syndactyly Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description A synostosis that results_in the fusion of two or more digits. (Human Disease Ontology, DOID_11193)
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Genes

197 genes co-occuring with the disease syndactyly in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
FRAS1 Fraser extracellular matrix complex subunit 1 2.24736
NOG noggin 2.11388
HOXD13 homeobox D13 2.11242
FGFR2 fibroblast growth factor receptor 2 1.97036
FREM2 FRAS1 related extracellular matrix protein 2 1.96708
FREM1 FRAS1 related extracellular matrix 1 1.81284
GJA1 gap junction protein, alpha 1, 43kDa 1.76049
DHCR7 7-dehydrocholesterol reductase 1.72
GLI3 GLI family zinc finger 3 1.69542
GDF5 growth differentiation factor 5 1.59653
FBXW4 F-box and WD repeat domain containing 4 1.58849
PVRL4 poliovirus receptor-related 4 1.57467
LMBR1 limb development membrane protein 1 1.57111
FAM58A family with sequence similarity 58, member A 1.52336
EVX2 even-skipped homeobox 2 1.47945
MSX2 msh homeobox 2 1.46012
FGF8 fibroblast growth factor 8 (androgen-induced) 1.42235
ZP2 zona pellucida glycoprotein 2 (sperm receptor) 1.38734
SHH sonic hedgehog 1.38341
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 1.33196
DLX1 distal-less homeobox 1 1.33021
SMOC1 SPARC related modular calcium binding 1 1.29483
FREM3 FRAS1 related extracellular matrix 3 1.26081
BMP4 bone morphogenetic protein 4 1.25341
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 1.24385
ROR2 receptor tyrosine kinase-like orphan receptor 2 1.23603
SHFM1 split hand/foot malformation (ectrodactyly) type 1 1.22345
C17ORF67 chromosome 17 open reading frame 67 1.20439
LRP4 low density lipoprotein receptor-related protein 4 1.1635
MSX1 msh homeobox 1 1.1541
ADAMTS20 ADAM metallopeptidase with thrombospondin type 1 motif, 20 1.1367
HOXD12 homeobox D12 1.13036
NUBP2 nucleotide binding protein 2 1.11856
ATRNL1 attractin-like 1 1.11015
SOST sclerostin 1.09083
BMPR1B bone morphogenetic protein receptor, type IB 1.08412
HOXD1 homeobox D1 1.07152
TP63 tumor protein p63 1.07068
FBN2 fibrillin 2 1.06312
NUBP1 nucleotide binding protein 1 1.05429
VWA2 von Willebrand factor A domain containing 2 1.05303
WNT9A wingless-type MMTV integration site family, member 9A 1.0484
NEK1 NIMA-related kinase 1 1.03577
EN1 engrailed homeobox 1 1.03114
HOXD11 homeobox D11 1.02819
SOSTDC1 sclerostin domain containing 1 1.02102
ALX4 ALX homeobox 4 1.01891
COL26A1 collagen, type XXVI, alpha 1 1.00837
ISOC1 isochorismatase domain containing 1 1.00119
DLX6 distal-less homeobox 6 0.983479
PORCN porcupine homolog (Drosophila) 0.977165
PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C) 0.97128
FGFR1 fibroblast growth factor receptor 1 0.956196
IHH indian hedgehog 0.939119
DLX5 distal-less homeobox 5 0.934556
LAMA5 laminin, alpha 5 0.928346
FBLN1 fibulin 1 0.914727
FGF10 fibroblast growth factor 10 0.906498
EVC Ellis van Creveld protein 0.894589
CCNL2 cyclin L2 0.880243
CHD2 chromodomain helicase DNA binding protein 2 0.850764
HOXA13 homeobox A13 0.842573
ZFHX4 zinc finger homeobox 4 0.841344
KLF7 Kruppel-like factor 7 (ubiquitous) 0.836837
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 0.824538
BRD4 bromodomain containing 4 0.824128
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) 0.818385
YIPF4 Yip1 domain family, member 4 0.817565
FOXK2 forkhead box K2 0.806077
EFNB1 ephrin-B1 0.805667
CHRDL1 chordin-like 1 0.783936
FGFR3 fibroblast growth factor receptor 3 0.782298
BMP7 bone morphogenetic protein 7 0.776568
MYO9A myosin IXA 0.767167
EIF6 eukaryotic translation initiation factor 6 0.766759
NPNT nephronectin 0.756971
OFD1 oral-facial-digital syndrome 1 0.75412
HOXD8 homeobox D8 0.739082
GDF11 growth differentiation factor 11 0.733001
DOK7 docking protein 7 0.730976
CKAP5 cytoskeleton associated protein 5 0.730166
PTER phosphotriesterase related 0.72612
WNT7A wingless-type MMTV integration site family, member 7A 0.693499
GREM1 gremlin 1, DAN family BMP antagonist 0.685891
RAPSN receptor-associated protein of the synapse 0.670333
CIDEB cell death-inducing DFFA-like effector b 0.665563
WDR35 WD repeat domain 35 0.650113
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 0.647743
CDK10 cyclin-dependent kinase 10 0.646559
IFT80 intraflagellar transport 80 0.646559
BMP2 bone morphogenetic protein 2 0.629635
FGF4 fibroblast growth factor 4 0.62885
IRF6 interferon regulatory factor 6 0.625711
SOX9 SRY (sex determining region Y)-box 9 0.623359
FGF9 fibroblast growth factor 9 0.615921
FBN1 fibrillin 1 0.609276
ATRN attractin 0.609276
TNNT3 troponin T type 3 (skeletal, fast) 0.594843
GRIP1 glutamate receptor interacting protein 1 0.588612
HOXD3 homeobox D3 0.579272
TWIST1 twist family bHLH transcription factor 1 0.571107
GOSR2 golgi SNAP receptor complex member 2 0.570329
BAG4 BCL2-associated athanogene 4 0.568775
EBP emopamil binding protein (sterol isomerase) 0.566443
TRPV6 transient receptor potential cation channel, subfamily V, member 6 0.562946
PTCH1 patched 1 0.553627
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.535409
SFRP2 secreted frizzled-related protein 2 0.533861
CUL4B cullin 4B 0.526904
SP8 Sp8 transcription factor 0.525746
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2 0.518034
LRP6 low density lipoprotein receptor-related protein 6 0.51534
HMX2 H6 family homeobox 2 0.513802
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5 0.513802
PRAC1 prostate cancer susceptibility candidate 1 0.513802
ABHD5 abhydrolase domain containing 5 0.511496
HMCN1 hemicentin 1 0.50689
FGF6 fibroblast growth factor 6 0.501527
HOXD10 homeobox D10 0.498467
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.496939
SYCN syncollin 0.492359
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.490454
GJC2 gap junction protein, gamma 2, 47kDa 0.485885
ADAM23 ADAM metallopeptidase domain 23 0.481705
RAB23 RAB23, member RAS oncogene family 0.479047
SP6 Sp6 transcription factor 0.474119
STRA6 stimulated by retinoic acid 6 0.463905
CHRD chordin 0.463149
LRP5 low density lipoprotein receptor-related protein 5 0.449194
EVC2 Ellis van Creveld syndrome 2 0.444676
ALDH1A3 aldehyde dehydrogenase 1 family, member A3 0.438658
KARS lysyl-tRNA synthetase 0.409787
TCF12 transcription factor 12 0.404557
GAS1 growth arrest-specific 1 0.401199
CTNND2 catenin (cadherin-associated protein), delta 2 0.399707
DAD1 defender against cell death 1 0.397098
PHF6 PHD finger protein 6 0.38111
AMER1 APC membrane recruitment protein 1 0.37629
FGF19 fibroblast growth factor 19 0.373328
ADAM28 ADAM metallopeptidase domain 28 0.359289
ADD2 adducin 2 (beta) 0.356341
BCOR BCL6 corepressor 0.343473
EN2 engrailed homeobox 2 0.334315
SUOX sulfite oxidase 0.331025
SALL1 spalt-like transcription factor 1 0.3292
SEPN1 selenoprotein N, 1 0.328469
TALDO1 transaldolase 1 0.328105
SMAD5 SMAD family member 5 0.326281
EPHA7 EPH receptor A7 0.325916
SRY sex determining region Y 0.324094
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.319363
DLG3 discs, large homolog 3 (Drosophila) 0.312102
ACVR2A activin A receptor, type IIA 0.311377
CDAN1 codanin 1 0.31029
ANKH ANKH inorganic pyrophosphate transport regulator 0.309566
SUFU suppressor of fused homolog (Drosophila) 0.308118
PROKR2 prokineticin receptor 2 0.300533
SIX2 SIX homeobox 2 0.298731
FGF7 fibroblast growth factor 7 0.297291
THEM4 thioesterase superfamily member 4 0.296211
WNT10B wingless-type MMTV integration site family, member 10B 0.294772
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 0.293334
MYOT myotilin 0.292257
HRAS Harvey rat sarcoma viral oncogene homolog 0.289744
JAG1 jagged 1 0.274021
FOXM1 forkhead box M1 0.270819
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) 0.263368
NOTCH1 notch 1 0.259124
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.257005
CA6 carbonic anhydrase VI 0.255241
MUSK muscle, skeletal, receptor tyrosine kinase 0.253831
MKKS McKusick-Kaufman syndrome 0.253479
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 0.252422
BBS4 Bardet-Biedl syndrome 4 0.25207
TBX3 T-box 3 0.242595
ASPH aspartate beta-hydroxylase 0.241196
COL7A1 collagen, type VII, alpha 1 0.237706
FGF1 fibroblast growth factor 1 (acidic) 0.232489
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle) 0.225917
CPLX3 complexin 3 0.223853
DSC3 desmocollin 3 0.215992
WNT2 wingless-type MMTV integration site family member 2 0.210589
PROK2 prokineticin 2 0.208914
NUMB numb homolog (Drosophila) 0.208245
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.203604
SPAST spastin 0.188632
LARGE like-glycosyltransferase 0.188326
NBN nibrin 0.18621
ATXN1 ataxin 1 0.184424
CHD7 chromodomain helicase DNA binding protein 7 0.180652
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.179802
JAG2 jagged 2 0.179802
HMX1 H6 family homeobox 1 0.177576
EXT2 exostosin glycosyltransferase 2 0.175947
NID1 nidogen 1 0.173832
BMPR1A bone morphogenetic protein receptor, type IA 0.166544
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 0.162908