sulfamethoxypyridazine-3409 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the sulfamethoxypyridazine-3409 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ACPP acid phosphatase, prostate
ADARB1 adenosine deaminase, RNA-specific, B1
AKR1C1 aldo-keto reductase family 1, member C1
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ATP2A3 ATPase, Ca++ transporting, ubiquitous
BMP2K BMP2 inducible kinase
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
BTN3A1 butyrophilin, subfamily 3, member A1
C19ORF73 chromosome 19 open reading frame 73
C5 complement component 5
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CCDC57 coiled-coil domain containing 57
CCL27 chemokine (C-C motif) ligand 27
CCNK cyclin K
CDC25A cell division cycle 25A
COL8A2 collagen, type VIII, alpha 2
CRTC1 CREB regulated transcription coactivator 1
CTNS cystinosin, lysosomal cystine transporter
DIAPH1 diaphanous-related formin 1
DNAH17 dynein, axonemal, heavy chain 17
DOK2 docking protein 2, 56kDa
E2F4 E2F transcription factor 4, p107/p130-binding
EHMT2 euchromatic histone-lysine N-methyltransferase 2
ELL elongation factor RNA polymerase II
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GLRX3 glutaredoxin 3
GPATCH4 G patch domain containing 4
GRB7 growth factor receptor-bound protein 7
GREB1L growth regulation by estrogen in breast cancer-like
HAND1 heart and neural crest derivatives expressed 1
HBS1L HBS1-like translational GTPase
HYI hydroxypyruvate isomerase (putative)
IFT27 intraflagellar transport 27
INCENP inner centromere protein antigens 135/155kDa
IRF8 interferon regulatory factor 8
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KDM8 lysine (K)-specific demethylase 8
KHK ketohexokinase (fructokinase)
KITLG KIT ligand
KLHL25 kelch-like family member 25
LAMC2 laminin, gamma 2
LHX6 LIM homeobox 6
LLPH LLP homolog, long-term synaptic facilitation (Aplysia)
LMNA lamin A/C
LOC647070 uncharacterized LOC647070
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MFAP2 microfibrillar-associated protein 2
MINOS1P1 mitochondrial inner membrane organizing system 1 pseudogene 1
MITF microphthalmia-associated transcription factor
MOSPD3 motile sperm domain containing 3
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MUC3B mucin 3B, cell surface associated
MXD3 MAX dimerization protein 3
NOP16 NOP16 nucleolar protein
NUMA1 nuclear mitotic apparatus protein 1
OGFOD3 2-oxoglutarate and iron-dependent oxygenase domain containing 3
ONECUT2 one cut homeobox 2
OR12D2 olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene)
PACS1 phosphofurin acidic cluster sorting protein 1
PCDHA6 protocadherin alpha 6
PDE1B phosphodiesterase 1B, calmodulin-dependent
PECAM1 platelet/endothelial cell adhesion molecule 1
PGBD5 piggyBac transposable element derived 5
PHF3 PHD finger protein 3
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLAC1 placenta-specific 1
PLAUR plasminogen activator, urokinase receptor
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLIN2 perilipin 2
RAB3A RAB3A, member RAS oncogene family
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RNF19B ring finger protein 19B
RRAGD Ras-related GTP binding D
SCG2 secretogranin II
SETD1A SET domain containing 1A
SHANK2 SH3 and multiple ankyrin repeat domains 2
SLC22A14 solute carrier family 22, member 14
SLC35E2 solute carrier family 35, member E2
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SPINK4 serine peptidase inhibitor, Kazal type 4
STOML1 stomatin (EPB72)-like 1
SUGP1 SURP and G patch domain containing 1
SURF1 surfeit 1
TBX19 T-box 19
TMEM242 transmembrane protein 242
TRIO trio Rho guanine nucleotide exchange factor
USP48 ubiquitin specific peptidase 48
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae)
ZBTB48 zinc finger and BTB domain containing 48
ZER1 zyg-11 related, cell cycle regulator
ZFP36L1 ZFP36 ring finger protein-like 1
ZNF16 zinc finger protein 16
ZNF444 zinc finger protein 444

decreased expression

Symbol Name
AKT1 v-akt murine thymoma viral oncogene homolog 1
AMBRA1 autophagy/beclin-1 regulator 1
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ANKRD28 ankyrin repeat domain 28
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1
AXIN1 axin 1
BTF3P12 basic transcription factor 3 pseudogene 12
C7ORF43 chromosome 7 open reading frame 43
C9ORF40 chromosome 9 open reading frame 40
CCDC94 coiled-coil domain containing 94
CEP85 centrosomal protein 85kDa
CEP97 centrosomal protein 97kDa
CHKB choline kinase beta
CHST10 carbohydrate sulfotransferase 10
CLK1 CDC-like kinase 1
CNPY3 canopy FGF signaling regulator 3
CPSF7 cleavage and polyadenylation specific factor 7, 59kDa
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
EIF5A2 eukaryotic translation initiation factor 5A2
EPB41L5 erythrocyte membrane protein band 4.1 like 5
ERCC4 excision repair cross-complementation group 4
ERO1L ERO1-like (S. cerevisiae)
EXOC3 exocyst complex component 3
EYA2 EYA transcriptional coactivator and phosphatase 2
F3 coagulation factor III (thromboplastin, tissue factor)
FAM114A1 family with sequence similarity 114, member A1
FAM192A family with sequence similarity 192, member A
FANCE Fanconi anemia, complementation group E
FZD4 frizzled class receptor 4
GINS4 GINS complex subunit 4 (Sld5 homolog)
GLS2 glutaminase 2 (liver, mitochondrial)
GLTSCR1 glioma tumor suppressor candidate region gene 1
GNL1 guanine nucleotide binding protein-like 1
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
HIRA histone cell cycle regulator
HIST1H2AJ histone cluster 1, H2aj
HPS6 Hermansky-Pudlak syndrome 6
HYAL2 hyaluronoglucosaminidase 2
IGSF1 immunoglobulin superfamily, member 1
INF2 inverted formin, FH2 and WH2 domain containing
KREMEN2 kringle containing transmembrane protein 2
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LOC257152 uncharacterized LOC257152
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LRP5 low density lipoprotein receptor-related protein 5
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
LYPLA2P1 lysophospholipase II pseudogene 1
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MGC12488
NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
NBEAL2 neurobeachin-like 2
NPY5R neuropeptide Y receptor Y5
NT5DC3 5'-nucleotidase domain containing 3
NUBPL nucleotide binding protein-like
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
PEX26 peroxisomal biogenesis factor 26
PGP phosphoglycolate phosphatase
PGPEP1 pyroglutamyl-peptidase I
PHC1 polyhomeotic homolog 1 (Drosophila)
PPT2 palmitoyl-protein thioesterase 2
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2
QTRT1 queuine tRNA-ribosyltransferase 1
RBM38 RNA binding motif protein 38
REEP4 receptor accessory protein 4
SAYSD1 SAYSVFN motif domain containing 1
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC4A1AP solute carrier family 4 (anion exchanger), member 1, adaptor protein
SOWAHC sosondowah ankyrin repeat domain family member C
SPATA7 spermatogenesis associated 7
SRD5A3 steroid 5 alpha-reductase 3
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2
SSBP3 single stranded DNA binding protein 3
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1
STK25 serine/threonine kinase 25
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast)
TMEM39B transmembrane protein 39B
TNS2 tensin 2
TRABD TraB domain containing
TRIM5 tripartite motif containing 5
TRIM66 tripartite motif containing 66
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae)
VWA1 von Willebrand factor A domain containing 1
WDR76 WD repeat domain 76
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
YEATS2 YEATS domain containing 2
ZC3H12A zinc finger CCCH-type containing 12A
ZNF134 zinc finger protein 134
ZNF248 zinc finger protein 248
ZNF652 zinc finger protein 652
ZNF675 zinc finger protein 675