sulfamethoxypyridazine-3609 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the sulfamethoxypyridazine-3609 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACSBG1 acyl-CoA synthetase bubblegum family member 1
ADAM7 ADAM metallopeptidase domain 7
AGXT alanine-glyoxylate aminotransferase
AHCYL1 adenosylhomocysteinase-like 1
BMPR1B bone morphogenetic protein receptor, type IB
BTN2A2 butyrophilin, subfamily 2, member A2
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CALCRL calcitonin receptor-like
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CCL23 chemokine (C-C motif) ligand 23
CCR9 chemokine (C-C motif) receptor 9
CD6 CD6 molecule
CLCF1 cardiotrophin-like cytokine factor 1
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
DBT dihydrolipoamide branched chain transacylase E2
DCLK2 doublecortin-like kinase 2
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DLK2 delta-like 2 homolog (Drosophila)
DMRT1 doublesex and mab-3 related transcription factor 1
DNASE1L2 deoxyribonuclease I-like 2
DRD5 dopamine receptor D5
EDN1 endothelin 1
EFHC2 EF-hand domain (C-terminal) containing 2
EFNB1 ephrin-B1
ELMO1 engulfment and cell motility 1
EN2 engrailed homeobox 2
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
FGF2 fibroblast growth factor 2 (basic)
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FLOT1 flotillin 1
FOXE1 forkhead box E1
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GAS7 growth arrest-specific 7
GFER growth factor, augmenter of liver regeneration
GPER1 G protein-coupled estrogen receptor 1
GPR20 G protein-coupled receptor 20
GRM1 glutamate receptor, metabotropic 1
GYG2 glycogenin 2
HSD17B3 hydroxysteroid (17-beta) dehydrogenase 3
ICOSLG inducible T-cell co-stimulator ligand
IFNA5 interferon, alpha 5
IGLJ3 immunoglobulin lambda joining 3
INPP5B inositol polyphosphate-5-phosphatase, 75kDa
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KLF12 Kruppel-like factor 12
KLHL29 kelch-like family member 29
KRT17 keratin 17, type I
KRT8 keratin 8, type II
L3MBTL1 l(3)mbt-like 1 (Drosophila)
LLGL1 lethal giant larvae homolog 1 (Drosophila)
LTBP2 latent transforming growth factor beta binding protein 2
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPK7 mitogen-activated protein kinase 7
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MARK4 MAP/microtubule affinity-regulating kinase 4
MED25 mediator complex subunit 25
MID1 midline 1
MINK1 misshapen-like kinase 1
MKL1 megakaryoblastic leukemia (translocation) 1
MST1 macrophage stimulating 1
MYO9B myosin IXB
NAA11 N(alpha)-acetyltransferase 11, NatA catalytic subunit
NEUROD4 neuronal differentiation 4
NOL12 nucleolar protein 12
NRL neural retina leucine zipper
OBSL1 obscurin-like 1
OGG1 8-oxoguanine DNA glycosylase
PCDHGA8 protocadherin gamma subfamily A, 8
PRDM12 PR domain containing 12
PSG6 pregnancy specific beta-1-glycoprotein 6
PXDC1 PX domain containing 1
RAB3B RAB3B, member RAS oncogene family
RAD52 RAD52 homolog (S. cerevisiae)
RHAG Rh-associated glycoprotein
RIMS3 regulating synaptic membrane exocytosis 3
RPL35A ribosomal protein L35a
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SECTM1 secreted and transmembrane 1
SLC30A10 solute carrier family 30, member 10
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SMYD2 SET and MYND domain containing 2
SPPL2B signal peptide peptidase like 2B
STS steroid sulfatase (microsomal), isozyme S
TAGLN3 transgelin 3
TMPRSS6 transmembrane protease, serine 6
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TSNAXIP1 translin-associated factor X interacting protein 1
TTC39A tetratricopeptide repeat domain 39A
UPF3A UPF3 regulator of nonsense transcripts homolog A (yeast)
WDR62 WD repeat domain 62
ZFAND5 zinc finger, AN1-type domain 5
ZNF862 zinc finger protein 862

decreased expression

Symbol Name
ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12
AIRE autoimmune regulator
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ARMC4 armadillo repeat containing 4
ARR3 arrestin 3, retinal (X-arrestin)
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
BAGE B melanoma antigen
C11ORF30 chromosome 11 open reading frame 30
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CD53 CD53 molecule
CD82 CD82 molecule
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CENPO centromere protein O
CFAP70 cilia and flagella associated protein 70
CGA glycoprotein hormones, alpha polypeptide
CHM choroideremia (Rab escort protein 1)
CNPY4 canopy FGF signaling regulator 4
CPPED1 calcineurin-like phosphoesterase domain containing 1
CRIP1 cysteine-rich protein 1 (intestinal)
CUZD1 CUB and zona pellucida-like domains 1
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DYSF dysferlin
ERN1 endoplasmic reticulum to nucleus signaling 1
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM110B family with sequence similarity 110, member B
FAM46C family with sequence similarity 46, member C
FBXO2 F-box protein 2
FBXO4 F-box protein 4
FGF23 fibroblast growth factor 23
FRMD1 FERM domain containing 1
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GFI1 growth factor independent 1 transcription repressor
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GSTTP1 glutathione S-transferase theta pseudogene 1
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HIRA histone cell cycle regulator
HIST1H2AK histone cluster 1, H2ak
HIST1H4E histone cluster 1, H4e
HMOX1 heme oxygenase 1
HOXB2 homeobox B2
HOXC5 homeobox C5
HOXC8 homeobox C8
IBSP integrin-binding sialoprotein
IL12RB1 interleukin 12 receptor, beta 1
IL18 interleukin 18
INPP5J inositol polyphosphate-5-phosphatase J
ITM2C integral membrane protein 2C
KCNIP1 Kv channel interacting protein 1
KCNK15 potassium channel, two pore domain subfamily K, member 15
KCTD17 potassium channel tetramerization domain containing 17
KLRG1 killer cell lectin-like receptor subfamily G, member 1
KPNA5 karyopherin alpha 5 (importin alpha 6)
LRP3 low density lipoprotein receptor-related protein 3
MAGEA5 melanoma antigen family A5
MBNL3 muscleblind-like splicing regulator 3
MRPL41 mitochondrial ribosomal protein L41
MYO1E myosin IE
NEURL1 neuralized E3 ubiquitin protein ligase 1
NPIPB3 nuclear pore complex interacting protein family, member B3
NPY4R neuropeptide Y receptor Y4
NRSN2 neurensin 2
ONECUT2 one cut homeobox 2
OSGIN1 oxidative stress induced growth inhibitor 1
OSMR oncostatin M receptor
PADI1 peptidyl arginine deiminase, type I
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PRF1 perforin 1 (pore forming protein)
RELN reelin
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RPS14P3 ribosomal protein S14 pseudogene 3
S100A2 S100 calcium binding protein A2
SCUBE2 signal peptide, CUB domain, EGF-like 2
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
SLMO1 slowmo homolog 1 (Drosophila)
STEAP4 STEAP family member 4
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
TBKBP1 TBK1 binding protein 1
TM6SF1 transmembrane 6 superfamily member 1
TMC7 transmembrane channel-like 7
TMEM165 transmembrane protein 165
TMEM209 transmembrane protein 209
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TRPC5 transient receptor potential cation channel, subfamily C, member 5
TRPV1 transient receptor potential cation channel, subfamily V, member 1
URM1 ubiquitin related modifier 1
VPS9D1 VPS9 domain containing 1
VSIG10 V-set and immunoglobulin domain containing 10
XDH xanthine dehydrogenase
ZBTB48 zinc finger and BTB domain containing 48
ZFP37 ZFP37 zinc finger protein
ZNF606 zinc finger protein 606