sulindac-5528 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the sulindac-5528 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACPP acid phosphatase, prostate
AMN amnion associated transmembrane protein
AMT aminomethyltransferase
APC adenomatous polyposis coli
ARID4B AT rich interactive domain 4B (RBP1-like)
ATAD5 ATPase family, AAA domain containing 5
BAZ2A bromodomain adjacent to zinc finger domain, 2A
C11ORF63 chromosome 11 open reading frame 63
CA9 carbonic anhydrase IX
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CACNG4 calcium channel, voltage-dependent, gamma subunit 4
CCL4 chemokine (C-C motif) ligand 4
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDHR2 cadherin-related family member 2
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal)
COL1A1 collagen, type I, alpha 1
COL7A1 collagen, type VII, alpha 1
COL8A1 collagen, type VIII, alpha 1
CPED1 cadherin-like and PC-esterase domain containing 1
CRTC1 CREB regulated transcription coactivator 1
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCBLD2 discoidin, CUB and LCCL domain containing 2
DRD2 dopamine receptor D2
DST dystonin
ELOVL2 ELOVL fatty acid elongase 2
FLT4 fms-related tyrosine kinase 4
FN1 fibronectin 1
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GAS2 growth arrest-specific 2
GPR162 G protein-coupled receptor 162
GRIK5 glutamate receptor, ionotropic, kainate 5
GUCY1A2 guanylate cyclase 1, soluble, alpha 2
HAB1 B1 for mucin
HIST1H1E histone cluster 1, H1e
HIST1H4E histone cluster 1, H4e
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
HYAL3 hyaluronoglucosaminidase 3
IFNA10 interferon, alpha 10
IFT122 intraflagellar transport 122
IGLJ3 immunoglobulin lambda joining 3
ITIH5 inter-alpha-trypsin inhibitor heavy chain family, member 5
KANK1 KN motif and ankyrin repeat domains 1
KATNB1 katanin p80 (WD repeat containing) subunit B 1
KCNG1 potassium channel, voltage gated modifier subfamily G, member 1
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KIF13A kinesin family member 13A
KLRF1 killer cell lectin-like receptor subfamily F, member 1
LHB luteinizing hormone beta polypeptide
LOC51145 uncharacterized LOC51145
MAN2A2 mannosidase, alpha, class 2A, member 2
MAPK10 mitogen-activated protein kinase 10
MCTP1 multiple C2 domains, transmembrane 1
MOCS1 molybdenum cofactor synthesis 1
MXD3 MAX dimerization protein 3
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
PAIP2B poly(A) binding protein interacting protein 2B
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PAX7 paired box 7
PCDHB3 protocadherin beta 3
PFDN6 prefoldin subunit 6
PHF20 PHD finger protein 20
PITX1 paired-like homeodomain 1
PKNOX2 PBX/knotted 1 homeobox 2
PLEKHO2 pleckstrin homology domain containing, family O member 2
PLK3 polo-like kinase 3
POFUT1 protein O-fucosyltransferase 1
PRKCE protein kinase C, epsilon
RBM19 RNA binding motif protein 19
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila)
RPS14 ribosomal protein S14
RPS28 ribosomal protein S28
SEMA4G sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
SIGLEC7 sialic acid binding Ig-like lectin 7
SIX1 SIX homeobox 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC35G2 solute carrier family 35, member G2
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
SLN sarcolipin
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae)
SZT2 seizure threshold 2 homolog (mouse)
TCL6 T-cell leukemia/lymphoma 6 (non-protein coding)
TCP11L1 t-complex 11, testis-specific-like 1
TGM2 transglutaminase 2
TK2 thymidine kinase 2, mitochondrial
TM4SF20 transmembrane 4 L six family member 20
TPMT thiopurine S-methyltransferase
VEGFB vascular endothelial growth factor B
WDFY3 WD repeat and FYVE domain containing 3
WWOX WW domain containing oxidoreductase
ZBTB22 zinc finger and BTB domain containing 22
ZNF419 zinc finger protein 419
ZNF747 zinc finger protein 747

decreased expression

Symbol Name
AARSD1 alanyl-tRNA synthetase domain containing 1
ADGRG2 adhesion G protein-coupled receptor G2
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
BBS7 Bardet-Biedl syndrome 7
C1QTNF3 C1q and tumor necrosis factor related protein 3
C21ORF91 chromosome 21 open reading frame 91
C9ORF9 chromosome 9 open reading frame 9
CASD1 CAS1 domain containing 1
CBX4 chromobox homolog 4
CCNL2 cyclin L2
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CD83 CD83 molecule
CDR2L cerebellar degeneration-related protein 2-like
CEP97 centrosomal protein 97kDa
CHKB choline kinase beta
CLSPN claspin
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
COBL cordon-bleu WH2 repeat protein
COCH cochlin
CPSF7 cleavage and polyadenylation specific factor 7, 59kDa
CRADD CASP2 and RIPK1 domain containing adaptor with death domain
CTNND2 catenin (cadherin-associated protein), delta 2
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila)
DUSP5 dual specificity phosphatase 5
EAF2 ELL associated factor 2
ELOVL4 ELOVL fatty acid elongase 4
ELSPBP1 epididymal sperm binding protein 1
F3 coagulation factor III (thromboplastin, tissue factor)
FBXL15 F-box and leucine-rich repeat protein 15
FILIP1L filamin A interacting protein 1-like
FURIN furin (paired basic amino acid cleaving enzyme)
GATB glutamyl-tRNA(Gln) amidotransferase, subunit B
GPATCH2L G patch domain containing 2-like
GPX2 glutathione peroxidase 2
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
HECTD3 HECT domain containing E3 ubiquitin protein ligase 3
HIRA histone cell cycle regulator
HIST1H1D histone cluster 1, H1d
HIST1H4D histone cluster 1, H4d
HSPA2 heat shock 70kDa protein 2
IMPACT impact RWD domain protein
ITPKB inositol-trisphosphate 3-kinase B
ITPKC inositol-trisphosphate 3-kinase C
KAT2A K(lysine) acetyltransferase 2A
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3
KLF11 Kruppel-like factor 11
LAMA3 laminin, alpha 3
LMO2 LIM domain only 2 (rhombotin-like 1)
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LRP5L low density lipoprotein receptor-related protein 5-like
LRRC37A2 leucine rich repeat containing 37, member A2
LY6D lymphocyte antigen 6 complex, locus D
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MSL2 male-specific lethal 2 homolog (Drosophila)
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MYL5 myosin, light chain 5, regulatory
ORAI3 ORAI calcium release-activated calcium modulator 3
PCDHA9 protocadherin alpha 9
PKN1 protein kinase N1
POPDC3 popeye domain containing 3
PTCD2 pentatricopeptide repeat domain 2
RASA2 RAS p21 protein activator 2
REEP4 receptor accessory protein 4
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RFTN1 raftlin, lipid raft linker 1
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RIN2 Ras and Rab interactor 2
RIPK4 receptor-interacting serine-threonine kinase 4
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SCN1B sodium channel, voltage gated, type I beta subunit
SETD8 SET domain containing (lysine methyltransferase) 8
SIRT6 sirtuin 6
SKA1 spindle and kinetochore associated complex subunit 1
SLC12A9 solute carrier family 12, member 9
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SMIM14 small integral membrane protein 14
STXBP2 syntaxin binding protein 2
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TEAD3 TEA domain family member 3
TMEM180 transmembrane protein 180
TMEM242 transmembrane protein 242
TMPRSS3 transmembrane protease, serine 3
TMUB2 transmembrane and ubiquitin-like domain containing 2
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein
TSSC4 tumor suppressing subtransferable candidate 4
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
UBXN6 UBX domain protein 6
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2
VAX2 ventral anterior homeobox 2
WDR19 WD repeat domain 19
WDR62 WD repeat domain 62
ZNF350 zinc finger protein 350
ZNF365 zinc finger protein 365
ZNF768 zinc finger protein 768