syk Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description spleen tyrosine kinase|This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010] (NCBI Entrez Gene Database, 6850)
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Genes

116 genes co-occuring with the biological term syk in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ACTA1 actin, alpha 1, skeletal muscle
ADRBK1 adrenergic, beta, receptor kinase 1
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKT1 v-akt murine thymoma viral oncogene homolog 1
ANGPTL2 angiopoietin-like 2
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
BCAR1 breast cancer anti-estrogen resistance 1
BCL2L1 BCL2-like 1
BLNK B-cell linker
BTK Bruton agammaglobulinemia tyrosine kinase
BTLA B and T lymphocyte associated
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCL20 chemokine (C-C motif) ligand 20
CD14 CD14 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD58 CD58 molecule
CD69 CD69 molecule
CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CLEC1B C-type lectin domain family 1, member B
CLEC4C C-type lectin domain family 4, member C
CLEC7A C-type lectin domain family 7, member A
CLTC clathrin, heavy chain (Hc)
CR2 complement component (3d/Epstein Barr virus) receptor 2
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CSF3R colony stimulating factor 3 receptor (granulocyte)
CTTN cortactin
CXCL12 chemokine (C-X-C motif) ligand 12
DOK3 docking protein 3
EDN1 endothelin 1
EGFR epidermal growth factor receptor
ELK1 ELK1, member of ETS oncogene family
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
EZR ezrin
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
FCRL4 Fc receptor-like 4
FLT1 fms-related tyrosine kinase 1
FYN FYN proto-oncogene, Src family tyrosine kinase
GP6 glycoprotein VI (platelet)
GRB2 growth factor receptor-bound protein 2
GSK3B glycogen synthase kinase 3 beta
HCLS1 hematopoietic cell-specific Lyn substrate 1
HTRA2 HtrA serine peptidase 2
ICAM1 intercellular adhesion molecule 1
IFNA1 interferon, alpha 1
IL2 interleukin 2
IL3 interleukin 3
IL4R interleukin 4 receptor
INPPL1 inositol polyphosphate phosphatase-like 1
IRF3 interferon regulatory factor 3
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
JAK3 Janus kinase 3
JUN jun proto-oncogene
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLRF1 killer cell lectin-like receptor subfamily F, member 1
LAT linker for activation of T cells
LCK LCK proto-oncogene, Src family tyrosine kinase
LYN LYN proto-oncogene, Src family tyrosine kinase
MAP2K4 mitogen-activated protein kinase kinase 4
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPT microtubule-associated protein tau
MCL1 myeloid cell leukemia 1
NLRP3 NLR family, pyrin domain containing 3
NOS2 nitric oxide synthase 2, inducible
NUCLEOLIN nucleolin multifunctional protein
P2RY12 purinergic receptor P2Y, G-protein coupled, 12
PECAM1 platelet/endothelial cell adhesion molecule 1
PF4 platelet factor 4
PHB prohibitin
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLAU plasminogen activator, urokinase
PLCG1 phospholipase C, gamma 1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PRKCD protein kinase C, delta
PTK2 protein tyrosine kinase 2
PTPRO protein tyrosine phosphatase, receptor type, O
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
ROR2 receptor tyrosine kinase-like orphan receptor 2
S100A2 S100 calcium binding protein A2
SELPLG selectin P ligand
SH3KBP1 SH3-domain kinase binding protein 1
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group)
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STMN1 stathmin 1
SYK spleen tyrosine kinase
TGFB1 transforming growth factor, beta 1
THBS1 thrombospondin 1
TLR1 toll-like receptor 1
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TRAF3IP2 TRAF3 interacting protein 2
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRAIP TRAF interacting protein
TYRO3 TYRO3 protein tyrosine kinase
UBASH3A ubiquitin associated and SH3 domain containing A
UBASH3B ubiquitin associated and SH3 domain containing B
USP25 ubiquitin specific peptidase 25
VAV1 vav 1 guanine nucleotide exchange factor
VEGFC vascular endothelial growth factor C
VWF von Willebrand factor
WNK4 WNK lysine deficient protein kinase 4
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa