syphilis Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description A primary bacterial infectious disease that is a sexually transmitted systemic disease, has_material_basis_in Treponema pallidum subsp pallidum, which is transmitted_by sexual contact, transmitted_by blood product transfusion, transmitted_by congenital method from mother to fetus or transmitted_by contact with infectious lesions. If left untreated, produces chancres, rashes, and systemic lesions in a clinical course with three stages continued over many years. (Human Disease Ontology, DOID_4166)
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Genes

178 genes co-occuring with the disease syphilis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
EXTL3 exostosin-like glycosyltransferase 3 3.37193
TPR translocated promoter region, nuclear basket protein 2.09149
CD4 CD4 molecule 1.77857
APOH apolipoprotein H (beta-2-glycoprotein I) 1.74233
RNF112 ring finger protein 112 1.61665
CD79A CD79a molecule, immunoglobulin-associated alpha 1.19661
TES testin LIM domain protein 1.15965
PART1 prostate androgen-regulated transcript 1 (non-protein coding) 1.1051
TRO trophinin 1.08999
FLYWCH1 FLYWCH-type zinc finger 1 1.06018
F3 coagulation factor III (thromboplastin, tissue factor) 0.838066
LIAS lipoic acid synthetase 0.817976
PRSS21 protease, serine, 21 (testisin) 0.805667
FEZF1 FEZ family zinc finger 1 0.778613
WDFY2 WD repeat and FYVE domain containing 2 0.772479
FEZF2 FEZ family zinc finger 2 0.766759
PARP15 poly (ADP-ribose) polymerase family, member 15 0.756564
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase) 0.756156
INVS inversin 0.735838
ALB albumin 0.735027
F2 coagulation factor II (thrombin) 0.677504
FARSA phenylalanyl-tRNA synthetase, alpha subunit 0.668742
ALPPL2 alkaline phosphatase, placental-like 2 0.6608
ALPP alkaline phosphatase, placental 0.660404
ETV7 ets variant 7 0.660008
ALPL alkaline phosphatase, liver/bone/kidney 0.660008
APOLD1 apolipoprotein L domain containing 1 0.625319
GET4 golgi to ER traffic protein 4 homolog (S. cerevisiae) 0.621792
ATAD2 ATPase family, AAA domain containing 2 0.61866
HBE1 hemoglobin, epsilon 1 0.598351
FN1 fibronectin 1 0.594843
CPZ carboxypeptidase Z 0.592116
IARS isoleucyl-tRNA synthetase 0.591337
KIR3DL3 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3 0.555568
KIR2DS4 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4 0.546644
OR4F29 olfactory receptor, family 4, subfamily F, member 29 0.545481
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) 0.545481
CRP C-reactive protein, pentraxin-related 0.541605
BLOC1S6 biogenesis of lysosomal organelles complex-1, subunit 6, pallidin 0.538118
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.534248
FLNA filamin A, alpha 0.522273
LYZ lysozyme 0.520731
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase 0.513802
TTC39A tetratricopeptide repeat domain 39A 0.501144
IGLV3-9 immunoglobulin lambda variable 3-9 (gene/pseudogene) 0.493122
HIAT1 hippocampus abundant transcript 1 0.490072
FCMR Fc fragment of IgM receptor 0.466172
SRY sex determining region Y 0.449947
MID2 midline 2 0.443923
RHOBTB2 Rho-related BTB domain containing 2 0.440162
TUBE1 tubulin, epsilon 1 0.431519
WNT10A wingless-type MMTV integration site family, member 10A 0.42139
SARDH sarcosine dehydrogenase 0.417644
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B 0.416896
PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta 0.408666
STPG1 sperm-tail PG-rich repeat containing 1 0.404931
RHD Rh blood group, D antigen 0.397098
CEP104 centrosomal protein 104kDa 0.386308
ARR3 arrestin 3, retinal (X-arrestin) 0.384079
DNAJC16 DnaJ (Hsp40) homolog, subfamily C, member 16 0.378514
PRRC2A proline-rich coiled-coil 2A 0.371107
PER1 period circadian clock 1 0.365932
WARS tryptophanyl-tRNA synthetase 0.36187
GOT1 glutamic-oxaloacetic transaminase 1, soluble 0.360026
MMP23B matrix metallopeptidase 23B 0.353027
ZBTB32 zinc finger and BTB domain containing 32 0.352659
WAPAL wings apart-like homolog (Drosophila) 0.351555
GRASP GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein 0.349717
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.346777
IRF6 interferon regulatory factor 6 0.342739
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila) 0.340173
POMC proopiomelanocortin 0.33651
TAS1R1 taste receptor, type 1, member 1 0.335046
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 0.332121
RPL22 ribosomal protein L22 0.32373
RHCE Rh blood group, CcEe antigens 0.323365
CD80 CD80 molecule 0.321181
EPRS glutamyl-prolyl-tRNA synthetase 0.321181
CP ceruloplasmin (ferroxidase) 0.32009
SPTLC1 serine palmitoyltransferase, long chain base subunit 1 0.318635
TTC34 tetratricopeptide repeat domain 34 0.317182
GGT1 gamma-glutamyltransferase 1 0.313189
PAPD7 PAP associated domain containing 7 0.311377
SEPT1 septin 1 0.304864
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 0.304864
HP haptoglobin 0.303781
PNKD paroxysmal nonkinesigenic dyskinesia 0.297651
IL31RA interleukin 31 receptor A 0.297651
HPR haptoglobin-related protein 0.297651
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 0.297651
TCEA1 transcription elongation factor A (SII), 1 0.290462
CD83 CD83 molecule 0.280796
CFD complement factor D (adipsin) 0.280082
AMD1 adenosylmethionine decarboxylase 1 0.278654
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 0.275445
MOGS mannosyl-oligosaccharide glucosidase 0.266913
CD68 CD68 molecule 0.25983
KAT8 K(lysine) acetyltransferase 8 0.258417
CCNE1 cyclin E1 0.255594
PKD2L1 polycystic kidney disease 2-like 1 0.254536
OR10T2 olfactory receptor, family 10, subfamily T, member 2 0.252774
LSR lipolysis stimulated lipoprotein receptor 0.250311
AURKAIP1 aurora kinase A interacting protein 1 0.249608
RAET1E retinoic acid early transcript 1E 0.248203
TGM1 transglutaminase 1 0.247852
STIL SCL/TAL1 interrupting locus 0.24715
POMP proteasome maturation protein 0.241196
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) 0.22454
USP9X ubiquitin specific peptidase 9, X-linked 0.222822
DCPS decapping enzyme, scavenger 0.222479
CUTA cutA divalent cation tolerance homolog (E. coli) 0.213959
F8 coagulation factor VIII, procoagulant component 0.211597
CREG1 cellular repressor of E1A-stimulated genes 1 0.210925
MYBPC1 myosin binding protein C, slow type 0.208914
CXCL13 chemokine (C-X-C motif) ligand 13 0.204263
CFB complement factor B 0.203604
TPRG1L tumor protein p63 regulated 1-like 0.203275
DYNLRB1 dynein, light chain, roadblock-type 1 0.201962
CAT catalase 0.201962
TLR2 toll-like receptor 2 0.196139
SUOX sulfite oxidase 0.196139
ANXA5 annexin A5 0.194548
TXN thioredoxin 0.191719
BPGM 2,3-bisphosphoglycerate mutase 0.189244
PGAM2 phosphoglycerate mutase 2 (muscle) 0.187113
KIR2DL2 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2 0.175947
GGT2 gamma-glutamyltransferase 2 0.175947
FLAD1 flavin adenine dinucleotide synthetase 1 0.175679
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 0.174093
STYK1 serine/threonine/tyrosine kinase 1 0.174093
KEL Kell blood group, metallo-endopeptidase 0.173057
HES2 hes family bHLH transcription factor 2 0.172799
ARNT aryl hydrocarbon receptor nuclear translocator 0.168617
IGLL5 immunoglobulin lambda-like polypeptide 5 0.166319
OSTC oligosaccharyltransferase complex subunit (non-catalytic) 0.166095
MRAP melanocortin 2 receptor accessory protein 0.166095
LCK LCK proto-oncogene, Src family tyrosine kinase 0.165655
KIF5B kinesin family member 5B 0.165001
C4A complement component 4A (Rodgers blood group) 0.164149
UBIAD1 UbiA prenyltransferase domain containing 1 0.162707
ACE angiotensin I converting enzyme 0.161523
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 0.159658
SOX11 SRY (sex determining region Y)-box 11 0.158266
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5 0.144015
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 0.143723
TCHH trichohyalin 0.143017
MBP myelin basic protein 0.142859
COL6A1 collagen, type VI, alpha 1 0.141575
IL17A interleukin 17A 0.141356
MAPK1 mitogen-activated protein kinase 1 0.141157
TRIM37 tripartite motif containing 37 0.140456
FXN frataxin 0.140275
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 0.132273
NELFCD negative elongation factor complex member C/D 0.1249
CD22 CD22 molecule 0.122643
FES FES proto-oncogene, tyrosine kinase 0.119725
GALK1 galactokinase 1 0.117982
IL4 interleukin 4 0.115844
FKBP4 FK506 binding protein 4, 59kDa 0.115115
NCR3 natural cytotoxicity triggering receptor 3 0.113889
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16 0.112584
ASPN asporin 0.110263
RRM1 ribonucleotide reductase M1 0.103578
FTH1 ferritin, heavy polypeptide 1 0.101405
FTL ferritin, light polypeptide 0.101405
ICAM3 intercellular adhesion molecule 3 0.100295
PRF1 perforin 1 (pore forming protein) 0.097866
CD209 CD209 molecule 0.096773
LAP3 leucine aminopeptidase 3 0.089892
OAT ornithine aminotransferase 0.087932
MKI67 marker of proliferation Ki-67 0.086622
KNG1 kininogen 1 0.085096
NCAM1 neural cell adhesion molecule 1 0.081846
CXCL10 chemokine (C-X-C motif) ligand 10 0.078829
CD27 CD27 molecule 0.078338
G6PD glucose-6-phosphate dehydrogenase 0.077
B2M beta-2-microglobulin 0.076894
IL10 interleukin 10 0.076858