sulfamethoxazole-4690 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the sulfamethoxazole-4690 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACOT11 acyl-CoA thioesterase 11
ADGRG2 adhesion G protein-coupled receptor G2
AGFG2 ArfGAP with FG repeats 2
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
AMBP alpha-1-microglobulin/bikunin precursor
ANP32A-IT1 ANP32A intronic transcript 1
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ATM ATM serine/threonine kinase
BHLHE40 basic helix-loop-helix family, member e40
BMP5 bone morphogenetic protein 5
BMP8B bone morphogenetic protein 8b
C10ORF95 chromosome 10 open reading frame 95
C17ORF59 chromosome 17 open reading frame 59
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CD58 CD58 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
DIXDC1 DIX domain containing 1
DLC1 DLC1 Rho GTPase activating protein
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
EN2 engrailed homeobox 2
F12 coagulation factor XII (Hageman factor)
FBXO11 F-box protein 11
FGF13 fibroblast growth factor 13
FLCN folliculin
FLOT1 flotillin 1
FRMD4A FERM domain containing 4A
FUS FUS RNA binding protein
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GALC galactosylceramidase
GAS7 growth arrest-specific 7
GFI1 growth factor independent 1 transcription repressor
GINS4 GINS complex subunit 4 (Sld5 homolog)
GLB1L galactosidase, beta 1-like
GPR143 G protein-coupled receptor 143
GULP1 GULP, engulfment adaptor PTB domain containing 1
GUSBP3 glucuronidase, beta pseudogene 3
HFE hemochromatosis
HOXB2 homeobox B2
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPG2 heparan sulfate proteoglycan 2
ICA1 islet cell autoantigen 1, 69kDa
IFT54 intraflagellar transport 54
KAZALD1 Kazal-type serine peptidase inhibitor domain 1
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
LAT2 linker for activation of T cells family, member 2
LRRC37A3 leucine rich repeat containing 37, member A3
MAP2K5 mitogen-activated protein kinase kinase 5
MEGF8 multiple EGF-like-domains 8
MUC1 mucin 1, cell surface associated
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
PBOV1 prostate and breast cancer overexpressed 1
PER1 period circadian clock 1
PHLDB1 pleckstrin homology-like domain, family B, member 1
PLEK pleckstrin
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PSG6 pregnancy specific beta-1-glycoprotein 6
QKI QKI, KH domain containing, RNA binding
QSER1 glutamine and serine rich 1
RAB6A RAB6A, member RAS oncogene family
RAI2 retinoic acid induced 2
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RASAL2 RAS protein activator like 2
RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae)
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RNGTT RNA guanylyltransferase and 5'-phosphatase
ROM1 retinal outer segment membrane protein 1
RPH3AL rabphilin 3A-like (without C2 domains)
RPL10L ribosomal protein L10-like
SCG2 secretogranin II
SCN10A sodium channel, voltage gated, type X alpha subunit
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2
SORT1 sortilin 1
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPRED2 sprouty-related, EVH1 domain containing 2
SRSF7 serine/arginine-rich splicing factor 7
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4
STATH statherin
TLR2 toll-like receptor 2
TPMT thiopurine S-methyltransferase
VDAC3 voltage-dependent anion channel 3
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
ZCCHC4 zinc finger, CCHC domain containing 4
ZDHHC11 zinc finger, DHHC-type containing 11
ZIC3 Zic family member 3
ZNF222 zinc finger protein 222
ZNF473 zinc finger protein 473
ZNF606 zinc finger protein 606
ZNF652 zinc finger protein 652
ZNF76 zinc finger protein 76

decreased expression

Symbol Name
ACSL4 acyl-CoA synthetase long-chain family member 4
AKT2 v-akt murine thymoma viral oncogene homolog 2
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
ATPAF2 ATP synthase mitochondrial F1 complex assembly factor 2
BFSP1 beaded filament structural protein 1, filensin
C2ORF54 chromosome 2 open reading frame 54
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CAMK1 calcium/calmodulin-dependent protein kinase I
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CD79A CD79a molecule, immunoglobulin-associated alpha
CLCN6 chloride channel, voltage-sensitive 6
CLIC2 chloride intracellular channel 2
CNR2 cannabinoid receptor 2 (macrophage)
DNALI1 dynein, axonemal, light intermediate chain 1
DOC2A double C2-like domains, alpha
DSPP dentin sialophosphoprotein
ERN2 endoplasmic reticulum to nucleus signaling 2
ETAA1 Ewing tumor-associated antigen 1
FAM131A family with sequence similarity 131, member A
FAM155A family with sequence similarity 155, member A
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FLJ21369 uncharacterized protein FLJ21369
FLJ22184
FSTL3 follistatin-like 3 (secreted glycoprotein)
FURIN furin (paired basic amino acid cleaving enzyme)
GEMIN8 gem (nuclear organelle) associated protein 8
GLRA1 glycine receptor, alpha 1
GPC3 glypican 3
HIST1H1D histone cluster 1, H1d
HIST1H2BN histone cluster 1, H2bn
HIST2H2AA3 histone cluster 2, H2aa3
HOXA4 homeobox A4
HOXC8 homeobox C8
HSPB6 heat shock protein, alpha-crystallin-related, B6
IL12RB1 interleukin 12 receptor, beta 1
IPO8 importin 8
KCTD20 potassium channel tetramerization domain containing 20
KIF13A kinesin family member 13A
KLF13 Kruppel-like factor 13
KLHL25 kelch-like family member 25
KPNA5 karyopherin alpha 5 (importin alpha 6)
KRT31 keratin 31, type I
LOC202181 SUMO-interacting motifs containing 1 pseudogene
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MBL1P mannose-binding lectin (protein A) 1, pseudogene
MBNL3 muscleblind-like splicing regulator 3
MGC12488
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MYL5 myosin, light chain 5, regulatory
NAG18 NAG18 mRNA
NIPAL2 NIPA-like domain containing 2
NPM3 nucleophosmin/nucleoplasmin 3
NT5E 5'-nucleotidase, ecto (CD73)
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
OVGP1 oviductal glycoprotein 1, 120kDa
PDE12 phosphodiesterase 12
PMEL premelanosome protein
POLH polymerase (DNA directed), eta
PRB3 proline-rich protein BstNI subfamily 3
PRF1 perforin 1 (pore forming protein)
PRR4 proline rich 4 (lacrimal)
PRSS53 protease, serine, 53
PTPRS protein tyrosine phosphatase, receptor type, S
QPCT glutaminyl-peptide cyclotransferase
RAB3A RAB3A, member RAS oncogene family
RAB3D RAB3D, member RAS oncogene family
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS20 regulator of G-protein signaling 20
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RPGRIP1L RPGRIP1-like
SAA3P serum amyloid A3 pseudogene
SAMD9 sterile alpha motif domain containing 9
SCYL2 SCY1-like 2 (S. cerevisiae)
SKI SKI proto-oncogene
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22
SLC44A1 solute carrier family 44 (choline transporter), member 1
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SP1 Sp1 transcription factor
STK16 serine/threonine kinase 16
STMN3 stathmin-like 3
TIGD6 tigger transposable element derived 6
TMEM120B transmembrane protein 120B
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNRC6B trinucleotide repeat containing 6B
TRNAU1AP tRNA selenocysteine 1 associated protein 1
TSPAN1 tetraspanin 1
TUBB2B tubulin, beta 2B class IIb
UBE2L6 ubiquitin-conjugating enzyme E2L 6
UPP1 uridine phosphorylase 1
VIM vimentin
WDR91 WD repeat domain 91
ZBTB22 zinc finger and BTB domain containing 22
ZNF141 zinc finger protein 141
ZNF329 zinc finger protein 329