synovitis Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description A connective tissue disease that results_in inflammation located_in synovial membrane that lines a synovial joint which causes pain and swelling. (Human Disease Ontology, DOID_2703)
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Genes

257 genes co-occuring with the disease synovitis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
CRP C-reactive protein, pentraxin-related 1.64936
TNF tumor necrosis factor 1.55114
IL1B interleukin 1, beta 1.51721
PHB2 prohibitin 2 1.47286
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 1.45353
MMP3 matrix metallopeptidase 3 1.44474
CD68 CD68 molecule 1.42235
COMP cartilage oligomeric matrix protein 1.2765
MMP1 matrix metallopeptidase 1 1.27039
CD4 CD4 molecule 1.15198
MRAP melanocortin 2 receptor accessory protein 1.10552
CD163 CD163 molecule 1.09797
BCKDHA branched chain keto acid dehydrogenase E1, alpha polypeptide 1.08118
IL6 interleukin 6 1.04756
ACAN aggrecan 1.02692
MEFV Mediterranean fever 0.99697
IL1RN interleukin 1 receptor antagonist 0.993174
SAAL1 serum amyloid A-like 1 0.929173
LILRA5 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5 0.893769
ACPP acid phosphatase, prostate 0.862228
ICAM1 intercellular adhesion molecule 1 0.855677
CSF1 colony stimulating factor 1 (macrophage) 0.850354
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.830279
MMP13 matrix metallopeptidase 13 0.829869
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 0.828639
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 0.814693
F8 coagulation factor VIII, procoagulant component 0.806077
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) 0.803616
TAC1 tachykinin, precursor 1 0.802385
CD79A CD79a molecule, immunoglobulin-associated alpha 0.781069
OR2M3 olfactory receptor, family 2, subfamily M, member 3 0.778613
IL17A interleukin 17A 0.774114
IL1A interleukin 1, alpha 0.77207
CSF1R colony stimulating factor 1 receptor 0.76431
IL15 interleukin 15 0.754934
VCAM1 vascular cell adhesion molecule 1 0.74436
MMP9 matrix metallopeptidase 9 0.740705
MOAP1 modulator of apoptosis 1 0.734622
CXCL8 chemokine (C-X-C motif) ligand 8 0.729762
NOTCH1 notch 1 0.722482
TIMP1 TIMP metallopeptidase inhibitor 1 0.722482
ALB albumin 0.718039
UCMA upper zone of growth plate and cartilage matrix associated 0.71078
CCL2 chemokine (C-C motif) ligand 2 0.692697
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.675909
MSMB microseminoprotein, beta- 0.673917
CALCR calcitonin receptor 0.660008
KRT36 keratin 36, type I 0.649718
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5 0.63907
CD38 CD38 molecule 0.635528
MIOS missing oocyte, meiosis regulator, homolog (Drosophila) 0.631598
HMGB1 high mobility group box 1 0.62728
CD44 CD44 molecule (Indian blood group) 0.622183
GPI glucose-6-phosphate isomerase 0.619834
CXCL13 chemokine (C-X-C motif) ligand 13 0.619442
PRTN3 proteinase 3 0.618268
LYZ lysozyme 0.613574
TRBC1 T cell receptor beta constant 1 0.613183
SELE selectin E 0.609276
SLC25A29 solute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29 0.586665
TLR4 toll-like receptor 4 0.582773
TGFB1 transforming growth factor, beta 1 0.577716
IL4 interleukin 4 0.573439
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 0.57305
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3 0.569941
PIH2 pregnancy-induced hypertension syndrome-related protein 0.567997
SIK1 salt-inducible kinase 1 0.566054
MMP2 matrix metallopeptidase 2 0.555956
CTSK cathepsin K 0.555956
C3 complement component 3 0.551686
S100A8 S100 calcium binding protein A8 0.537344
LPIN2 lipin 2 0.537344
IL18 interleukin 18 0.529994
ANKLE2 ankyrin repeat and LEM domain containing 2 0.523045
CMC1 C-x(9)-C motif containing 1 0.517649
B2M beta-2-microglobulin 0.502292
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 0.494648
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 0.491597
HLA-C major histocompatibility complex, class I, C 0.485885
LARS leucyl-tRNA synthetase 0.477151
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 0.472225
PGP phosphoglycolate phosphatase 0.471846
ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 0.471468
GUSB glucuronidase, beta 0.471089
VWF von Willebrand factor 0.467684
SRXN1 sulfiredoxin 1 0.462394
GALNT15 polypeptide N-acetylgalactosaminyltransferase 15 0.458996
HBA2 hemoglobin, alpha 2 0.456732
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.456355
NPS neuropeptide S 0.452585
LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2 0.450324
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 0.449947
KNG1 kininogen 1 0.44129
CCL20 chemokine (C-C motif) ligand 20 0.440538
FN1 fibronectin 1 0.440162
MARCH8 membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase 0.434899
TIMP2 TIMP metallopeptidase inhibitor 2 0.432646
HLA-DRB4 major histocompatibility complex, class II, DR beta 4 0.431519
SYK spleen tyrosine kinase 0.430768
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.430017
SETD1A SET domain containing 1A 0.42664
C5AR1 complement component 5a receptor 1 0.42664
IL22RA1 interleukin 22 receptor, alpha 1 0.425139
GLS glutaminase 0.41465
LAPTM5 lysosomal protein transmembrane 5 0.41465
CCL21 chemokine (C-C motif) ligand 21 0.410909
IL34 interleukin 34 0.407172
MPO myeloperoxidase 0.406425
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.403811
SPP1 secreted phosphoprotein 1 0.403438
ALG1 ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase 0.400826
TSPO translocator protein (18kDa) 0.394863
CTSD cathepsin D 0.392257
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2 0.383708
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 0.379997
TNC tenascin C 0.379997
MMP8 matrix metallopeptidase 8 0.378885
SH3BP2 SH3-domain binding protein 2 0.378143
S100A12 S100 calcium binding protein A12 0.37629
IRAK3 interleukin-1 receptor-associated kinase 3 0.37629
CXCR2 chemokine (C-X-C motif) receptor 2 0.375179
CD80 CD80 molecule 0.374068
PLA2G1B phospholipase A2, group IB (pancreas) 0.370368
WISP3 WNT1 inducible signaling pathway protein 3 0.369628
CXCL12 chemokine (C-X-C motif) ligand 12 0.367779
CD34 CD34 molecule 0.36704
PRG4 proteoglycan 4 0.360026
PADI4 peptidyl arginine deiminase, type IV 0.353763
ADAMTS8 ADAM metallopeptidase with thrombospondin type 1 motif, 8 0.353763
MATN1 matrilin 1, cartilage matrix protein 0.353027
HBA1 hemoglobin, alpha 1 0.352291
LAMP3 lysosomal-associated membrane protein 3 0.350084
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.346777
S100A9 S100 calcium binding protein A9 0.340539
PDE1B phosphodiesterase 1B, calmodulin-dependent 0.339073
HLA-B major histocompatibility complex, class I, B 0.338341
HLA-DRB5 major histocompatibility complex, class II, DR beta 5 0.337975
IL6R interleukin 6 receptor 0.336876
ADAMTS17 ADAM metallopeptidase with thrombospondin type 1 motif, 17 0.336876
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) 0.328834
CTSL cathepsin L 0.324823
TMEM173 transmembrane protein 173 0.322637
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.318999
FOLR2 folate receptor 2 (fetal) 0.316819
PLAU plasminogen activator, urokinase 0.316819
SPHK2 sphingosine kinase 2 0.316092
OSM oncostatin M 0.314278
MAP2K7 mitogen-activated protein kinase kinase 7 0.305226
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase 0.305226
IL2 interleukin 2 0.304503
PID1 phosphotyrosine interaction domain containing 1 0.301254
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase 0.296931
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b 0.293334
COL6A3 collagen, type VI, alpha 3 0.289744
GADD45B growth arrest and DNA-damage-inducible, beta 0.286519
SLC38A1 solute carrier family 38, member 1 0.285802
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.28294
FLT1 fms-related tyrosine kinase 1 0.282225
F2RL1 coagulation factor II (thrombin) receptor-like 1 0.278654
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 0.27794
AMT aminomethyltransferase 0.276514
GLS2 glutaminase 2 (liver, mitochondrial) 0.273308
PANX2 pannexin 2 0.270464
IL2RA interleukin 2 receptor, alpha 0.267267
VEGFA vascular endothelial growth factor A 0.266558
FGF2 fibroblast growth factor 2 (basic) 0.26514
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.26514
IGHV5-51 immunoglobulin heavy variable 5-51 0.263722
CD69 CD69 molecule 0.263368
PTDSS1 phosphatidylserine synthase 1 0.261952
CD58 CD58 molecule 0.259477
ASPN asporin 0.258064
SRMS src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites 0.251366
SOS1 son of sevenless homolog 1 (Drosophila) 0.246098
FLG filaggrin 0.245747
SLC52A3 solute carrier family 52 (riboflavin transporter), member 3 0.245747
ENPP3 ectonucleotide pyrophosphatase/phosphodiesterase 3 0.244696
FTH1 ferritin, heavy polypeptide 1 0.240497
JUN jun proto-oncogene 0.240148
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 0.237009
PDGFB platelet-derived growth factor beta polypeptide 0.235616
PTGES prostaglandin E synthase 0.235268
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 0.23492
CXCR1 chemokine (C-X-C motif) receptor 1 0.23353
CALCA calcitonin-related polypeptide alpha 0.233183
PRELP proline/arginine-rich end leucine-rich repeat protein 0.231448
IFI44L interferon-induced protein 44-like 0.227297
PGF placental growth factor 0.225573
CUL5 cullin 5 0.223853
MARCO macrophage receptor with collagenous structure 0.221793
TACR1 tachykinin receptor 1 0.220424
TRIM21 tripartite motif containing 21 0.218715
FBXO2 F-box protein 2 0.215992
TLR2 toll-like receptor 2 0.215992
MMP17 matrix metallopeptidase 17 (membrane-inserted) 0.214975
ITGAD integrin, alpha D 0.212271
HSPG2 heparan sulfate proteoglycan 2 0.211597
NGF nerve growth factor (beta polypeptide) 0.211597
PNN pinin, desmosome associated protein 0.209583
TYMP thymidine phosphorylase 0.209248
IL23A interleukin 23, alpha subunit p19 0.208914
SNRNP40 small nuclear ribonucleoprotein 40kDa (U5) 0.208245
KLRB1 killer cell lectin-like receptor subfamily B, member 1 0.207578
FTL ferritin, light polypeptide 0.205916
PCNA proliferating cell nuclear antigen 0.205254
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) 0.204263
RARRES2 retinoic acid receptor responder (tazarotene induced) 2 0.201635
STAT1 signal transducer and activator of transcription 1, 91kDa 0.200331
OSCAR osteoclast associated, immunoglobulin-like receptor 0.200331
MAPK8 mitogen-activated protein kinase 8 0.200331
SEBOX SEBOX homeobox 0.199681
CTLA4 cytotoxic T-lymphocyte-associated protein 4 0.199681
TANK TRAF family member-associated NFKB activator 0.196459
ACOT13 acyl-CoA thioesterase 13 0.191097
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 0.189859
SELL selectin L 0.188938
CD40LG CD40 ligand 0.188938
IL17RA interleukin 17 receptor A 0.188326
FZD5 frizzled class receptor 5 0.188022
IFI44 interferon-induced protein 44 0.187719
KLRG1 killer cell lectin-like receptor subfamily G, member 1 0.18651
THY1 Thy-1 cell surface antigen 0.185612
SAA4 serum amyloid A4, constitutive 0.184424
CCL8 chemokine (C-C motif) ligand 8 0.182375
XCR1 chemokine (C motif) receptor 1 0.182086
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2 0.180367
MMP15 matrix metallopeptidase 15 (membrane-inserted) 0.179239
CD19 CD19 molecule 0.177576
HAGH hydroxyacylglutathione hydrolase 0.177301
FRZB frizzled-related protein 0.173832
CR1 complement component (3b/4b) receptor 1 (Knops blood group) 0.173571
CD47 CD47 molecule 0.170544
VIL1 villin 1 0.167224
SOD2 superoxide dismutase 2, mitochondrial 0.166319
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.166095
WRNIP1 Werner helicase interacting protein 1 0.165435
CD53 CD53 molecule 0.163523
ALOX5AP arachidonate 5-lipoxygenase-activating protein 0.161043
PLA2G10 phospholipase A2, group X 0.160948
MAPK3 mitogen-activated protein kinase 3 0.160203
ANGPTL2 angiopoietin-like 2 0.158951
MKI67 marker of proliferation Ki-67 0.155595
SKP1 S-phase kinase-associated protein 1 0.145354
HSPA8 heat shock 70kDa protein 8 0.144498
TP53 tumor protein p53 0.144435
CALD1 caldesmon 1 0.144226
MITF microphthalmia-associated transcription factor 0.143887
TRAC T cell receptor alpha constant 0.143498
PMEL premelanosome protein 0.143384
MYOG myogenin (myogenic factor 4) 0.143284
NF1 neurofibromin 1 0.143179
KRT18 keratin 18, type I 0.142934
MYOD1 myogenic differentiation 1 0.142319
KRT8 keratin 8, type II 0.141924
PTPRC protein tyrosine phosphatase, receptor type, C 0.141576
CALB2 calbindin 2 0.141296
PRRC2A proline-rich coiled-coil 2A 0.141125