sulindac sulfone Gene Set

Dataset CTD Gene-Chemical Interactions
Category physical interactions
Type chemical
Description A sulfone metabolite of sulindac that inhibits cell growth by inducing apoptosis independently of cyclooxygenase inhibition. It inhibits the development and induces regression of premalignant adenomatous polyps. Lipoxygenase and Cox-2 inhibitor. (Chemical Entities of Biological Interest Ontology, CHEBI_64212)
External Link http://ctdbase.org/detail.go?type=chem&acc=C025463
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Genes

47 genes/proteins interacting with the chemical sulindac sulfone from the curated CTD Gene-Chemical Interactions dataset.

Symbol Name
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALOX15 arachidonate 15-lipoxygenase
AR androgen receptor
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CCND1 cyclin D1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
EGFR epidermal growth factor receptor
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ESR1 estrogen receptor 1
GATA6 GATA binding protein 6
GSTP1 glutathione S-transferase pi 1
HINT1 histidine triad nucleotide binding protein 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IL24 interleukin 24
KLK3 kallikrein-related peptidase 3
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K4 mitogen-activated protein kinase kinase 4
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MMP7 matrix metallopeptidase 7
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGFR nerve growth factor receptor
NQO1 NAD(P)H dehydrogenase, quinone 1
PCNA proliferating cell nuclear antigen
PDE2A phosphodiesterase 2A, cGMP-stimulated
PDE5A phosphodiesterase 5A, cGMP-specific
PGR progesterone receptor
PPARG peroxisome proliferator-activated receptor gamma
PRKG1 protein kinase, cGMP-dependent, type I
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
TNF tumor necrosis factor
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1
UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10
UGT1A3 UDP glucuronosyltransferase 1 family, polypeptide A3
UGT1A4 UDP glucuronosyltransferase 1 family, polypeptide A4
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7
VASP vasodilator-stimulated phosphoprotein
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon