suxibuzone-6065 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the suxibuzone-6065 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
AGO4 argonaute RISC catalytic component 4
APLP1 amyloid beta (A4) precursor-like protein 1
ARTN artemin
ATP8A2 ATPase, aminophospholipid transporter, class I, type 8A, member 2
BAIAP3 BAI1-associated protein 3
BMP1 bone morphogenetic protein 1
BTNL2 butyrophilin-like 2
C1QL1 complement component 1, q subcomponent-like 1
CA5B carbonic anhydrase VB, mitochondrial
CASP4 caspase 4, apoptosis-related cysteine peptidase
CCL27 chemokine (C-C motif) ligand 27
CD3D CD3d molecule, delta (CD3-TCR complex)
CDK18 cyclin-dependent kinase 18
CDO1 cysteine dioxygenase type 1
CERS4 ceramide synthase 4
CHRNG cholinergic receptor, nicotinic, gamma (muscle)
CLCN4 chloride channel, voltage-sensitive 4
CLCN6 chloride channel, voltage-sensitive 6
CLEC3B C-type lectin domain family 3, member B
CLPS colipase, pancreatic
COL5A2 collagen, type V, alpha 2
CTSZ cathepsin Z
CXCR2 chemokine (C-X-C motif) receptor 2
CXCR4 chemokine (C-X-C motif) receptor 4
DEFB126 defensin, beta 126
DGCR8 DGCR8 microprocessor complex subunit
EHD1 EH-domain containing 1
EML2 echinoderm microtubule associated protein like 2
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
FAM212B family with sequence similarity 212, member B
FAXDC2 fatty acid hydroxylase domain containing 2
FCAR Fc fragment of IgA receptor
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FKRP fukutin related protein
FOXI1 forkhead box I1
FRMD4B FERM domain containing 4B
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
GK3P glycerol kinase 3 pseudogene
GP5 glycoprotein V (platelet)
GPR153 G protein-coupled receptor 153
GPR176 G protein-coupled receptor 176
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B
GSK3A glycogen synthase kinase 3 alpha
HCG4 HLA complex group 4 (non-protein coding)
HEXA-AS1 HEXA antisense RNA 1
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
HIST1H4A histone cluster 1, H4a
HOXA1 homeobox A1
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled
IGFBP5 insulin-like growth factor binding protein 5
IGLV3-19 immunoglobulin lambda variable 3-19
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL23A interleukin 23, alpha subunit p19
INE1 inactivation escape 1 (non-protein coding)
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KIFC3 kinesin family member C3
KLF13 Kruppel-like factor 13
LECT2 leukocyte cell-derived chemotaxin 2
LIMCH1 LIM and calponin homology domains 1
LTBP4 latent transforming growth factor beta binding protein 4
MAGEA12 melanoma antigen family A12
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MEOX2 mesenchyme homeobox 2
MMP25 matrix metallopeptidase 25
MON2 MON2 homolog (S. cerevisiae)
MYL4 myosin, light chain 4, alkali; atrial, embryonic
OAZ3 ornithine decarboxylase antizyme 3
OR1G1 olfactory receptor, family 1, subfamily G, member 1
PHF7 PHD finger protein 7
PKNOX2 PBX/knotted 1 homeobox 2
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
PLXNB3 plexin B3
PML promyelocytic leukemia
PPP5C protein phosphatase 5, catalytic subunit
PRX periaxin
PTAFR platelet-activating factor receptor
R3HDM1 R3H domain containing 1
RAB14 RAB14, member RAS oncogene family
RAB30 RAB30, member RAS oncogene family
RGS12 regulator of G-protein signaling 12
RTN2 reticulon 2
SLC14A2 solute carrier family 14 (urea transporter), member 2
SLC26A1 solute carrier family 26 (anion exchanger), member 1
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SMIM14 small integral membrane protein 14
SNTA1 syntrophin, alpha 1
SOAT2 sterol O-acyltransferase 2
SPG20 spastic paraplegia 20 (Troyer syndrome)
SPTB spectrin, beta, erythrocytic
STATH statherin
TBKBP1 TBK1 binding protein 1
TGM1 transglutaminase 1
TMPRSS6 transmembrane protease, serine 6
TNIK TRAF2 and NCK interacting kinase
TNPO2 transportin 2
TTC38 tetratricopeptide repeat domain 38
TTC39A tetratricopeptide repeat domain 39A
ZFP64 ZFP64 zinc finger protein

decreased expression

Symbol Name
A1CF APOBEC1 complementation factor
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ADAM23 ADAM metallopeptidase domain 23
AGMAT agmatine ureohydrolase (agmatinase)
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
AUTS2 autism susceptibility candidate 2
BMP10 bone morphogenetic protein 10
C11ORF30 chromosome 11 open reading frame 30
C22ORF46 chromosome 22 open reading frame 46
C2ORF44 chromosome 2 open reading frame 44
C3ORF18 chromosome 3 open reading frame 18
CA5BP1 carbonic anhydrase VB pseudogene 1
CCDC132 coiled-coil domain containing 132
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CNTN1 contactin 1
COPZ2 coatomer protein complex, subunit zeta 2
CORO7 coronin 7
CPA4 carboxypeptidase A4
CRELD1 cysteine-rich with EGF-like domains 1
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
FGGY FGGY carbohydrate kinase domain containing
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
GMPR guanosine monophosphate reductase
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GRB7 growth factor receptor-bound protein 7
GUSBP3 glucuronidase, beta pseudogene 3
HAMP hepcidin antimicrobial peptide
HIST1H2AI histone cluster 1, H2ai
HIST1H2BC histone cluster 1, H2bc
HOXA4 homeobox A4
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
HSPB6 heat shock protein, alpha-crystallin-related, B6
IFNA14 interferon, alpha 14
IFT140 intraflagellar transport 140
IL22 interleukin 22
INPP5J inositol polyphosphate-5-phosphatase J
IRF2BP1 interferon regulatory factor 2 binding protein 1
ITGA10 integrin, alpha 10
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KIAA0125 KIAA0125
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
KLHL25 kelch-like family member 25
KRT24 keratin 24, type I
LARP6 La ribonucleoprotein domain family, member 6
LMO2 LIM domain only 2 (rhombotin-like 1)
LRRC20 leucine rich repeat containing 20
LTBP2 latent transforming growth factor beta binding protein 2
MYLK myosin light chain kinase
NKX3-2 NK3 homeobox 2
NME5 NME/NM23 family member 5
NPIPB3 nuclear pore complex interacting protein family, member B3
OR1D2 olfactory receptor, family 1, subfamily D, member 2
PAIP2B poly(A) binding protein interacting protein 2B
PCDHA9 protocadherin alpha 9
PCDHGB5 protocadherin gamma subfamily B, 5
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PMCHL1 pro-melanin-concentrating hormone-like 1, pseudogene
PPARG peroxisome proliferator-activated receptor gamma
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1
PSKH1 protein serine kinase H1
PTPN14 protein tyrosine phosphatase, non-receptor type 14
QPCTL glutaminyl-peptide cyclotransferase-like
RAD54L2 RAD54-like 2 (S. cerevisiae)
RANGRF RAN guanine nucleotide release factor
RNF126P1 ring finger protein 126 pseudogene 1
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SIX1 SIX homeobox 1
SLC17A2 solute carrier family 17, member 2
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLMO1 slowmo homolog 1 (Drosophila)
STARD3 StAR-related lipid transfer (START) domain containing 3
SYCP2 synaptonemal complex protein 2
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TGFBR1 transforming growth factor, beta receptor 1
THRAP3 thyroid hormone receptor associated protein 3
TM6SF1 transmembrane 6 superfamily member 1
TMEM121 transmembrane protein 121
TMEM242 transmembrane protein 242
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TRABD TraB domain containing
TRPV6 transient receptor potential cation channel, subfamily V, member 6
UBXN6 UBX domain protein 6
WDR25 WD repeat domain 25
WNT10B wingless-type MMTV integration site family, member 10B
XYLT1 xylosyltransferase I
ZNF136 zinc finger protein 136
ZNF329 zinc finger protein 329
ZNF711 zinc finger protein 711
ZNF767P zinc finger family member 767, pseudogene