgen regulated protein 3A
SNRPN small nuclear ribonucleoprotein polypeptide N
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2
STAG3L1 stromal antigen 3-like 1 (pseudogene)
STARD3 StAR-related lipid transfer (START) domain containing 3
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TCTA T-cell leukemia translocation altered
THG1L tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)
TM7SF2 transmembrane 7 superfamily member 2
TMEM212 transmembrane protein 212
UGDH UDP-glucose 6-dehydrogenase
USP19 ubiquitin specific peptidase 19
VNN2 vanin 2
VPS8 vacuolar protein sorting 8 homolog (S. cerevisiae)
WDR62 WD repeat domain 62
XPC xeroderma pigmentosum, complementation group C
XYLT2 xylosyltransferase II
ZBED8 zinc finger, BED-type containing 8
ZDHHC18 zinc finger, DHHC-type containing 18
ZNF480 zinc finger protein 480
ZNF506 zinc finger protein 506
ZNHIT2 zinc finger, HIT-type containing 2
ZSCAN16 zinc finger and SCAN domain containing 16