sulfasalazine-204 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the sulfasalazine-204 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ABCF2 ATP-binding cassette, sub-family F (GCN20), member 2
ACTL8 actin-like 8
ADM2 adrenomedullin 2
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
API5 apoptosis inhibitor 5
ARHGAP33 Rho GTPase activating protein 33
ARNT aryl hydrocarbon receptor nuclear translocator
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ASCL1 achaete-scute family bHLH transcription factor 1
BAZ2A bromodomain adjacent to zinc finger domain, 2A
BCL2L14 BCL2-like 14 (apoptosis facilitator)
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
C17ORF59 chromosome 17 open reading frame 59
CARD9 caspase recruitment domain family, member 9
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEND1 cell cycle exit and neuronal differentiation 1
CFAP70 cilia and flagella associated protein 70
CLIP4 CAP-GLY domain containing linker protein family, member 4
CORO1B coronin, actin binding protein, 1B
CPT1A carnitine palmitoyltransferase 1A (liver)
CRABP1 cellular retinoic acid binding protein 1
CSE1L CSE1 chromosome segregation 1-like (yeast)
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
CYP2A7 cytochrome P450, family 2, subfamily A, polypeptide 7
DCN decorin
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DHODH dihydroorotate dehydrogenase (quinone)
DLK2 delta-like 2 homolog (Drosophila)
EFCAB14 EF-hand calcium binding domain 14
EFNB3 ephrin-B3
EMP3 epithelial membrane protein 3
EXTL3 exostosin-like glycosyltransferase 3
F5 coagulation factor V (proaccelerin, labile factor)
FAM76A family with sequence similarity 76, member A
FBLN1 fibulin 1
FBXO31 F-box protein 31
FSCN3 fascin actin-bundling protein 3, testicular
FXR2 fragile X mental retardation, autosomal homolog 2
GHRHR growth hormone releasing hormone receptor
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
GYPB glycophorin B (MNS blood group)
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IL15RA interleukin 15 receptor, alpha
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
LBP lipopolysaccharide binding protein
LMTK1 lemur tail kinase 1
MAP2K5 mitogen-activated protein kinase kinase 5
MARC1 mitochondrial amidoxime reducing component 1
MPZL2 myelin protein zero-like 2
MR1 major histocompatibility complex, class I-related
MT1G metallothionein 1G
MUC2 mucin 2, oligomeric mucus/gel-forming
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NCKIPSD NCK interacting protein with SH3 domain
NDRG2 NDRG family member 2
NR6A1 nuclear receptor subfamily 6, group A, member 1
NUDCD3 NudC domain containing 3
OGFOD3 2-oxoglutarate and iron-dependent oxygenase domain containing 3
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
OVOL1 ovo-like zinc finger 1
PADI2 peptidyl arginine deiminase, type II
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3
PAOX polyamine oxidase (exo-N4-amino)
PBX1 pre-B-cell leukemia homeobox 1
PCTP phosphatidylcholine transfer protein
PLA2G12A phospholipase A2, group XIIA
PPP1R7 protein phosphatase 1, regulatory subunit 7
PQLC3 PQ loop repeat containing 3
PRDM11 PR domain containing 11
PRDX2 peroxiredoxin 2
PTPN7 protein tyrosine phosphatase, non-receptor type 7
PVR poliovirus receptor
RAB4B RAB4B, member RAS oncogene family
RAD51D RAD51 paralog D
RPL10 ribosomal protein L10
S100A9 S100 calcium binding protein A9
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
SETD2 SET domain containing 2
SFSWAP splicing factor, suppressor of white-apricot family
SIGMAR1 sigma non-opioid intracellular receptor 1
SLC15A1 solute carrier family 15 (oligopeptide transporter), member 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC43A3 solute carrier family 43, member 3
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
SYT5 synaptotagmin V
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box)
TIAM2 T-cell lymphoma invasion and metastasis 2
TMEM127 transmembrane protein 127
TYR tyrosinase
UBOX5 U-box domain containing 5
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae)
WNT16 wingless-type MMTV integration site family, member 16
ZNF75D zinc finger protein 75D
ZNHIT2 zinc finger, HIT-type containing 2

decreased expression

Symbol Name
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ACVR2B activin A receptor, type IIB
ADGRL2 adhesion G protein-coupled receptor L2
ARR3 arrestin 3, retinal (X-arrestin)
ARSA arylsulfatase A
ASPA aspartoacylase
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
AXIN1 axin 1
CCDC176 coiled-coil domain containing 176
CCP110 centriolar coiled coil protein 110kDa
CD8A CD8a molecule
CIC capicua transcriptional repressor
CLDN11 claudin 11
CLSTN3 calsyntenin 3
CNTFR ciliary neurotrophic factor receptor
COG7 component of oligomeric golgi complex 7
COL4A3BP collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
COLEC11 collectin sub-family member 11
COLEC12 collectin sub-family member 12
DVL1 dishevelled segment polarity protein 1
ELMO3 engulfment and cell motility 3
FCHSD2 FCH and double SH3 domains 2
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GPA33 glycoprotein A33 (transmembrane)
GPRASP1 G protein-coupled receptor associated sorting protein 1
HEATR3 HEAT repeat containing 3
HIST1H4G histone cluster 1, H4g
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IL7R interleukin 7 receptor
ISYNA1 inositol-3-phosphate synthase 1
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KCTD3 potassium channel tetramerization domain containing 3
KLK8 kallikrein-related peptidase 8
KRT85 keratin 85, type II
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MATK megakaryocyte-associated tyrosine kinase
MEIS3P1 Meis homeobox 3 pseudogene 1
MPPED1 metallophosphoesterase domain containing 1
MT3 metallothionein 3
MYH7 myosin, heavy chain 7, cardiac muscle, beta
NEMF nuclear export mediator factor
NUBPL nucleotide binding protein-like
OCEL1 occludin/ELL domain containing 1
OSBPL11 oxysterol binding protein-like 11
OTUD3 OTU deubiquitinase 3
PABPC3 poly(A) binding protein, cytoplasmic 3
PAN2 PAN2 poly(A) specific ribonuclease subunit
PCDHA9 protocadherin alpha 9
PHC1 polyhomeotic homolog 1 (Drosophila)
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PKD2L1 polycystic kidney disease 2-like 1
POMT2 protein-O-mannosyltransferase 2
PRDM14 PR domain containing 14
PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
PWP2 PWP2 periodic tryptophan protein homolog (yeast)
QTRT1 queuine tRNA-ribosyltransferase 1
RANBP17 RAN binding protein 17
REC8 REC8 meiotic recombination protein
REST RE1-silencing transcription factor
RNF141 ring finger protein 141
S1PR4 sphingosine-1-phosphate receptor 4
SCARA3 scavenger receptor class A, member 3
SCML1 sex comb on midleg-like 1 (Drosophila)
SCUBE2 signal peptide, CUB domain, EGF-like 2
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SFMBT1 Scm-like with four mbt domains 1
SIL1 SIL1 nucleotide exchange factor
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
SMS spermine synthase
SMU1 smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans)
SNORA21 small nucleolar RNA, H/ACA box 21
SPON2 spondin 2, extracellular matrix protein
SPTBN5 spectrin, beta, non-erythrocytic 5
SSTR4 somatostatin receptor 4
SYF2 SYF2 pre-mRNA-splicing factor
SYNPO synaptopodin
TGM5 transglutaminase 5
THOC1 THO complex 1
TLR2 toll-like receptor 2
TMEM176A transmembrane protein 176A
TMEM184B transmembrane protein 184B
TMEM242 transmembrane protein 242
TMEM39B transmembrane protein 39B
TMUB2 transmembrane and ubiquitin-like domain containing 2
TRAC T cell receptor alpha constant
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TTI1 TELO2 interacting protein 1
VIM vimentin
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae)
VRK2 vaccinia related kinase 2
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
ZBED8 zinc finger, BED-type containing 8
ZFHX2 zinc finger homeobox 2
ZFHX4 zinc finger homeobox 4
ZFP36 ZFP36 ring finger protein
ZNF217 zinc finger protein 217