sulindac Gene Set

Dataset	GeneRIF Biological Term Annotations
Category	structural or functional annotations
Type	biological term
Description	A monocarboxylic acid that is 1-benzylidene-1H-indene which is substituted at positions 2, 3, and 5 by methyl, carboxymethyl, and fluorine respectively, and in which the phenyl group of the benzylidene moiety is substituted at the para position by a methylsulfinyl group. It is a prodrug for the corresponding sulfide, a non-steroidal anti-inflammatory drug, used particularly in the treatment of acute and chronic inflammatory conditions. (Chemical Entities of Biological Interest Ontology, CHEBI_9352)
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Genes

14 genes co-occuring with the biological term sulindac in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol	Name
APC	adenomatous polyposis coli
BIRC5	baculoviral IAP repeat containing 5
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa
EGFR	epidermal growth factor receptor
HPGD	hydroxyprostaglandin dehydrogenase 15-(NAD)
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
MAP2K1	mitogen-activated protein kinase kinase 1
PDE5A	phosphodiesterase 5A, cGMP-specific
PPARD	peroxisome proliferator-activated receptor delta
RELA	v-rel avian reticuloendotheliosis viral oncogene homolog A
SAT1	spermidine/spermine N1-acetyltransferase 1
STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)
WNT1	wingless-type MMTV integration site family, member 1