sulfinpyrazone-5753 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the sulfinpyrazone-5753 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACTN2 actinin, alpha 2
ADGRB2 adhesion G protein-coupled receptor B2
AHSP alpha hemoglobin stabilizing protein
AIF1 allograft inflammatory factor 1
AKR1C2 aldo-keto reductase family 1, member C2
AKT3 v-akt murine thymoma viral oncogene homolog 3
AMACR alpha-methylacyl-CoA racemase
ARID5A AT rich interactive domain 5A (MRF1-like)
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ATF7 activating transcription factor 7
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
BTNL3 butyrophilin-like 3
C10ORF10 chromosome 10 open reading frame 10
C1ORF95 chromosome 1 open reading frame 95
C9ORF156 chromosome 9 open reading frame 156
CA5B carbonic anhydrase VB, mitochondrial
CD53 CD53 molecule
CD6 CD6 molecule
CDH8 cadherin 8, type 2
COMT catechol-O-methyltransferase
CPB2 carboxypeptidase B2 (plasma)
CTIF CBP80/20-dependent translation initiation factor
DNAI2 dynein, axonemal, intermediate chain 2
DSCAM Down syndrome cell adhesion molecule
DYRK1B dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
DZIP1 DAZ interacting zinc finger protein 1
EDA ectodysplasin A
EDN1 endothelin 1
EGR4 early growth response 4
EMX1 empty spiracles homeobox 1
ENOX1 ecto-NOX disulfide-thiol exchanger 1
EPHA1 EPH receptor A1
FABP3 fatty acid binding protein 3, muscle and heart
FCMR Fc fragment of IgM receptor
FLJ11292
FOXG1 forkhead box G1
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2
GLE1 GLE1 RNA export mediator
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GPR21 G protein-coupled receptor 21
GYPC glycophorin C (Gerbich blood group)
HAP1 huntingtin-associated protein 1
HIST1H3E histone cluster 1, H3e
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HRH3 histamine receptor H3
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
IBSP integrin-binding sialoprotein
INE1 inactivation escape 1 (non-protein coding)
IQSEC2 IQ motif and Sec7 domain 2
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITPKA inositol-trisphosphate 3-kinase A
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KLHL25 kelch-like family member 25
KYNU kynureninase
LBP lipopolysaccharide binding protein
LINC00115 long intergenic non-protein coding RNA 115
LRRC15 leucine rich repeat containing 15
MEGF8 multiple EGF-like-domains 8
MFAP2 microfibrillar-associated protein 2
MYLPF myosin light chain, phosphorylatable, fast skeletal muscle
MYRIP myosin VIIA and Rab interacting protein
NCR2 natural cytotoxicity triggering receptor 2
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
NRXN3 neurexin 3
PCDHGC3 protocadherin gamma subfamily C, 3
PGP phosphoglycolate phosphatase
PHF2 PHD finger protein 2
PLCH2 phospholipase C, eta 2
PLEKHG3 pleckstrin homology domain containing, family G (with RhoGef domain) member 3
PLXNC1 plexin C1
POLL polymerase (DNA directed), lambda
PTGDS prostaglandin D2 synthase 21kDa (brain)
RASAL2 RAS protein activator like 2
RBM48 RNA binding motif protein 48
RBMS2 RNA binding motif, single stranded interacting protein 2
RETN resistin
RPL10 ribosomal protein L10
RPL10L ribosomal protein L10-like
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
SENP7 SUMO1/sentrin specific peptidase 7
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SYK spleen tyrosine kinase
TFEB transcription factor EB
TJP3 tight junction protein 3
TMEM74B transmembrane protein 74B
TRANK1 tetratricopeptide repeat and ankyrin repeat containing 1
TSHR thyroid stimulating hormone receptor
TSKS testis-specific serine kinase substrate
TTN titin
USP29 ubiquitin specific peptidase 29
WDR55 WD repeat domain 55
WRNIP1 Werner helicase interacting protein 1
ZNF507 zinc finger protein 507
ZNF639 zinc finger protein 639
ZNF76 zinc finger protein 76

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ADAP2 ArfGAP with dual PH domains 2
ADTRP androgen-dependent TFPI-regulating protein
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ANKFY1 ankyrin repeat and FYVE domain containing 1
ANXA10 annexin A10
APOL6 apolipoprotein L, 6
ARL15 ADP-ribosylation factor-like 15
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
BTC betacellulin
C1ORF56 chromosome 1 open reading frame 56
CA5BP1 carbonic anhydrase VB pseudogene 1
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCDC25 coiled-coil domain containing 25
CCNJ cyclin J
CDADC1 cytidine and dCMP deaminase domain containing 1
CDON cell adhesion associated, oncogene regulated
CHM choroideremia (Rab escort protein 1)
CLDN14 claudin 14
CLEC16A C-type lectin domain family 16, member A
CLSPN claspin
CXCL3 chemokine (C-X-C motif) ligand 3
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DCAF17 DDB1 and CUL4 associated factor 17
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila)
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
EHD3 EH-domain containing 3
EPHX2 epoxide hydrolase 2, cytoplasmic
ESM1 endothelial cell-specific molecule 1
ETNK2 ethanolamine kinase 2
FAM179B family with sequence similarity 179, member B
FAM184A family with sequence similarity 184, member A
FAM50B family with sequence similarity 50, member B
FBXL15 F-box and leucine-rich repeat protein 15
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GALK1 galactokinase 1
GAREM GRB2 associated, regulator of MAPK1
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GLCE glucuronic acid epimerase
GMEB1 glucocorticoid modulatory element binding protein 1
GRAMD1C GRAM domain containing 1C
GUSBP3 glucuronidase, beta pseudogene 3
HDAC7 histone deacetylase 7
HIST1H2AI histone cluster 1, H2ai
HOXC4 homeobox C4
IFI6 interferon, alpha-inducible protein 6
IL11RA interleukin 11 receptor, alpha
KDM7A lysine (K)-specific demethylase 7A
KIF3A kinesin family member 3A
KLF3 Kruppel-like factor 3 (basic)
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MVD mevalonate (diphospho) decarboxylase
NINJ1 ninjurin 1
NTSR1 neurotensin receptor 1 (high affinity)
OLFML2A olfactomedin-like 2A
P3H2 prolyl 3-hydroxylase 2
PHACTR4 phosphatase and actin regulator 4
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
POLH polymerase (DNA directed), eta
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
RAI2 retinoic acid induced 2
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
RFX7 regulatory factor X, 7
RPP25 ribonuclease P/MRP 25kDa subunit
RUSC2 RUN and SH3 domain containing 2
SCAI suppressor of cancer cell invasion
SCML2 sex comb on midleg-like 2 (Drosophila)
SCN9A sodium channel, voltage gated, type IX alpha subunit
SDC3 syndecan 3
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SETBP1 SET binding protein 1
SHPK sedoheptulokinase
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC46A3 solute carrier family 46, member 3
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SLITRK5 SLIT and NTRK-like family, member 5
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TM7SF3 transmembrane 7 superfamily member 3
TMC7 transmembrane channel-like 7
TMEM8B transmembrane protein 8B
TRAPPC13 trafficking protein particle complex 13
TRIM25 tripartite motif containing 25
VGF VGF nerve growth factor inducible
VWA1 von Willebrand factor A domain containing 1
YPEL1 yippee-like 1 (Drosophila)
ZFHX2 zinc finger homeobox 2
ZNF280D zinc finger protein 280D
ZNF354A zinc finger protein 354A
ZNF426 zinc finger protein 426
ZNF43 zinc finger protein 43
ZNF571 zinc finger protein 571
ZNF668 zinc finger protein 668
ZNF862 zinc finger protein 862