sulindac-1857 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the sulindac-1857 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ABCD4 ATP-binding cassette, sub-family D (ALD), member 4
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
AMT aminomethyltransferase
APC adenomatous polyposis coli
ARG1 arginase 1
ASGR2 asialoglycoprotein receptor 2
B4GALT4 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4
BAZ1B bromodomain adjacent to zinc finger domain, 1B
CA12 carbonic anhydrase XII
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CDK20 cyclin-dependent kinase 20
CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3
CENPO centromere protein O
CHAT choline O-acetyltransferase
CREBZF CREB/ATF bZIP transcription factor
CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
CTSO cathepsin O
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DAPK1 death-associated protein kinase 1
DGAT1 diacylglycerol O-acyltransferase 1
DSPP dentin sialophosphoprotein
DUS4L dihydrouridine synthase 4-like (S. cerevisiae)
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2
FASLG Fas ligand (TNF superfamily, member 6)
FBXO41 F-box protein 41
FNTB farnesyltransferase, CAAX box, beta
FUZ fuzzy planar cell polarity protein
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like
GRIK5 glutamate receptor, ionotropic, kainate 5
HCFC1R1 host cell factor C1 regulator 1 (XPO1 dependent)
HIGD2A HIG1 hypoxia inducible domain family, member 2A
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
HOXA1 homeobox A1
HOXC8 homeobox C8
HYI hydroxypyruvate isomerase (putative)
IFT54 intraflagellar transport 54
IL27RA interleukin 27 receptor, alpha
ITGB1BP1 integrin beta 1 binding protein 1
ITGB4 integrin, beta 4
KIAA0513 KIAA0513
KRIT1 KRIT1, ankyrin repeat containing
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
LIME1 Lck interacting transmembrane adaptor 1
LINC00115 long intergenic non-protein coding RNA 115
LOC729164 hCG1732469
MAGED2 melanoma antigen family D2
MAZ MYC-associated zinc finger protein (purine-binding transcription factor)
MID2 midline 2
MIIP migration and invasion inhibitory protein
MIR22HG MIR22 host gene
MMP3 matrix metallopeptidase 3
MRPS12 mitochondrial ribosomal protein S12
MYO1C myosin IC
NCR2 natural cytotoxicity triggering receptor 2
NEB nebulin
OVGP1 oviductal glycoprotein 1, 120kDa
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLK4 polo-like kinase 4
POLL polymerase (DNA directed), lambda
PRKCI protein kinase C, iota
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
PVR poliovirus receptor
REC8 REC8 meiotic recombination protein
RPL35A ribosomal protein L35a
RPL7 ribosomal protein L7
RPS14 ribosomal protein S14
RPS2 ribosomal protein S2
RUNX1 runt-related transcription factor 1
SGSM3 small G protein signaling modulator 3
SIGLEC7 sialic acid binding Ig-like lectin 7
SLC39A9 solute carrier family 39, member 9
SLC48A1 solute carrier family 48 (heme transporter), member 1
SMAD6 SMAD family member 6
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SPG21 spastic paraplegia 21 (autosomal recessive, Mast syndrome)
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STK4 serine/threonine kinase 4
SYT2 synaptotagmin II
TAF1B TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa
TAPBP TAP binding protein (tapasin)
TCP11L1 t-complex 11, testis-specific-like 1
TCTN2 tectonic family member 2
THAP3 THAP domain containing, apoptosis associated protein 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM2D1 TM2 domain containing 1
TRIM58 tripartite motif containing 58
TSC22D4 TSC22 domain family, member 4
VN1R1 vomeronasal 1 receptor 1
ZBTB17 zinc finger and BTB domain containing 17
ZBTB40 zinc finger and BTB domain containing 40
ZNF155 zinc finger protein 155
ZNF324 zinc finger protein 324
ZNF500 zinc finger protein 500

decreased expression

Symbol Name
ACPP acid phosphatase, prostate
AMIGO2 adhesion molecule with Ig-like domain 2
ANKRD36 ankyrin repeat domain 36
BBC3 BCL2 binding component 3
BCL2L2 BCL2-like 2
C14ORF159 chromosome 14 open reading frame 159
C16ORF59 chromosome 16 open reading frame 59
C3 complement component 3
CCNJ cyclin J
CECR1 cat eye syndrome chromosome region, candidate 1
CEL carboxyl ester lipase
CENPT centromere protein T
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CIC capicua transcriptional repressor
CLUH clustered mitochondria (cluA/CLU1) homolog
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous)
CRADD CASP2 and RIPK1 domain containing adaptor with death domain
CRBN cereblon
CRIP1 cysteine-rich protein 1 (intestinal)
CRY2 cryptochrome circadian clock 2
DDT D-dopachrome tautomerase
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DOCK4 dedicator of cytokinesis 4
DSE dermatan sulfate epimerase
DTX4 deltex 4, E3 ubiquitin ligase
DYNLT1 dynein, light chain, Tctex-type 1
ECI2 enoyl-CoA delta isomerase 2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERMAP erythroblast membrane-associated protein (Scianna blood group)
FAM160B2 family with sequence similarity 160, member B2
GDI1 GDP dissociation inhibitor 1
GPR63 G protein-coupled receptor 63
GPRC5C G protein-coupled receptor, class C, group 5, member C
GPX4 glutathione peroxidase 4
IFNAR1 interferon (alpha, beta and omega) receptor 1
IPO8 importin 8
IRF8 interferon regulatory factor 8
KIAA0754 KIAA0754
LPPR2 lipid phosphate phosphatase-related protein type 2
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
LY6E lymphocyte antigen 6 complex, locus E
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MBOAT2 membrane bound O-acyltransferase domain containing 2
MMP2 matrix metallopeptidase 2
MON1B MON1 secretory trafficking family member B
MUM1 melanoma associated antigen (mutated) 1
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit
NECAP1 NECAP endocytosis associated 1
NOD1 nucleotide-binding oligomerization domain containing 1
NPM3 nucleophosmin/nucleoplasmin 3
NUS1P3 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) pseudogene 3
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
PDGFD platelet derived growth factor D
PFAS phosphoribosylformylglycinamidine synthase
PIAS3 protein inhibitor of activated STAT, 3
PPCS phosphopantothenoylcysteine synthetase
PRR7 proline rich 7 (synaptic)
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1
PYGB phosphorylase, glycogen; brain
RAB5C RAB5C, member RAS oncogene family
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RHOH ras homolog family member H
RWDD3 RWD domain containing 3
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SIRT6 sirtuin 6
SKA1 spindle and kinetochore associated complex subunit 1
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC35E3 solute carrier family 35, member E3
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SNHG20 small nucleolar RNA host gene 20
SPAG4 sperm associated antigen 4
TAF11 TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa
TBX19 T-box 19
TESC tescalcin
TFEB transcription factor EB
TGS1 trimethylguanosine synthase 1
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TMEM127 transmembrane protein 127
TRIP10 thyroid hormone receptor interactor 10
TSR2 TSR2, 20S rRNA accumulation, homolog (S. cerevisiae)
TTBK2 tau tubulin kinase 2
UBXN6 UBX domain protein 6
ULK1 unc-51 like autophagy activating kinase 1
UPB1 ureidopropionase, beta
VCPKMT valosin containing protein lysine (K) methyltransferase
WDR91 WD repeat domain 91
WT1-AS WT1 antisense RNA
ZCCHC8 zinc finger, CCHC domain containing 8
ZDHHC11 zinc finger, DHHC-type containing 11
ZDHHC18 zinc finger, DHHC-type containing 18
ZDHHC24 zinc finger, DHHC-type containing 24
ZKSCAN3 zinc finger with KRAB and SCAN domains 3
ZNF10 zinc finger protein 10
ZNF574 zinc finger protein 574
ZNF862 zinc finger protein 862