sulfamethoxypyridazine-2550 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the sulfamethoxypyridazine-2550 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACRV1 acrosomal vesicle protein 1
ANGPTL2 angiopoietin-like 2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
AP1M2 adaptor-related protein complex 1, mu 2 subunit
BBS9 Bardet-Biedl syndrome 9
BCAS4 breast carcinoma amplified sequence 4
BCL2 B-cell CLL/lymphoma 2
BCL2L10 BCL2-like 10 (apoptosis facilitator)
BDKRB1 bradykinin receptor B1
BTD biotinidase
CA3 carbonic anhydrase III
CAND2 cullin-associated and neddylation-dissociated 2 (putative)
CAPN9 calpain 9
CD160 CD160 molecule
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
COL6A3 collagen, type VI, alpha 3
CRABP2 cellular retinoic acid binding protein 2
CRTC1 CREB regulated transcription coactivator 1
CTNND1 catenin (cadherin-associated protein), delta 1
CTNND2 catenin (cadherin-associated protein), delta 2
CYTH1 cytohesin 1
DCN decorin
DDR1-AS1 DDR1 antisense RNA 1 (head to head)
DRD2 dopamine receptor D2
EDRF1 erythroid differentiation regulatory factor 1
EGR4 early growth response 4
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EPYC epiphycan
F7 coagulation factor VII (serum prothrombin conversion accelerator)
FCAR Fc fragment of IgA receptor
FLRT1 fibronectin leucine rich transmembrane protein 1
FUS FUS RNA binding protein
FYB FYN binding protein
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
GP2 glycoprotein 2 (zymogen granule membrane)
GPC1 glypican 1
GPR132 G protein-coupled receptor 132
GPR135 G protein-coupled receptor 135
GRHL2 grainyhead-like 2 (Drosophila)
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
HTR7P1 5-hydroxytryptamine (serotonin) receptor 7 pseudogene 1
IGFBP5 insulin-like growth factor binding protein 5
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KCTD17 potassium channel tetramerization domain containing 17
KDM8 lysine (K)-specific demethylase 8
KIR3DX1 killer cell immunoglobulin-like receptor, three domains, X1
KLHL18 kelch-like family member 18
KLK10 kallikrein-related peptidase 10
KLK13 kallikrein-related peptidase 13
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
LMF1 lipase maturation factor 1
LOC100131510 uncharacterized LOC100131510
MAPK8 mitogen-activated protein kinase 8
MLH3 mutL homolog 3
MTAP methylthioadenosine phosphorylase
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
NFE2L3 nuclear factor, erythroid 2-like 3
NPEPL1 aminopeptidase-like 1
NPHS1 nephrosis 1, congenital, Finnish type (nephrin)
OR2H2 olfactory receptor, family 2, subfamily H, member 2
PHKG1 phosphorylase kinase, gamma 1 (muscle)
PKP4 plakophilin 4
PLAC1 placenta-specific 1
PLSCR3 phospholipid scramblase 3
PPP5C protein phosphatase 5, catalytic subunit
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RAB27B RAB27B, member RAS oncogene family
RANBP17 RAN binding protein 17
RAP2B RAP2B, member of RAS oncogene family
RIMS2 regulating synaptic membrane exocytosis 2
RPL13 ribosomal protein L13
RTEL1 regulator of telomere elongation helicase 1
SCRG1 stimulator of chondrogenesis 1
SEC61A2 Sec61 alpha 2 subunit (S. cerevisiae)
SFRP4 secreted frizzled-related protein 4
SHC3 SHC (Src homology 2 domain containing) transforming protein 3
SLAMF7 SLAM family member 7
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SMAD5 SMAD family member 5
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SPRED2 sprouty-related, EVH1 domain containing 2
SPTA1 spectrin, alpha, erythrocytic 1
SRPK2 SRSF protein kinase 2
ST14 suppression of tumorigenicity 14 (colon carcinoma)
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4
SYNDIG1 synapse differentiation inducing 1
SYNM synemin, intermediate filament protein
TCP11 t-complex 11, testis-specific
TMSB15A thymosin beta 15a
TP53I11 tumor protein p53 inducible protein 11
TSPAN2 tetraspanin 2
TTC30A tetratricopeptide repeat domain 30A
TXNRD2 thioredoxin reductase 2
USP6NL USP6 N-terminal like
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
ZFP2 ZFP2 zinc finger protein

decreased expression

Symbol Name
ADGRE2 adhesion G protein-coupled receptor E2
AP1AR adaptor-related protein complex 1 associated regulatory protein
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
ARMC6 armadillo repeat containing 6
ARMC7 armadillo repeat containing 7
ASB13 ankyrin repeat and SOCS box containing 13
ASCC1 activating signal cointegrator 1 complex subunit 1
ASTE1 asteroid homolog 1 (Drosophila)
C11ORF30 chromosome 11 open reading frame 30
C1ORF159 chromosome 1 open reading frame 159
C5ORF45 chromosome 5 open reading frame 45
CA5BP1 carbonic anhydrase VB pseudogene 1
CD3D CD3d molecule, delta (CD3-TCR complex)
CD9 CD9 molecule
CDK20 cyclin-dependent kinase 20
CDK3 cyclin-dependent kinase 3
CDR2L cerebellar degeneration-related protein 2-like
CELP carboxyl ester lipase pseudogene
CFP complement factor properdin
CHML choroideremia-like (Rab escort protein 2)
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal)
CRNKL1 crooked neck pre-mRNA splicing factor 1
CSRNP2 cysteine-serine-rich nuclear protein 2
DGAT1 diacylglycerol O-acyltransferase 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERN2 endoplasmic reticulum to nucleus signaling 2
EXD3 exonuclease 3'-5' domain containing 3
FAM188A family with sequence similarity 188, member A
FGF23 fibroblast growth factor 23
FJX1 four jointed box 1 (Drosophila)
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GGTLC1 gamma-glutamyltransferase light chain 1
GPR3 G protein-coupled receptor 3
GRPR gastrin-releasing peptide receptor
HAMP hepcidin antimicrobial peptide
HIST1H1T histone cluster 1, H1t
IFT81 intraflagellar transport 81
JADE3 jade family PHD finger 3
KDM5C lysine (K)-specific demethylase 5C
KIAA0753 KIAA0753
KIAA1024 KIAA1024
LAIR2 leukocyte-associated immunoglobulin-like receptor 2
LIME1 Lck interacting transmembrane adaptor 1
LINC00339 long intergenic non-protein coding RNA 339
LNPEP leucyl/cystinyl aminopeptidase
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
LTBP3 latent transforming growth factor beta binding protein 3
LY6D lymphocyte antigen 6 complex, locus D
MANSC1 MANSC domain containing 1
MAPK12 mitogen-activated protein kinase 12
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial
MRPL44 mitochondrial ribosomal protein L44
MXD3 MAX dimerization protein 3
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NPFFR1 neuropeptide FF receptor 1
NPM3 nucleophosmin/nucleoplasmin 3
OCEL1 occludin/ELL domain containing 1
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
PCNXL4 pecanex-like 4 (Drosophila)
PDGFD platelet derived growth factor D
PELP1 proline, glutamate and leucine rich protein 1
PIGL phosphatidylinositol glycan anchor biosynthesis, class L
PITX2 paired-like homeodomain 2
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma
PLS1 plastin 1
PNMA1 paraneoplastic Ma antigen 1
PPDPF pancreatic progenitor cell differentiation and proliferation factor
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
PRSS53 protease, serine, 53
PTGIR prostaglandin I2 (prostacyclin) receptor (IP)
PWAR5 Prader Willi/Angelman region RNA 5
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RHOBTB1 Rho-related BTB domain containing 1
SCRN3 secernin 3
SLC15A3 solute carrier family 15 (oligopeptide transporter), member 3
SLC38A6 solute carrier family 38, member 6
SLC44A1 solute carrier family 44 (choline transporter), member 1
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1
SNHG20 small nucleolar RNA host gene 20
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TCTA T-cell leukemia translocation altered
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
TMEM242 transmembrane protein 242
TNRC6B trinucleotide repeat containing 6B
TRIM5 tripartite motif containing 5
TSPYL2 TSPY-like 2
UNKL unkempt family zinc finger-like
UPB1 ureidopropionase, beta
ZBTB39 zinc finger and BTB domain containing 39
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZHX2 zinc fingers and homeoboxes 2
ZNF324 zinc finger protein 324
ZNF354A zinc finger protein 354A
ZNF675 zinc finger protein 675
ZNF696 zinc finger protein 696
ZNF74 zinc finger protein 74
ZNHIT2 zinc finger, HIT-type containing 2