suxibuzone Gene Set

Dataset	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures
Category	transcriptomics
Type	small molecule perturbation
Description	A member of the class of pyrazolidines that is phenylbutazone which is substituted by a 3-carboxypropanoylmethyl group at the 4-position. Suxibuzone is a prodrug for phenylbutazone and is commonly used as an anti-inflammatory drug in horses. (Chemical Entities of Biological Interest Ontology, CHEBI_32173)
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Genes

15 genes differentially expressed following the suxibuzone small molecule perturbation from the LINCS L1000 CMAP Chemical Perturbation Consensus Signatures dataset.

increased expression

Symbol	Name	Standardized Value
ICAM1	intercellular adhesion molecule 1	4.50998
CASP10	caspase 10, apoptosis-related cysteine peptidase	4.30497
C5	complement component 5	3.79319
KLHDC2	kelch domain containing 2	3.21949
RASA1	RAS p21 protein activator (GTPase activating protein) 1	3.0731
SLC15A2	solute carrier family 15 (oligopeptide transporter), member 2	3.06698
PLSCR1	phospholipid scramblase 1	3.06288

decreased expression

Symbol	Name	Standardized Value
CDC25B	cell division cycle 25B	-4.76582
IARS2	isoleucyl-tRNA synthetase 2, mitochondrial	-3.99529
TNFRSF21	tumor necrosis factor receptor superfamily, member 21	-3.99024
TRAPPC6A	trafficking protein particle complex 6A	-3.39768
PARP2	poly (ADP-ribose) polymerase 2	-3.32209
HS2ST1	heparan sulfate 2-O-sulfotransferase 1	-3.25615
GLI2	GLI family zinc finger 2	-3.24112
CA12	carbonic anhydrase XII	-3.04056