syk Gene Set

Dataset Phosphosite Textmining Biological Term Annotations
Category structural or functional annotations
Type biological term
Description spleen tyrosine kinase|This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010] (NCBI Entrez Gene Database, 6850)
Similar Terms
Downloads & Tools

Genes

69 proteins co-occuring with the biological term syk in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

Symbol Name
ACVR1B activin A receptor, type IB
ADK adenosine kinase
AKT1 v-akt murine thymoma viral oncogene homolog 1
BLNK B-cell linker
BTK Bruton agammaglobulinemia tyrosine kinase
C6ORF25 chromosome 6 open reading frame 25
CARD9 caspase recruitment domain family, member 9
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CD19 CD19 molecule
CD22 CD22 molecule
CD79A CD79a molecule, immunoglobulin-associated alpha
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CLEC1B C-type lectin domain family 1, member B
CLTC clathrin, heavy chain (Hc)
CREB1 cAMP responsive element binding protein 1
DBNL drebrin-like
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
FCRL3 Fc receptor-like 3
FCRL4 Fc receptor-like 4
FGB fibrinogen beta chain
GCSAM germinal center-associated, signaling and motility
GSK3B glycogen synthase kinase 3 beta
HCLS1 hematopoietic cell-specific Lyn substrate 1
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IRS1 insulin receptor substrate 1
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
KLRF1 killer cell lectin-like receptor subfamily F, member 1
LAT linker for activation of T cells
LAT2 linker for activation of T cells family, member 2
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MAPT microtubule-associated protein tau
MS4A2 membrane-spanning 4-domains, subfamily A, member 2
NAGK N-acetylglucosamine kinase
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOS3 nitric oxide synthase 3 (endothelial cell)
P2RX6 purinergic receptor P2X, ligand gated ion channel, 6
PECAM1 platelet/endothelial cell adhesion molecule 1
PIK3AP1 phosphoinositide-3-kinase adaptor protein 1
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PLCG1 phospholipase C, gamma 1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PRKCQ protein kinase C, theta
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RHBG Rh family, B glycoprotein (gene/pseudogene)
SH3BP2 SH3-domain binding protein 2
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SIT1 signaling threshold regulating transmembrane adaptor 1
SLAMF1 signaling lymphocytic activation molecule family member 1
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group)
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAT5A signal transducer and activator of transcription 5A
SWAP70 SWAP switching B-cell complex 70kDa subunit
SYK spleen tyrosine kinase
WIPF1 WAS/WASL interacting protein family, member 1
WNK2 WNK lysine deficient protein kinase 2
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa